Comparison of the acute effects of &lt;i&gt;Tulbaghia violacea&lt;/i&gt; William Henry Harvey (Alliaceae) on blood pressure and heart rate of ageing male normotensive Wistar kyoto rats and adult male spontaneously hypertensive rats

Raji, Ismaila; Obikeze, Kenechukwu; Mugabo, Pierre

doi:10.4314/tjpr.v15i11.18

Cited by 4 publications

(2 citation statements)

References 15 publications

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“…The antioxidant, cytotoxic, antiparasitic, antimicrobial, antibacterial, anthelminthic, antiamoebic, antidiabetic, hypolipidemic, anti-HIV, antithrombotic, androgenic, anticancer, and antihypertensive properties [18,29,34,103] of the plant have been reported, as has the safety profile. In fact, in a study by Raji et al [104,105], a methanolic leaf extract of the plant at various concentrations (5,10,20,40,60,80, 160 mg/kg b. w.) lowered the BP (systolic, diastolic), mean ar-terial pressure and heart rate of ageing male normotensive and adult male spontaneously hypertensive rats in a dose-dependent manner, suggesting its antihypertensive effects. Similarly, Ramesar and others [18] reported the inhibition of ACE using aqueous (68 %) and methanolic (71 %) extracts of the plant in an in vitro study.…”

Section: Tulbaghia Violacea Harvmentioning

confidence: 96%

A Review of Plants Used in South African Traditional Medicine for the Management and Treatment of Hypertension

Balogun

Ashafa

2018

Planta Med

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South Africa contains 9% of the worldʼs higher plants, and despite its rich biodiversity, it has one of the highest prevalence of hypertension in Africa. This review provides information on medicinal plants embraced in South Africa for hypertension management, with the aim of reporting pharmacological information on the indigenous use of these plants as antihypertensives. This review not only focuses on the activity of antihypertensive medicinal plants but also reports some of its phytochemical constituents and other ethnopharmacological and therapeutic properties. Information obtained from scientific and or unpublished databases such as Science Direct, PubMed, SciFinder, JSTOR, Google Scholar, Web of Science, and various books revealed 117 documented antihypertensive plant species from 50 families. Interestingly, Asteraceae topped the list with 16 species, followed by Fabaceae with 8 species; however, only 25% of all plant species have demonstrated antihypertensive effects originating from both in vitro and in vivo studies, lending credence to their folkloric use. Only 11 plant species reportedly possess antihypertensive properties in animal models, with very few species subjected to analytical processes to reveal the identity of their bioactive antihypertensive compounds. In this review, we hope to encourage researchers and global research institutions (universities, agricultural research councils, and medical research councils), particularly those showing an interest in natural products, for the need for concerted efforts to undertake more studies aimed at revealing the untapped potential of these plants. These studies are very important for the development of new pharmaceuticals of natural origin useful for the management of hypertension.

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Section: Tulbaghia Violacea Harvmentioning

confidence: 96%

A Review of Plants Used in South African Traditional Medicine for the Management and Treatment of Hypertension

Balogun

Ashafa

2018

Planta Med

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“…These data were corroborated in another study in which T. violacea noticeably reduced blood glucose and serum lipid (triglyceride (TG), total cholesterol (TC), and very low-density lipoprotein (VLDL)) levels while raising plasma insulin in a streptozotocin-induced diabetic rat model [ 97 ]. In an assessment for negating cardiovascular associated conditions, T. violacea in in vivo models markedly reduced systolic blood pressure (BP), diastolic BP, mean arterial pressure (MAP) and the heart rate in both age-induced and spontaneous hypertensive rats [ 98 ]. Furthermore, dosing rats with extracts of T. violacea led to improved kidney function [ 99 ].…”

Section: The Genus Tulbaghiamentioning

confidence: 99%

The Phytochemistry and Pharmacology of Tulbaghia, Allium, Crinum and Cyrtanthus: ‘Talented’ Taxa from the Amaryllidaceae

et al. 2022

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Amaryllidaceae is a significant source of bioactive phytochemicals with a strong propensity to develop new drugs. The genera Allium, Tulbaghia, Cyrtanthus and Crinum biosynthesize novel alkaloids and other phytochemicals with traditional and pharmacological uses. Amaryllidaceae biomolecules exhibit multiple pharmacological activities such as antioxidant, antimicrobial, and immunomodulatory effects. Traditionally, natural products from Amaryllidaceae are utilized to treat non-communicable and infectious human diseases. Galanthamine, a drug from this family, is clinically relevant in treating the neurocognitive disorder, Alzheimer’s disease, which underscores the importance of the Amaryllidaceae alkaloids. Although Amaryllidaceae provide a plethora of biologically active compounds, there is tardiness in their development into clinically pliable medicines. Other genera, including Cyrtanthus and Tulbaghia, have received little attention as potential sources of promising drug candidates. Given the reciprocal relationship of the increasing burden of human diseases and limited availability of medicinal therapies, more rapid drug discovery and development are desirable. To expedite clinically relevant drug development, we present here evidence on bioactive compounds from the genera Allium, Tulgbaghia, Cyrtanthus and Crinum and describe their traditional and pharmacological applications.

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Protective role of wild garlic on isoproterenol-induced myocardial necrosis in wistar rats

Murugesan

Arunagiri

Saravanakumar

et al. 2019

Journal of Ethnopharmacology

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Comparison of the acute effects of <i>Tulbaghia violacea</i> William Henry Harvey (Alliaceae) on blood pressure and heart rate of ageing male normotensive Wistar kyoto rats and adult male spontaneously hypertensive rats

Cited by 4 publications

References 15 publications

A Review of Plants Used in South African Traditional Medicine for the Management and Treatment of Hypertension

A Review of Plants Used in South African Traditional Medicine for the Management and Treatment of Hypertension

The Phytochemistry and Pharmacology of Tulbaghia, Allium, Crinum and Cyrtanthus: ‘Talented’ Taxa from the Amaryllidaceae

Protective role of wild garlic on isoproterenol-induced myocardial necrosis in wistar rats

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