2014
DOI: 10.3233/bme-130911
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Abstract: Early detection of skull base invasion in nasopharyngeal carcinoma (NPC) is crucial for correct staging, assessing treatment response and contouring the tumor target in radiotherapy planning, as well as improving the patient's prognosis. To compare the diagnostic efficacy of single photon emission computed tomography/computed tomography (SPECT/CT) imaging, magnetic resonance imaging (MRI) and computed tomography (CT) for the detection of skull base invasion in NPC. Sixty untreated patients with histologically … Show more

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Cited by 17 publications
(12 citation statements)
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“…Chung et al [32] also found approximately 96.1 % of patients with pterygopalatine fossa involvement accompanied with intracranial extension. Moreover, it has been indicated that invasive rates of the orbit, laryngopharynx, and cervical vertebra were very low [33], and involvement of the soft palatine has been seldom reported. According to these studies, we remove anterior cervical vertebrae soft tissue, soft palatine, pterygopalatine fossa, and orbit in the Chinese 2008 staging system.…”
Section: Any Cranial Nerve Involvement Was Reclassified As T4mentioning
confidence: 99%
“…Chung et al [32] also found approximately 96.1 % of patients with pterygopalatine fossa involvement accompanied with intracranial extension. Moreover, it has been indicated that invasive rates of the orbit, laryngopharynx, and cervical vertebra were very low [33], and involvement of the soft palatine has been seldom reported. According to these studies, we remove anterior cervical vertebrae soft tissue, soft palatine, pterygopalatine fossa, and orbit in the Chinese 2008 staging system.…”
Section: Any Cranial Nerve Involvement Was Reclassified As T4mentioning
confidence: 99%
“…Therefore, the outcome of the therapeutic interventions is not ideal, and the 5-year survival rate is still about 50 % in spite of great innovations in radiation and chemotherapy treatments [ 6 , 7 ]. At present, NPC is mainly diagnosed by imaging exams, but the high cost of the tests, the inaccuracy of evaluation of treatment efficacy and the poor sensitivity in diagnosing metastasis have limited their clinical use [ 8 ]. High expression of matrix metalloproteinase 1 (MMP-1) and lower expression of tissue factor pathway inhibitory factor 2 (TFPI-2) are closely related to neck lymph node metastasis of NPC.…”
Section: Introductionmentioning
confidence: 99%
“…MR imaging is superior to CT in the detection of skull base involvement. [8][9][10][11] Several studies have used MR imaging to examine abnormalities of the skull base in patients with NPC. [17][18][19][20][21]24 Lu et al 20 reported worse prognosis when Ն2 sites of skull base invasion were found on MR imaging.…”
Section: Discussionmentioning
confidence: 99%
“…Findings of skull base invasion were considered positive in cases in which the skull base had signals similar to those of the adjacent tumor on all pre-and postcontrast T1-weighted images in the cortical bone and bone marrow space on the MR image (low signal intensity on a T1-weighted image and contrast enhancement on the postcontrast T1-weighted image with fat suppression). 8,9,[17][18][19][20][21] We performed evaluations mainly on the basis of the precontrast 3D T1-weighted Dixon in-phase image and the postcontrast 3D T1-weighted Dixon water image. Other sequences were also used for identifying tumor location.…”
Section: Mr Imaging and Ct Diagnostic Criteria For Skull Base Invasionmentioning
confidence: 99%
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