Comparison of slope-intercept with single plasma sample methods in estimating glomerular filtration rate using radionuclides

Osman, Abdelbagi; Elmadani, Ahmed E.

doi:10.4103/1319-2442.128521

Cited by 2 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results obtained in our study correlate with the findings of other authors. Osman and Elmadani found a correlation coefficient r = 0.96 between Fleming's single sample method and the slope--intercept method as the reference one [15]. These authors concluded Gates -Gates' protocol; SD -standard deviation; SPSM -single plasma sample method that the SPSM significantly correlated with the reference method, especially in the interval of GFR values from 40 to 90 mL/min/1.73 m 2 and reported slight underestimation for both, very low and very high values of GFR.…”

Section: Originalmentioning

confidence: 99%

Comparative analysis of different nuclear medicine techniques in evaluation of renal function

et al. 2023

View full text Add to dashboard Cite

Introduction: Nuclear medicine (NM) methods play an important role in the evaluation of renal function in a wide range of clinical indications. The aim of our study was to evaluate the correlation between measured GFR (mGFR) obtained by the three-plasma sample slope-intercept NM method (TPSM) -reference method vs. estimated GFR (eGFR) using Fleming's single plasma sample method (SPSM) at 120 min, 180 min, and 240 min and correlation of reference method with eGFR with camera-based Gates' protocol. Material and methods:A total of 82 subjects (33 male/49 female) with a mean age of 54.87 ± 15.65 years were included and mGFR value was obtained by the three-plasma sample slope-intercept NM method and eGFR was obtained with Fleming's single sample method. eGFR was also quantified with the camera-based Gates' protocol after i.v. application of [ 99m Tc]Tc-DTPA. Results:Our study revealed a very strong positive significant correlation between all three SPSMs with the TPSM as the reference method. Between the Gates' method and the TPSM in the group of patients with mGFR ≥ 61-84 mL/min/1.73 m 2 and mGFR ≥ 84 mL/min/1.73 m 2 , a moderate positive statistically significant correlation was obtained. Conclusions:The SPSM method shows a very strong correlation with the reference and low bias in all three groups of patients and can be routinely used for GFR estimation.

show abstract

Section: Originalmentioning

confidence: 99%

Comparative analysis of different nuclear medicine techniques in evaluation of renal function

et al. 2023

View full text Add to dashboard Cite

show abstract

Methods and reporting of kidney function: a systematic review of studies from sub-Saharan Africa

Fabian

George

Etheredge

et al. 2019

Clinical Kidney Journal

View full text Add to dashboard Cite

Globally, chronic kidney disease (CKD) is an emerging public health challenge but accurate data on its true prevalence are scarce, particularly in poorly resourced regions such as sub-Saharan Africa (SSA). Limited funding for population-based studies, poor laboratory infrastructure and the absence of a validated estimating equation for kidney function in Africans are contributing factors. Consequently, most available studies used to estimate population prevalence are hospital-based, with small samples of participants who are at high risk for kidney disease. While serum creatinine is most commonly used to estimate glomerular filtration, there is considerable potential bias in the measurement of creatinine that might lead to inaccurate estimates of kidney disease at individual and population level. To address this, the Laboratory Working Group of the National Kidney Disease Education Program published recommendations in 2006 to standardize the laboratory measurement of creatinine. The primary objective of this review was to appraise implementation of these recommendations in studies conducted in SSA after 2006. Secondary objectives were to assess bias relating to choice of estimating equations for assessing glomerular function in Africans and to evaluate use of recommended diagnostic criteria for CKD. This study was registered with Prospero (CRD42017068151), and using PubMed, African Journals Online and Web of Science, 5845 abstracts were reviewed and 252 full-text articles included for narrative analysis. Overall, two-thirds of studies did not report laboratory methods for creatinine measurement and just over 80% did not report whether their creatinine measurement was isotope dilution mass spectroscopy (IDMS) traceable. For those reporting a method, Jaffe was the most common (93%). The four-variable Modification of Diet in Renal Disease (4-v MDRD) equation was most frequently used (42%), followed by the CKD Epidemiology Collaboration (CKD-EPI) equation for creatinine (26%). For the 4-v MDRD equation and CKD-EPI equations, respectively, one-third to one half of studies clarified use of the coefficient for African-American (AA) ethnicity. When reporting CKD prevalence, <15% of studies fulfilled Kidney Disease: Improving Global Outcomes criteria and even fewer used a population-based sample. Six studies compared performance of estimating equations to measured glomerular filtration rate (GFR) demonstrating that coefficients for AA ethnicity used in the 4-v MDRD and the CKD-EPI equations overestimated GFR in Africans. To improve on reporting in future studies, we propose an ‘easy to use’ checklist that will standardize reporting of kidney function and improve the quality of studies in the region. This research contributes some understanding of the factors requiring attention to ensure accurate assessment of the burden of kidney disease in SSA. Many of these factors are difficult to address and extend beyond individual researchers to health systems and governmental policy, but understanding the burden of kidney disease is a critical first step to informing an integrated public health response that would provide appropriate screening, prevention and management of kidney disease in countries from SSA. This is particularly relevant as CKD is a common pathway in both infectious and non-communicable diseases, and multimorbidity is now commonplace, and even more so when those living with severe kidney disease have limited or no access to renal replacement therapy.

show abstract

Comparison of slope-intercept with single plasma sample methods in estimating glomerular filtration rate using radionuclides

Cited by 2 publications

References 0 publications

Comparative analysis of different nuclear medicine techniques in evaluation of renal function

Comparative analysis of different nuclear medicine techniques in evaluation of renal function

Methods and reporting of kidney function: a systematic review of studies from sub-Saharan Africa

Contact Info

Product

Resources

About