2015
DOI: 10.1007/s10522-015-9560-5
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Abstract: MicroRNAs are non-coding RNAs with roles in many cellular processes. Tissue-specific miRNA profiles associated with senescence have been described for several cell and tissue types. We aimed to characterise miRNAs involved in core, rather than tissue-specific, senescence pathways by assessment of common miRNA expression differences in two different cell types, with follow-up of predicted targets in human peripheral blood. MicroRNAs were profiled in early and late passage primary lung and skin fibrob-lasts to i… Show more

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Cited by 19 publications
(10 citation statements)
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“…4C and 6B ). Lastly, consistent with our findings, up to fourfold decreased miR-15b levels were observed in various models of organismal aging as well as replicative cellular senescence [ 48 , 49 , 55 , 56 ], the latter being in accordance with an increased SIRT4 expression in human fibroblasts undergoing replicative senescence (Fig. 1A ).…”
Section: Resultssupporting
confidence: 91%
“…4C and 6B ). Lastly, consistent with our findings, up to fourfold decreased miR-15b levels were observed in various models of organismal aging as well as replicative cellular senescence [ 48 , 49 , 55 , 56 ], the latter being in accordance with an increased SIRT4 expression in human fibroblasts undergoing replicative senescence (Fig. 1A ).…”
Section: Resultssupporting
confidence: 91%
“…Furthermore, a cornerstone of thymus adipose involution: epithelial-to-mesenchymal transition (EMT), operates via miR-105-5p, miR-200a-3p, miR-597-5p, miR-888, and miR-99b, all demonstrating changes in copy number in steroid-induced TECs (35, 36, 50, 63, 65, 69, 70). Taking a final expansion of interest, from a senescent perspective miR-125a-3p, miR-125a-5p, miR-15b-5p, miR-181a-5p, miR-323-3p, and miR-331-3p affect cellular / tissue level senescence with focus on the thymus and also show significant changes (36, 39, 40, 45, 47, 5658). In summary, steroid-treatment in TECs affects the same miRNA species that were reported in connection with senescence-related thymus adipose involution that apparently yields beige adipose tissue.…”
Section: Discussionmentioning
confidence: 99%
“…Other systems thought to be central to ageing are oxidative stress, inflammatory and immune response, and endothelial barrier dysfunction. 28 Nevertheless, this is an area of considerable therapeutic interest in neurodegenerative diseases, particularly since the announcement of preliminary results from a phase II trial of an antisense oligonucleotide administered intrathecally that showed reduced huntingtin protein in Huntington disease. 25 There is less evidence for histone-specific changes with ageing.…”
Section: Empirical Evidence For Epigenetics and Ageingmentioning
confidence: 99%
“…27 However, relatively few microRNAs are likely to be involved across different tissue types related to coreageing mechanisms, as opposed to tissue-specific types. 28 Nevertheless, this is an area of considerable therapeutic interest in neurodegenerative diseases, particularly since the announcement of preliminary results from a phase II trial of an antisense oligonucleotide administered intrathecally that showed reduced huntingtin protein in Huntington disease. This indicates that therapeutic manipulation at this level of the epigenome may well be more feasible than seeking to reverse site-specific DNA methylation.…”
Section: Empirical Evidence For Epigenetics and Ageingmentioning
confidence: 99%