“…Furthermore, a cornerstone of thymus adipose involution: epithelial-to-mesenchymal transition (EMT), operates via miR-105-5p, miR-200a-3p, miR-597-5p, miR-888, and miR-99b, all demonstrating changes in copy number in steroid-induced TECs (35, 36, 50, 63, 65, 69, 70). Taking a final expansion of interest, from a senescent perspective miR-125a-3p, miR-125a-5p, miR-15b-5p, miR-181a-5p, miR-323-3p, and miR-331-3p affect cellular / tissue level senescence with focus on the thymus and also show significant changes (36, 39, 40, 45, 47, 56–58). In summary, steroid-treatment in TECs affects the same miRNA species that were reported in connection with senescence-related thymus adipose involution that apparently yields beige adipose tissue.…”