Comparison of Sectoral Structure-Function Relationships in Glaucoma: Vessel Density Versus Thickness in the Peripapillary Retinal Nerve Fiber Layer

Sakaguchi, Kimikazu; Higashide, Tomomi; Udagawa, Sachiko; Ohkubo, Shinji; Sugiyama, Kazuhisa

doi:10.1167/iovs.17-21955

Cited by 52 publications

(61 citation statements)

References 37 publications

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“…19,20 These studies have shown that the floor effects exhibited by OCT-based RNFL parameters, in which increasing VF losses correspond poorly to detectable changes in the measured RNFL thickness, are largely absent from vascular OCT-A parameters. Spatial correlations have also been demonstrated between defects in the VF and vascular density in the corresponding peripapillary regions, using models defined based on hemispherical regions [21][22][23] or sectors [24][25][26][27] from the Garway-Heath map. 28 However, an evaluation of the focal relationships between VF losses and structural and microvasculature measurements at each VF test point has yet to be reported.…”

mentioning

confidence: 99%

Focal Structure–Function Relationships in Primary Open-Angle Glaucoma Using OCT and OCT-A Measurements

Wong¹,

Chua

Lin

et al. 2020

Invest. Ophthalmol. Vis. Sci.

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mentioning

confidence: 99%

Focal Structure–Function Relationships in Primary Open-Angle Glaucoma Using OCT and OCT-A Measurements

Wong¹,

Chua

Lin

et al. 2020

Invest. Ophthalmol. Vis. Sci.

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“…The sectoral VF CMS was adapted from the structure-function correspondence map suggested by Garway-Heath et al [ 22 ] ( Fig 1 ). Prior studies have investigated the sectoral correlation between peripapillary VD and VF loss using the Garway-Heath map and found strong correlation in the infero-temporal (IT), temporal, infero-nasal and supero-temporal (ST) sectors, similar to the correlation between RNFL thickness and VF loss [ 29 , 30 ]. In our study, sectoral macular vascular microcirculation was significantly correlated with sectoral VF CMS in all sectors except for the inferonasal VF CMS with supero-temporal GCIPL blood flow parameters.…”

Section: Discussionmentioning

confidence: 97%

Macular microvascular parameters in the ganglion cell-inner plexiform layer derived by optical coherence tomography angiography: Vascular structure-central visual function analysis

et al. 2020

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To investigate the relationships between global and sectoral macular vascular microcirculation parameters in the ganglion cell-inner plexiform layer (GCIPL) assessed by optical coherence tomography angiography (OCTA), and global and sectoral visual field (VF) central mean sensitivity (CMS) assessed by standard automated perimetry. Methods Fifty-four eyes with open angle glaucoma were scanned using a swept-source OCTA (Plex Elite 9000, Zeiss, Dublin, CA) and macular vascular microcirculation was measured by calculating the overall flux and vessel area density (VAD) over the entire 6mm x 6mm area, excluding large retinal vessels. Central 10-degree VF CMS was calculated based on 24-2 VF. Pearson correlation was used to investigate the correlation between global and sectoral OCTA parameters and global and sectoral VF CMS. Results Both global GCIPL flux and VAD were significantly correlated with VF CMS (p<0.001). For the sectoral analysis, sectoral VAD was significantly correlated with sectoral VF CMS in all comparisons except for the inferonasal VF CMS with supero-temporal (ST) GCIPL VAD (p = 0.097). Although highest correlation was observed for both ST VF CMS with inferior GCIPL VAD and infero-temporal VF CMS with superior GCIPL VAD (r = 0.683, p<0.001), there was no significant difference in correlation when compared to the global VAD and other sectors' correlation coefficients (p� 0.091), except for the ST GCIPL VAD (p = 0.001).

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“…For instance, Sakaguchi and al. [ 25 ] have recently demonstrated that peripapillary RNFL vessel density and thickness had different characteristic sectoral structure-function relationships in glaucoma. An RNFL vessel density measurement must take into account the presence of peripapillary atrophy, hence the importance of precise segmentation of the region of interest such as the one provided by the approach introduced in this article.…”

Section: Discussionmentioning

confidence: 99%

“…Analyses of 2D vascular networks have been described in numerous publications [ 2 – 25 ]. Parameters such as the vascular density in terms of the skeleton of vessels, diameter of vessels, perimeter and tortuosity have been demonstrated to be correlated with lesions.…”

Section: Introductionmentioning

confidence: 99%

Toward quantitative and reproducible clinical use of OCT-Angiography

et al. 2018

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Optical coherence tomography angiography (OCT-A) is an ophthalmic imaging technique which has recently been introduced to clinical use. OCT-A provides visualization of the retinal vascularization in three dimensions, without injection of contrast agents. OCT-A could thus replace the current standard of opthalmic imaging, which is 2D only and requires contrast agents. However, quantitative studies remain to be carried out to assess the full potential of OCT-A. In this context, the present work proposes a methodology to perform OCT-A in a more reproducible and precise way. We introduce a procedure to automatically extract the area of interest in avascular regions, which we demonstrate on various avascular areas with a focus on the optic nerve extracted in 2-dimensional images for a selected depth. We then study the repeatability of OCT-A with our segmentation technique when implemented on various clinical devices. For illustration, we apply this segmentation to healthy control group and to patients presenting different stages of glaucoma, a disease of clinical interest. The variability observed between these two cohorts compares favorably to the variability due to instrumental limitations or the segmentation algorithm. Our results thus constitute a significant step toward a more quantitative use of OCT-A in a clinical context.

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Comparison of Sectoral Structure-Function Relationships in Glaucoma: Vessel Density Versus Thickness in the Peripapillary Retinal Nerve Fiber Layer

Abstract: Peripapillary RNFL VD and thickness have different characteristic sectoral structure-function relationships in glaucoma.

Cited by 52 publications

References 37 publications

Focal Structure–Function Relationships in Primary Open-Angle Glaucoma Using OCT and OCT-A Measurements

Focal Structure–Function Relationships in Primary Open-Angle Glaucoma Using OCT and OCT-A Measurements

Macular microvascular parameters in the ganglion cell-inner plexiform layer derived by optical coherence tomography angiography: Vascular structure-central visual function analysis

Toward quantitative and reproducible clinical use of OCT-Angiography

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