Comparison of salivary nitric oxide and epidermal growth factor level between diabetic patients and healthy individuals

Abdolsamadi, Hamid Reza; Rezaei, Fatemeh; Goodarzi, Mohammad Taghi; Moghimbeigi, Abbas; Jazaeri, Mina; Asadi, Sara; Ahmadi‐Motamayel, Fatemeh

doi:10.1007/s13410-014-0207-x

Cited by 10 publications

(9 citation statements)

References 39 publications

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“…It contains composition such as has inflammatory mediators that play important role in oral health. Saliva composition, naturally or under certain conditions, varies in different individuals [ 33 , 34 ]. The relationship between some inflammatory mediators in saliva and periodontitis pathogenesis has been established in some studies.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Scaling and Root Planning on Salivary TNF-α and IL-1α Concentrations in Patients with Chronic Periodontitis

Eivazi¹,

Falahi²,

Eivazi³

et al. 2017

TODENTJ

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Objective:Periodontitis is one of the main diseases in the oral cavity that causes tooth loss. The host immune response and inflammatory factors have important role in periodontal tissue. The current study was done with the objective to determine the effect of scaling and root planning on the salivary concentrations of tumor necrosis factor-alpha (TNF-α) and interleukin-1-alpha (IL-1α).Methods:In this quasi-experimental clinical trial, 29 patients with chronic periodontitis and 29 healthy subjects without periodontitis were studied. Clinical examination findings and salivary TNF-α and IL-1α (using ELISA method) were compared before and after scaling, root planning.Results:Before starting treatment, salivary TNF-α and IL-1α concentrations were higher in healthy control group than in periodontitis group (P< 0.05). Non-surgical treatment increased the concentration of these two biomarkers in the saliva. However, increase in IL-1α concentration was not statistically significant (P= 0.056). There was a negative relationship between TNF-α and IL-1α levels with pocket depth and attachment loss (P< 0.05).Conclusion:Scaling and root planning improved periodontal disease indices and salivary TNF-α and IL-1α levels.

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Section: Introductionmentioning

confidence: 99%

The Effect of Scaling and Root Planning on Salivary TNF-α and IL-1α Concentrations in Patients with Chronic Periodontitis

Eivazi¹,

Falahi²,

Eivazi³

et al. 2017

TODENTJ

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“…In addition, collecting salivary sample is noninvasive, does not need trained staff, is relatively nonstressful, and changes in environmental conditions such as temperature, movement, and growth of microorganisms do not change salivary cortisol level. [ 8 9 ] So far, limited studies have been done about the relationship between salivary cortisol, as a marker for stress, and RAS. There is controversy among various studies on this topic.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of salivary cortisol changes and psychological profiles in patients with recurrent aphthous stomatitis

2017

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Background and Objective:Some studies suggest that psychological condition and stress can play role in the development of recurrent aphthous stomatitis (RAS). The purpose of this study was to evaluate salivary cortisol changes and psychological conditions in patients with RAS.Materials and Methods:Twenty-seven patients (13 males and 14 females, mean age of 32.8 (±10.2) years) with minor RAS and 27 age- and sex-matched controls without RAS participated in this study. The concentration of cortisol (nanomole/L) was measured in samples of unstimulated saliva from patients and controls two times; once during the presence of active lesions and once again when the lesions had healed by immunologic assay. The Hospital Anxiety and Depression Scale was employed to determine psychological condition. Visual analog scale for pain severity was recorded for patients with active lesions episode. Data were analyzed by the SPSS software (version 18.0) using paired and unpaired t-tests and Pearson correlation coefficient.Results:Salivary cortisol level was lower in patients during active lesions (12.4 ± 5.1) and healing (10.5 ± 3.9) episodes compared to the controls (13.1 ± 3.6) (P = 0.583, P = 0.015; respectively). There was no significant difference in salivary cortisol between active lesions and healing episodes (P = 0.943). Anxiety and depression represented no significant differences between active lesions and healing episodes (P > 0.05). Anxiety and depression levels in patients were significantly higher than in controls (P < 0.05). Pain severity in active lesions was not significantly correlated to salivary cortisol level, and anxiety or depression scores (P > 0.05).Conclusion:The findings showed that occurrence of RAS was associated with anxiety and depression but not with alterations of salivary cortisol level.

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“…Salivary EGF concentration was measured by Crystal Dibiotic assay (made in China) by the ELISA method. [8]…”

Section: Methodsmentioning

confidence: 99%

“…[7] EGF is a single polypeptide with 53 amino acids. [8] Numerous growth factors such as EGF, insulin-like growth factor (IGF), neural growth factor (NGF) and transforming growth factor (TGF) synthesis are secreted through saliva, the most important of which is EGF. Salivary EGF induces the mitotic response of the cell, thereby playing a role in the activation of RNA and synthesis of DNA, protein, and extracellular macromolecules.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of salivary epidermal growth factor in patients with recurrent aphthous stomatitis, smokers, and healthy individuals

Rezaei

Hosseini

Rezaei

2019

J Family Med Prim Care

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Comparison of salivary nitric oxide and epidermal growth factor level between diabetic patients and healthy individuals

Cited by 10 publications

References 39 publications

The Effect of Scaling and Root Planning on Salivary TNF-α and IL-1α Concentrations in Patients with Chronic Periodontitis

The Effect of Scaling and Root Planning on Salivary TNF-α and IL-1α Concentrations in Patients with Chronic Periodontitis

Evaluation of salivary cortisol changes and psychological profiles in patients with recurrent aphthous stomatitis

Comparison of salivary epidermal growth factor in patients with recurrent aphthous stomatitis, smokers, and healthy individuals

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