Comparison of retinal and choroidal changes in Fuchs’ uveitis syndrome

Balci, Ali Safa; Pehlivanoğlu, Seren; Başarır, Berna; Altan, Çiğdem

doi:10.1007/s10792-022-02595-w

Cited by 3 publications

(1 citation statement)

References 25 publications

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“…23 Their ndings were replicated by Balci et al where they also found that 2D CVI was lower in affected eyes in Fuchs uveitis syndrome compared to that of healthy controls. 24 Contrastingly, our group's previous research indicated an elevated 2D CVI in posterior or panuveitis patients. 9 These divergent results may be due to contributing factors such as uveitis aetiological heterogeneity.…”

Section: Discussionmentioning

confidence: 57%

Optical Coherence Tomography-Based Choroidal Vascularity Index: Tracking Uveitis Progression Over Time

Agrawal,

Wei,

Loh

et al. 2024

Preprint

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Objectives To investigate longitudinal changes in choroidal vascularity index (CVI) in uveitis patients with active inflammation at baseline, and at six months. Methods This prospective comparative study included 49 eyes of 49 patients with anterior, intermediate, posterior or panuveitis, and 49 eyes of 49 healthy controls. Uveitis patients were recruited at baseline with active inflammation. Clinical data and multimodal imaging including optical coherence tomography were obtained at baseline and six months. Both two-dimensional (2D) subfoveal CVI and three-dimensional (3D) macular CVI were measured using previously published algorithms. Comparison between uveitis and control group as well as between baseline visit and 6 months visit in the uveitis group were performed using ANCOVA model. Results At baseline, 2D CVI was lower in the uveitis group (62.4% vs 63.8%, p = 0.007) and 3D CVI also showed a lower trend in the uveitis group (62.0% vs 62.8%, p = 0.109) compared to that of healthy subjects. Within the uveitis group, both 2D and 3D CVI were higher at 6 months compared to baseline, but both were not significant (p = 0.055 and 0.177, respectively). Uveitis patients who were still clinically active at 6 months had lower 2D and 3D CVI at baseline compared to those who were clinically quiescent at 6 months (p = 0.027 and p = 0.008, respectively). Conclusions Changes in CVI are correlated with the diagnosis and prognosis of uveitis patients. Lower CVI values at baseline were associated with persistent inflammation after 6 months of follow-up. Thus, CVI may be a useful outcome measure in uveitis management and clinical trials.

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Section: Discussionmentioning

confidence: 57%

Optical Coherence Tomography-Based Choroidal Vascularity Index: Tracking Uveitis Progression Over Time

Agrawal,

Wei,

Loh

et al. 2024

Preprint

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Retinal and choroidal thickness in fuchs uveitis syndrome: a contralateral eye study

Kianersi,

Taheri,

Mirmohammadkhani

et al. 2024

BMC Ophthalmol

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Background To investigate the subfoveal retinal and choroidal thickness in patients with unilateral Fuchs Uveitis Syndrome (FUS). Methods This comparative contralateral study was performed in affected eyes with FUS versus fellow eyes. For each eye parameters such as subfoveal choroidal thickness (SCT), subfoveal choriocapillary thickness (SCCT), central macular thickness (CMT), and central macular volume (CMV) were measured; then the measured values of affected and fellow unaffected eye were compared. Results Thirty-seven patients (74 eyes) including 19 females (51.4%) with a mean age of 36.9 ± 7.6 years were enrolled. The mean SCT was lower in the affected eyes (344.51 ± 91.67) than in the fellow (375.59 ± 87.33) with adjusting for duration of disease and axial lengths (P < 0.001). The mean SCCT, CMT, and CMV were higher in eyes with FUS than in fellow eyes (P < 0.05). Conclusions The result of our study demonstrated that affected eyes in patients with FUS tend to have thinner SCT and thicker SCCT and CMT compared to uninvolved fellow eyes.

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Short-term Effect of Strabismus Surgery on Choroidal Vasculature

Guler Alis,

Alis,

Kucuk

et al. 2024

J Pediatr Ophthalmol Strabismus

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Purpose: To investigate the effect of strabismus surgery on choroidal structure using the binarization method. Methods: Forty-two eyes of 27 patients who had surgery for horizontal strabismus were included in the study. Optical coherence tomography (OCT) images of the patients before the operation and at 1 day and 1 week after the operation were binarized. Total choroidal area (TCA), stromal area (SA), luminal area (LA), and choroidal vascularity index (CVI) were calculated and compared. Results: The mean age of the patients was 16.7 ± 13.5 years; 12 were female, and 15 were male. The mean spherical equivalent was 0.125 ± 0.50 diopters (D). The mean axial length value was 23.3 ± 1.3 mm. Preoperative TCA was 599686 ± 113451, LA was 394259 ± 67259, SA was 209180 ± 47723, and CVI was 0.66 ± 0.02. At 1 day postoperatively, TCA was 615575 ± 103686, LA was 395364 ± 60314, SA was 218418 ± 45620, and CVI was 0.65 ± 0.02. At 1 week postoperatively, TCA was 610997 ± 110578, LA was 394002 ± 65186, SA was 214995 ± 46481, and CVI was 0.66 ± 0.04. A statistically significant decrease in CVI and increase in TCA and SA were observed on the first postoperative day; these changes were observed as returning to preoperative values at 1 week postoperatively. Conclusions: Strabismus surgery temporarily decreases the CVI by increasing the SA of the choroidal layer, possibly due to hemodynamic changes and/or inflammatory causes in the early period. [ J Pediatr Ophthalmol Strabismus . 20XX;X(X):XX–XX.]

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Comparison of retinal and choroidal changes in Fuchs’ uveitis syndrome

Cited by 3 publications

References 25 publications

Optical Coherence Tomography-Based Choroidal Vascularity Index: Tracking Uveitis Progression Over Time

Optical Coherence Tomography-Based Choroidal Vascularity Index: Tracking Uveitis Progression Over Time

Retinal and choroidal thickness in fuchs uveitis syndrome: a contralateral eye study

Short-term Effect of Strabismus Surgery on Choroidal Vasculature

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