Comparison of QT dispersion in hypertrophic cardiomyopathy between patients with and without ventricular arrhythmias and sudden death

Buja, Gianfranco; Miorelli, Manuela; Turrini, Pietro; Melacini, Paola; Nava, Andrea

doi:10.1016/0002-9149(93)91118-2

Cited by 353 publications

(160 citation statements)

References 15 publications

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“…QT dispersion and cardiac disease: Increased QT dispersion reflects electrical inhomogeneity, which may occur as a result of myocardial ischemia, mitral valve prolapse, ventricular hypertrophy or dilatation, autonomic neuropathy, peripheral vascular disease, and hypertension. [9][10][11][12][13][14][15] A recent study, which analyzed the 12-lead electrocardiograms of 1501 healthy adults and 1784 healthy children found that QTd was age and sex independent.…”

Section: Discussionmentioning

confidence: 99%

QT Dispersion in Patients with Polycystic Ovary Syndrome.

et al. 2002

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SUMMARYCardiac risk factors are observed more frequently in patients with polycystic ovary syndrome (PCOS). On the other hand, increased QT dispersion, which is a risk factor for cardiac arrhythmias and sudden death, has not been investigated in this syndrome. In this study, we evaluated QT dispersion in PCOS patients without overt heart disease. Thirtysix consecutive women with PCOS (mean age 24±5 years) and 36 healthy women of similar ages (mean age 24±4 years) participated in this study. PCOS was diagnosed if there were polycystic ovaries by ultrasound (enlarged ovaries with ≥8 cysts 2-8 mm in diameter), oligoamenorrhea (intermenstrual interval >35 days), hirsutism (Ferriman-Gallwey score, ≥7) and elevated serum levels of testosterone (≥2.7 nmol/L). Electrocardiograms were recorded at a paper speed of 50 mm/s. QT intervals were manually measured by a cardiologist. All intervals were corrected for heart rate according to Bazett's formula: QTc interval=QT interval/square root of the RR interval. Mean values of body mass index, heart rate, and blood pressure were not significantly different between the two groups (P>0.05). No significant differences in QT intervals (maximum QT, minimum QT, QT dispersion, minimum corrected QT, maximum corrected QT, and corrected QT dispersion) were observed between the two groups (P>0.05). Our results suggest that the risk of ventricular arrhythmias or sudden cardiac death is not increased in PCOS patients. (Jpn Heart J 2002; 43: 487-493) Key words: Electrocardiography, Polycystic ovary syndrome, QT dispersion POLYCYSTIC ovary syndrome (PCOS) is a disorder of chronic anovulation, hyperandrogenism, hirsutism, obesity, subfertility, hyperlipidemia, and insulin resistance. Infertility is not the only important component of this syndrome, since the risks of cardiac disease and hypertension also increase in women with PCOS.1-3) Insulin resistance and hyperinsulinemia appear central to the pathophysiology of PCOS. Glucose intolerance, abnormally high fasting serum lipid concentrations, and high blood pressure are the three cardiac risk factors that have From the

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Section: Discussionmentioning

confidence: 99%

QT Dispersion in Patients with Polycystic Ovary Syndrome.

et al. 2002

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“…On the other hand, increased QT dispersion in the 12-lead surface electrocardiogram has been associated with ventricular arrhythmias and sudden cardiac death in a variety of cardiac diseases. [4][5][6][7][8] The relationships between QT dispersion, LVH, complex ventricular arrhythmias and sudden cardiac death over long-term follow-up in hypertensive patients has not been studied previously. The aim of this study therefore was to examine the prognostic significance of these parameters in previously untreated patients.…”

Section: Introductionmentioning

confidence: 99%

Predictors of sudden cardiac death in never previously treated patients with essential hypertension: long-term follow-up

Saadeh

Jones

2001

J Hum Hypertens

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Increased QT dispersion has been associated with ventricular arrhythmia and sudden death in a variety of cardiac disorders. Left ventricular hypertrophy (LVH) has also been associated with increased incidence of sudden cardiac death in patients with essential hypertension. Furthermore, patients with essential hypertension, particularly those with LVH, are more likely to develop ventricular arrhythmias than are the normal population. The relationship between LVH, QT dispersion, complex ventricular arrhythmia and sudden cardiac death in previously untreated patients over long-term follow-up in hypertension has not been reported before and is the purpose of this study. Fifty-nine adult subjects with essential hypertension, who had never been previously on antihypertensive treatment were followed up for a total of 119.2 ؎ 26.2 months. QTc (corrected QT), blood pressure, electrocardiograms, and 24-h Holter ECG recordings were performed in all patients at the time of entry to the study. Ventricular arrhythmias were classi-

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“…[11][12][13][14][15] To a lesser extent, patients with hypertension, particularly those with LVH, are also at increased risk of premature cardiac death, much of which is sudden. Although the ventricular arrhythmias in hypertension have previously been correlated with the presence of LVH, 1,7,[22][23][24] no such positive correlation was found in our patients.…”

Section: Discussionmentioning

confidence: 99%

“…15 As far as we are aware, there have been no studies on the possible pathogenic role of QT dispersion on ventricular arrhythmias occurring in never-treated hypertensive patients.…”

Section: Introductionmentioning

confidence: 99%

QTc dispersion and complex ventricular arrhythmias in untreated newly presenting hypertensive patients

Saadeh

Metcalfe

et al. 1999

J Hum Hypertens

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Increased dispersion of ventricular repolarisation (increased QT dispersion) is believed to predispose to arrhythmias associated with sudden death in certain cardiac diseases. Hypertension is also associated with increased risk of sudden death, particularly in those with left ventricular hypertrophy (LVH). Therefore, the first aim of this study is to look into the possible pathogenic role of QT dispersion on the ventricular arrhythmias occurring in a group of never-treated hypertensive patients. The second aim is to look at other possible determinants of QT dispersion (ie, level of blood pressure, hypokalaemia, electrocardiographic LVH and presence or absence of strain pattern) in hypertensive patients, and their relevance to complex ventricular arrhythmias.QTc (corrected QT) was measured in 70 newly presenting (never-treated) hypertensive patients (47 male, 23 female, mean age 51.9 ؎ 12.5 years) from a standard 12-lead surface electrocardiogram (ECG). Blood pressure measurements and 24-h ECG holter recordings were performed in all patients. Serum potassium level was measured in 51 of the patients. Ventricular arrhythmias were classified using a modified Lown's scoring system. Maximum QTc, minimum QTc and QTc dispersion for all patients were 442 ؎ 30.3 ms, 380 ؎ 26.7 ms and 61.5 ؎ 21.6 ms respectively. High grade ventricular

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Comparison of QT dispersion in hypertrophic cardiomyopathy between patients with and without ventricular arrhythmias and sudden death

Cited by 353 publications

References 15 publications

QT Dispersion in Patients with Polycystic Ovary Syndrome.

QT Dispersion in Patients with Polycystic Ovary Syndrome.

Predictors of sudden cardiac death in never previously treated patients with essential hypertension: long-term follow-up

QTc dispersion and complex ventricular arrhythmias in untreated newly presenting hypertensive patients

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