Comparison of Propofol and Midazolam for Sedation in Critically Ill Patients

Aitkenhead, A. R.; Willatts, Sheila M.; Park, GilbertR.; Collins, CharlesH.; Ledingham, I. McA.; Pepperman, M. L.; Coates, P. David; Bodenham, A.; Smith, M. B.; Wallace, PeterG.M.

doi:10.1016/s0140-6736(89)90770-8

Cited by 197 publications

(81 citation statements)

References 26 publications

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“…Aprks la physioth~rapie, le dosage de midazolam n~cessite 1,8 -t-0.5 ajustements comparativement ~ 0,4 + O,2 pour le propofol (P < 0,05). Pendant la physioth~rapie, la posologie du propofol doit ~tre ajustde 3,5 fois comparativement ~ 3,5 pour celle du midazolam (NS) Most patients admitted to intensive care units, who are subsequently ventilated artificially, require some form of sedation during at least part of their stay and it is common practice to use either midazolam or propofol by continuous intravenous infusion. It has been shown t-6 that over a 24-hr period both midazolam and propofol offer good quality of sedation and that the quicker wake up time that is seen with propofol may mean that this agent has benefits over midazolam.…”

Section: It Is Often Necessary To Adjust a Patientmentioning

confidence: 99%

“…Although most studies have shown little difference between propofol or midazolam as far as cardiovascular changes are concerned, 3,5,6 one study has suggested that there may be a greater hypotensive effect associated with the use of propofol than with midazolam. 12 The lack of difference in these cardiovascular variables between the two groups in our study confirms the majority of earlier studies showing no difference between propofol and midazolam.…”

Section: Propofol Midazolammentioning

confidence: 99%

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Propofol or midazolam for short-term alterations in sedation

Boyd

Rushmer

et al. 1993

Can J Anaesth

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It is often necessary to adjust a patient (92,8 -1-35,0 rain, P < 0,05). Aprks la physioth~rapie, le dosage de midazolam n~cessite 1,8 -t-0.5 ajustements comparativement ~ 0,4 + O,2 pour le propofol (P < 0,05). Pendant la physioth~rapie, la posologie du propofol doit ~tre ajustde 3,5 fois comparativement ~ 3,5 pour celle du midazolam (NS) Most patients admitted to intensive care units, who are subsequently ventilated artificially, require some form of sedation during at least part of their stay and it is common practice to use either midazolam or propofol by continuous intravenous infusion. It has been shown t-6 that over a 24-hr period both midazolam and propofol offer good quality of sedation and that the quicker wake up time that is seen with propofol may mean that this agent has benefits over midazolam. These studies, however, CANJ ANAESTH 1993 / 40:12 / pp 1142

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Section: It Is Often Necessary To Adjust a Patientmentioning

confidence: 99%

Section: Propofol Midazolammentioning

confidence: 99%

Propofol or midazolam for short-term alterations in sedation

Boyd

Rushmer

et al. 1993

Can J Anaesth

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“…In addition, critically ill patients were found to be more sensitive to the physiologic depressant effects of propofol, suggesting a need for further investigation in this area. Grounds et al (36) and Aitkenhead et al (37) reported similar results when they compared the use of propofol to midazolam for postoperative patients. Sedation was adequate in both groups, but recovery was less variable with propofol.…”

Section: Sedationmentioning

confidence: 77%

Propofol: A New IV Anesthetic and Sedation Agent

Fox

Hellman

Lamberth

et al. 1990

Baylor University Medical Center Proceedings

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A review of the pharmacology, physiology, and clinical uses of propofol, a new intravenous anesthetic agent, is presented. Propofol, a sterically hindered phenol solubilized in a soybean emulsion, is unlike any other anesthetic or sedation agent used to date. Its rapid metabolism and clearance allow a quick and clearheaded recovery, suggesting that propofol would be ideal for outpatient sedation and anesthesia and as a total intravenous anesthetic agent. Postoperative side effects are decreased with its use. As with many other induction agents, propofol can cause a drop in arterial blood pressure and cardiac output, and therefore should be used with care in patients with coronary artery disease.

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“…Paralelamente, o propofol pode reduzir a concentração plasmática de cortisol, sobretudo em função do potencial sedativo conferido por esse fármaco, atenuando a resposta simpática ao estresse, de modo a minimizar a liberação de catecolaminas (Aitkenhead et al, 1989). Em estudo realizado no homem, foi demonstrada redução da concentração sérica de cortisol, após a indução anestésica com propofol (Zhang et al, 2000).…”

Section: Discussionunclassified

Anestesia epidural com lidocaína isolada e associada ao fentanil para realização de ováriossalpingo-histerectomia em cadelas

Cassu

Stevanin

Kanashiro

et al. 2008

Arq. Bras. Med. Vet. Zootec.

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RESUMOInvestigou-se o efeito da lidocaína isolada ou associada ao fentanil na anestesia epidural, para realização de ováriossalpingo-histerectomia. Dezoito cadelas foram tranqüilizadas com acepromazina, seguindo-se indução anestésica com propofol, para a realização da punção lombossacra. Os animais foram distribuídos em dois grupos: o grupo GL recebeu lidocaína (8,5mg/kg) e o GLF fentanil (5µg/kg) associado à lidocaína (6,5mg/kg). Mensuraram-se as freqüências cardíaca (FC) e respiratória (FR), pressão arterial sistólica (PAS), variáveis hemogasométricas, concentração sérica de cortisol, necessidade de complementação anestésica com propofol durante a cirurgia, temperatura retal (T), período de latência e duração do bloqueio anestésico. Foi observada redução na FC, FR e PAS no GL e GLF, porém esses parâmetros mantiveram-se dentro dos limites fisiológicos. Para ambos os grupos, a concentração sérica de cortisol manteve-se estável após a cirurgia. Complementação anestésica foi necessária em 40% e 75% dos animais do GLF e GL, respectivamente. Conclui-se que ambos os protocolos foram suficientes para inibir a elevação sérica do cortisol, e resultaram em alterações mínimas cardiorrespiratórias, e que a complementação anestésica foi necessária.

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Comparison of Propofol and Midazolam for Sedation in Critically Ill Patients

Cited by 197 publications

References 26 publications

Propofol or midazolam for short-term alterations in sedation

Propofol or midazolam for short-term alterations in sedation

Propofol: A New IV Anesthetic and Sedation Agent

Anestesia epidural com lidocaína isolada e associada ao fentanil para realização de ováriossalpingo-histerectomia em cadelas

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