Comparison of preoperative and postoperative diflunisal for suppression of postoperative pain

A comparison of pre-emptive analgesic efficacy of diflunisal and lornoxicam for postoperative pain management: a prospective, randomized, single-blind, crossover study

“…The present study revealed a significantly low incidence of adverse effects of the administration of both diflunisal and lornoxicam. This is consistent with other studies carried out with similar doses of oral diflunisal and lornoxicam 14,20 .…”

A comparison of pre-emptive analgesic efficacy of diflunisal and lornoxicam for postoperative pain management: a prospective, randomized, single-blind, crossover study

“…The present study revealed a significantly low incidence of adverse effects of the administration of both diflunisal and lornoxicam. This is consistent with other studies carried out with similar doses of oral diflunisal and lornoxicam 14,20 .…”

Does the Preemptive Use of Oral Nonsteroidal Anti-inflammatory Drugs Reduce Postoperative Pain in Surgical Removal of Third Molars? A Meta-analysis of Randomized Clinical Trials

“…Therefore, a total of 6 articles were selected for the systematized review. 7,[9][10][11]14,15 All of the studies dealt with randomized, double-blinded, and placebocontrolled clinical trials, and only 2 studies were crossed. 9,15 The researched studies were published in the period from 1989 through 2012 (Table 1) and included a total of 420 participants, among them 171 men and 249 women, with a mean age ranging from 18.1 to 27.9 years, showing that all of the participants were young adults.…”

“…7,[9][10][11]14,15 All of the studies dealt with randomized, double-blinded, and placebocontrolled clinical trials, and only 2 studies were crossed. 9,15 The researched studies were published in the period from 1989 through 2012 (Table 1) and included a total of 420 participants, among them 171 men and 249 women, with a mean age ranging from 18.1 to 27.9 years, showing that all of the participants were young adults. Three authors related the mean time of the surgical procedure (third-molar removal) in minutes: Al-Sukhun et al 14 performed the procedure in 30.9 minutes, Aznar-Arasa et al 10 Lidocaine (2%) was the basic anesthetic used by 3 authors, 9,11,14 and the vasoconstrictor used in the anesthetic solution was epinephrine 1:80,000, 14 norepinephrine 1:80,000, 11 and epinephrine 1:100,000.…”

“…9,15 The researched studies were published in the period from 1989 through 2012 (Table 1) and included a total of 420 participants, among them 171 men and 249 women, with a mean age ranging from 18.1 to 27.9 years, showing that all of the participants were young adults. Three authors related the mean time of the surgical procedure (third-molar removal) in minutes: Al-Sukhun et al 14 performed the procedure in 30.9 minutes, Aznar-Arasa et al 10 Lidocaine (2%) was the basic anesthetic used by 3 authors, 9,11,14 and the vasoconstrictor used in the anesthetic solution was epinephrine 1:80,000, 14 norepinephrine 1:80,000, 11 and epinephrine 1:100,000. 9 The authors Aznar-Arasa et al 10 and Kaczmarzyk et al 7 used 4% articaine with epinephrine 1:100,000 and 1:200,000, respectively; Sisk and Grover 8 did not disclose the anesthetic solution used.…”

“…Sisk and Grover 8 used naproxen sodium 550 mg 30 minutes before with placebo 30 min after surgery in 30 patients on one side of the mouth and placebo 30 min before with naproxen sodium 550 mg 30 min after the surgical procedure on the other side of the mouth, in the same patients. Sisk et al 9 used sodium diflunisal 1000 mg 30 min before with placebo 30 min after surgery in 20 patients on one side of the mouth and placebo 30 min before with diflunisal 1000 mg 30 min after the procedure on the other side of the mouth, in the same patients. The NSAIDs were associated with the appearance of adverse effects as reported by Al-Sukhun et al, 14 Sisk et al, 9 and Sisk and Grover.…”

A comparison of pre-emptive analgesic efficacy of diflunisal and lornoxicam for postoperative pain management: a prospective, randomized, single-blind, crossover study

“…The present study revealed a significantly low incidence of adverse effects of the administration of both diflunisal and lornoxicam. This is consistent with other studies carried out with similar doses of oral diflunisal and lornoxicam 14,20 .…”

Does the Preemptive Use of Oral Nonsteroidal Anti-inflammatory Drugs Reduce Postoperative Pain in Surgical Removal of Third Molars? A Meta-analysis of Randomized Clinical Trials

“…Therefore, a total of 6 articles were selected for the systematized review. 7,[9][10][11]14,15 All of the studies dealt with randomized, double-blinded, and placebocontrolled clinical trials, and only 2 studies were crossed. 9,15 The researched studies were published in the period from 1989 through 2012 (Table 1) and included a total of 420 participants, among them 171 men and 249 women, with a mean age ranging from 18.1 to 27.9 years, showing that all of the participants were young adults.…”

“…7,[9][10][11]14,15 All of the studies dealt with randomized, double-blinded, and placebocontrolled clinical trials, and only 2 studies were crossed. 9,15 The researched studies were published in the period from 1989 through 2012 (Table 1) and included a total of 420 participants, among them 171 men and 249 women, with a mean age ranging from 18.1 to 27.9 years, showing that all of the participants were young adults. Three authors related the mean time of the surgical procedure (third-molar removal) in minutes: Al-Sukhun et al 14 performed the procedure in 30.9 minutes, Aznar-Arasa et al 10 Lidocaine (2%) was the basic anesthetic used by 3 authors, 9,11,14 and the vasoconstrictor used in the anesthetic solution was epinephrine 1:80,000, 14 norepinephrine 1:80,000, 11 and epinephrine 1:100,000.…”

“…9,15 The researched studies were published in the period from 1989 through 2012 (Table 1) and included a total of 420 participants, among them 171 men and 249 women, with a mean age ranging from 18.1 to 27.9 years, showing that all of the participants were young adults. Three authors related the mean time of the surgical procedure (third-molar removal) in minutes: Al-Sukhun et al 14 performed the procedure in 30.9 minutes, Aznar-Arasa et al 10 Lidocaine (2%) was the basic anesthetic used by 3 authors, 9,11,14 and the vasoconstrictor used in the anesthetic solution was epinephrine 1:80,000, 14 norepinephrine 1:80,000, 11 and epinephrine 1:100,000. 9 The authors Aznar-Arasa et al 10 and Kaczmarzyk et al 7 used 4% articaine with epinephrine 1:100,000 and 1:200,000, respectively; Sisk and Grover 8 did not disclose the anesthetic solution used.…”

“…Sisk and Grover 8 used naproxen sodium 550 mg 30 minutes before with placebo 30 min after surgery in 30 patients on one side of the mouth and placebo 30 min before with naproxen sodium 550 mg 30 min after the surgical procedure on the other side of the mouth, in the same patients. Sisk et al 9 used sodium diflunisal 1000 mg 30 min before with placebo 30 min after surgery in 20 patients on one side of the mouth and placebo 30 min before with diflunisal 1000 mg 30 min after the procedure on the other side of the mouth, in the same patients. The NSAIDs were associated with the appearance of adverse effects as reported by Al-Sukhun et al, 14 Sisk et al, 9 and Sisk and Grover.…”

A comparison of pre-emptive analgesic efficacy of diflunisal and lornoxicam for postoperative pain management: a prospective, randomized, single-blind, crossover study

“…The present study revealed a significantly low incidence of adverse effects of the administration of both diflunisal and lornoxicam. This is consistent with other studies carried out with similar doses of oral diflunisal and lornoxicam 14,20 .…”

Does the Preemptive Use of Oral Nonsteroidal Anti-inflammatory Drugs Reduce Postoperative Pain in Surgical Removal of Third Molars? A Meta-analysis of Randomized Clinical Trials

“…Therefore, a total of 6 articles were selected for the systematized review. 7,[9][10][11]14,15 All of the studies dealt with randomized, double-blinded, and placebocontrolled clinical trials, and only 2 studies were crossed. 9,15 The researched studies were published in the period from 1989 through 2012 (Table 1) and included a total of 420 participants, among them 171 men and 249 women, with a mean age ranging from 18.1 to 27.9 years, showing that all of the participants were young adults.…”

“…7,[9][10][11]14,15 All of the studies dealt with randomized, double-blinded, and placebocontrolled clinical trials, and only 2 studies were crossed. 9,15 The researched studies were published in the period from 1989 through 2012 (Table 1) and included a total of 420 participants, among them 171 men and 249 women, with a mean age ranging from 18.1 to 27.9 years, showing that all of the participants were young adults. Three authors related the mean time of the surgical procedure (third-molar removal) in minutes: Al-Sukhun et al 14 performed the procedure in 30.9 minutes, Aznar-Arasa et al 10 Lidocaine (2%) was the basic anesthetic used by 3 authors, 9,11,14 and the vasoconstrictor used in the anesthetic solution was epinephrine 1:80,000, 14 norepinephrine 1:80,000, 11 and epinephrine 1:100,000.…”

“…9,15 The researched studies were published in the period from 1989 through 2012 (Table 1) and included a total of 420 participants, among them 171 men and 249 women, with a mean age ranging from 18.1 to 27.9 years, showing that all of the participants were young adults. Three authors related the mean time of the surgical procedure (third-molar removal) in minutes: Al-Sukhun et al 14 performed the procedure in 30.9 minutes, Aznar-Arasa et al 10 Lidocaine (2%) was the basic anesthetic used by 3 authors, 9,11,14 and the vasoconstrictor used in the anesthetic solution was epinephrine 1:80,000, 14 norepinephrine 1:80,000, 11 and epinephrine 1:100,000. 9 The authors Aznar-Arasa et al 10 and Kaczmarzyk et al 7 used 4% articaine with epinephrine 1:100,000 and 1:200,000, respectively; Sisk and Grover 8 did not disclose the anesthetic solution used.…”

“…Sisk and Grover 8 used naproxen sodium 550 mg 30 minutes before with placebo 30 min after surgery in 30 patients on one side of the mouth and placebo 30 min before with naproxen sodium 550 mg 30 min after the surgical procedure on the other side of the mouth, in the same patients. Sisk et al 9 used sodium diflunisal 1000 mg 30 min before with placebo 30 min after surgery in 20 patients on one side of the mouth and placebo 30 min before with diflunisal 1000 mg 30 min after the procedure on the other side of the mouth, in the same patients. The NSAIDs were associated with the appearance of adverse effects as reported by Al-Sukhun et al, 14 Sisk et al, 9 and Sisk and Grover.…”