Comparison of porcine and human adipose tissue loading responses under dynamic compression and shear: A pilot study

Sun, Zhaonan; Lee, Sang-Hyun; Gepner, Bronisław; Rigby, Joshua; Hallman, Jason J.; Kerrigan, Jason

doi:10.1016/j.jmbbm.2020.104112

Cited by 21 publications

(12 citation statements)

References 26 publications

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“…Focusing on adipose tissue, Sun et al (2021c) used dynamic compression and simple shear loading tests to compare human abdominal and porcine adipose tissues. The tissue was found to be non-linear and could be modeled as a one-term Ogden hyperelastic material.…”

Section: Breast Tissue: Basic Concepts and Mechanical Propertiesmentioning

confidence: 99%

A review of bioengineering techniques applied to breast tissue: Mechanical properties, tissue engineering and finite element analysis

Teixeira

Martins

2023

Front. Bioeng. Biotechnol.

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Female breast cancer was the most prevalent cancer worldwide in 2020, according to the Global Cancer Observatory. As a prophylactic measure or as a treatment, mastectomy and lumpectomy are often performed at women. Following these surgeries, women normally do a breast reconstruction to minimize the impact on their physical appearance and, hence, on their mental health, associated with self-image issues. Nowadays, breast reconstruction is based on autologous tissues or implants, which both have disadvantages, such as volume loss over time or capsular contracture, respectively. Tissue engineering and regenerative medicine can bring better solutions and overcome these current limitations. Even though more knowledge needs to be acquired, the combination of biomaterial scaffolds and autologous cells appears to be a promising approach for breast reconstruction. With the growth and improvement of additive manufacturing, three dimensional (3D) printing has been demonstrating a lot of potential to produce complex scaffolds with high resolution. Natural and synthetic materials have been studied in this context and seeded mainly with adipose derived stem cells (ADSCs) since they have a high capability of differentiation. The scaffold must mimic the environment of the extracellular matrix (ECM) of the native tissue, being a structural support for cells to adhere, proliferate and migrate. Hydrogels (e.g., gelatin, alginate, collagen, and fibrin) have been a biomaterial widely studied for this purpose since their matrix resembles the natural ECM of the native tissues. A powerful tool that can be used in parallel with experimental techniques is finite element (FE) modeling, which can aid the measurement of mechanical properties of either breast tissues or scaffolds. FE models may help in the simulation of the whole breast or scaffold under different conditions, predicting what might happen in real life. Therefore, this review gives an overall summary concerning the human breast, specifically its mechanical properties using experimental and FE analysis, and the tissue engineering approaches to regenerate this particular tissue, along with FE models.

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Section: Breast Tissue: Basic Concepts and Mechanical Propertiesmentioning

confidence: 99%

A review of bioengineering techniques applied to breast tissue: Mechanical properties, tissue engineering and finite element analysis

Teixeira

Martins

2023

Front. Bioeng. Biotechnol.

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“…Compression to high strains (some up to ∼ 60%) led to reversible deformation within the elastic region even with nonlinearity of the σ-ε curves (visco- and hyperelasticity of most biological materials [40, 46, 47]). Ad had drastically lower σ and its derivative (dσ/dε) compared to both Fb’s (Fig.…”

Section: Resultsmentioning

confidence: 99%

Reduced fibrous capsule elastic fibers from biologic ECM-enveloped CIEDs in minipigs, supported with a novel compression mechanics model

Guzman

Meer

Mathews

et al. 2022

Preprint

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BACKGROUND: Fibrous capsules (Fb) in response to cardiovascular implantable electronic devices (CIEDs) including a pacemaker (P) system, can produce patient discomfort and difficulties in revision surgery due to their high compressive strength, potentially via elevated elastic fibers. OBJECTIVE: To determine if biologic extracellular matrix-enveloped CIEDs (PECM) caused differential Fb properties. METHODS: Retrieved Fb (-P and -PECM) from minipigs were subjected to biomechanical (shear oscillation and uniaxial compression) and histological (collagen I and elastin) analyzes. RESULTS: Fb-PECM showed significant decreases compared to Fb-P at: low strain-loss modulus (390 vs. 541 Pa) across angular frequencies, high strain-compressive elastic modulus (1043 vs. 2042 kPa), and elastic fiber content (1.92 vs. 3.15 μg/mg tissue), particularly closer to the implant's surface (71% vs. 143% relative to skin dermis elastin) and verified with a solid mechanics hyperelasticity with direction-dependent fiber viscoelasticity compression simulation (r2 ≥ 98.9%). CONCLUSIONS: The biocompatible wrap composed of decellularized porcine ECM for CIEDs generated fibrous tissues with less elastic fibers which contributed to a more desirable material mechanics.

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“…With a value of about 2.5 kPa, Sommer et al found the Cauchy stress of human abdominal adipose tissue at a tensile stretch of 15% to be about 25 times higher than the Cauchy stress of 0.1 kPa observed by Comley and Fleck for porcine subcutaneous adipose tissue at the same tensile stretch [ 27 , 40 ]. Sun et al, in contrast, tested human abdominal and porcine dorsal adipose tissue under uniaxial compression and simple shear at a strain rate of 3 s −1 and found that the porcine tissue behaved stiffer for both loading scenarios [ 31 ]. Nevertheless, the microstructure of human and porcine subcutaneous tissue is quite similar and, as material behaviour is supposed to be strongly linked to the microstructure of the tissue, porcine subcutaneous adipose tissue seems to be an acceptable model for human tissue.…”

Section: Discussionmentioning

confidence: 99%

“…The material behaviour of adipose tissue has been investigated in several studies under different loading conditions. Compressive behaviour was analysed using setups for uniaxial confined or unconfined compression or indentation testing for porcine and ovine subcutaneous adipose tissue, human abdominal tissue, human breast tissue, the human calcaneal fat pad and human plantar soft tissue [29][30][31][32][33][34][35][36][37][38][39]. Results show that adipose tissue behaves non-linear, exhibiting a J-shaped stress-strain response, typical for hyperelastic materials [27,33,36,38].…”

Section: Introductionmentioning

confidence: 99%

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Experimental characterisation of porcine subcutaneous adipose tissue under blunt impact up to irreversible deformation

et al. 2021

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A deeper understanding of the mechanical characteristics of adipose tissue under large deformation is important for the analysis of blunt force trauma, as adipose tissue alters the stresses and strains that are transferred to subjacent tissues. Hence, results from drop tower tests of subcutaneous adipose tissue are presented (i) to characterise adipose tissue behaviour up to irreversible deformation, (ii) to relate this to the microstructural configuration, (iii) to quantify this deformation and (iv) to provide an analytical basis for computational modelling of adipose tissue under blunt impact. The drop tower experiments are performed exemplarily on porcine subcutaneous adipose tissue specimens for three different impact velocities and two impactor geometries. An approach based on photogrammetry is used to derive 3D representations of the deformation patterns directly after the impact. Median values for maximum impactor acceleration for tests with a flat cylindrical impactor geometry at impact velocities of 886 mm/s, 1253 mm/s and 2426 mm/s amount to 61.1 g, 121.6 g and 264.2 g, respectively, whereas thickness reduction of the specimens after impact amount to 16.7%, 30.5% and 39.3%, respectively. The according values for tests with a spherically shaped impactor at an impact velocity of 1253 mm/s are 184.2 g and 78.7%. Based on these results, it is hypothesised that, in the initial phase of a blunt impact, adipose tissue behaviour is mainly governed by the behaviour of the lipid inside the adipocytes, whereas for further loading, contribution of the extracellular collagen fibre network becomes more dominant.

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Comparison of porcine and human adipose tissue loading responses under dynamic compression and shear: A pilot study

Cited by 21 publications

References 26 publications

A review of bioengineering techniques applied to breast tissue: Mechanical properties, tissue engineering and finite element analysis

A review of bioengineering techniques applied to breast tissue: Mechanical properties, tissue engineering and finite element analysis

Reduced fibrous capsule elastic fibers from biologic ECM-enveloped CIEDs in minipigs, supported with a novel compression mechanics model

Experimental characterisation of porcine subcutaneous adipose tissue under blunt impact up to irreversible deformation

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