volume 69, issue 3, P147-156 2000
DOI: 10.5025/hansen.69.147
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Abstract: Mycobacterium leprae, the etiologic agent of leprosy remains one of the few pathogens that can not be cultivated in vitro. The diagnosis of leprosy is still based upon principles used a century ago: clini cal examination of the patient lesions, demonstra tion of acid-fast bacilli (AFB) in slit-skin smears, and histopathology. Leprosy is most easily diagnosed when Mycobacterium leprae are demonstrable in dis eased tissues, but this is often difficult in the inde terminate and in the tuberculoid types of leprosy…

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