Comparison of percentage excess weight loss and body composition after Roux-en-Y gastric bypass versus sleeve gastrectomy: A prospective study

Abstract

Background: The aim of the present study was to evaluate the efficacy of Roux-en-Y gastric bypass (RYGB) vs. sleeve gastrectomy (SG) on glycemic control and blood lipid profile at preoperative (baseline), three and six months after surgery. Methods: In a prospective non-randomized design, 32 participants, SG (n = 11) and RYGB (n = 21) completed the study. Results: Results showed that fasting blood glucose (FBG) and Hemoglobin A1C (HbA1C) were significantly reduced from 113.55±30.18 mg/dL at baseline to 93.6±14.81 mg/dL at three months post operation following SG (p = 0.006). In addition, HbA1C decreased significantly in both groups at baseline, three- and six-months post operation (SG 6.41± 0.96, 5.4±0.36 and 5.28±0.57 % (p = 0.022) and RYGB 5.91± 0.94, 5.11± 0.57 and 4.96± 0.55% (p<0.001) respectively). Levels of high-density lipoprotein (HDL) were restored significantly in both groups at 6 months compared to three months post-surgery (SG 41.2± 9.99, 38.67±4.85 and 45.36± 6.22 (p = 0.023) and RYGB 42.67± 9.97, 36.58± 6.06 and 43.03± 6.66 (p =0.003) respectively), whereas there is no significant different in low-density lipoprotein and total cholesterol. Conclusions: Both bariatric surgery (SG and RYGB) improved glycemic control and blood lipid profile. Trial registration: The trial is registered with Thai Clinical Trials Registry (TCTR20210429004) April 29, 2021.