2011
DOI: 10.4238/2011.december.8.4
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Comparison of oxidative stress and the frequency of polymorphisms in the HFE gene between hemoglobin S trait blood donors and sickle cell disease patients

Abstract: ABSTRACT. It is well documented that Hb S and iron affect blood cells, and trigger oxidative processes and generation of free radicals with potential for lipid peroxidation. We evaluated the frequency of polymorphisms in the HFE gene in Hb AS blood donors and how these polymorphisms influenced lipid peroxidation and antioxidant capacity. Blood samples were collected from 211 Hb AS blood donors, 119 Hb AA blood donors as a control group, and 28 sickle cell disease patients (Hb SS). The H63D allele was found at … Show more

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Cited by 7 publications
(2 citation statements)
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“…However, the frequency of the H63D allele (3.05%) in the control group was lower than that reported for Brazilian blood donors: 2.1% and 13.4% for C282Y and H63D, respectively. 27 28 …”
Section: Discussionmentioning
confidence: 99%
“…However, the frequency of the H63D allele (3.05%) in the control group was lower than that reported for Brazilian blood donors: 2.1% and 13.4% for C282Y and H63D, respectively. 27 28 …”
Section: Discussionmentioning
confidence: 99%
“…Remarkably, the lipid peroxidation level of FAC-LIP is an important indicator of whether it is toxic or not. Obviously, some related studies including our previous research (Vianabaracioli et al, 2011;Yuan et al, 2013) confirmed that the liposomal encapsulation was not obvious toxic, from the measurement of the malondialdehyde (MDA) level and superoxide dismutase (SOD) activity. However, the mechanism of oral bioavailability enhancement of FAC-LIP will be further elucidated.…”
Section: Oral Pharmacokinetics and Bioavailability Studymentioning
confidence: 93%