Comparison of morphine sulphate and codeine phosphate in children undergoing adenotonsillectomy

Abstract

We undertook a double-blind study to evaluate equianalgesic doses of intramuscular morphine sulphate (0.15 mg.kg-1) and codeine phosphate (1.5 mg.kg-1) in 40 healthy children undergoing adenotonsillectomy. There were no significant differences in pain scores, analgesic requirements or sedation scores between the two groups over the following 24 h. More children vomited in the morphine group (60%) than the codeine group (30%) between one and six h after the procedure (P < 0.05). Codeine phosphate is associated with less postoperative vomiting than morphine sulphate while providing comparable postoperative analgesia for adenotonsillectomy.

An evaluation of pain and postoperative nausea and vomiting following the introduction of guidelines for tonsillectomy

“…The incidence of vomiting after introduction of our guidelines was 5% which was similar to our PONV rate beforehand and compares favorably with other studies evaluating NSAIDs (2,4,7). The incidence of PONV associated with intraoperative morphine ranges from 50 to 80% (11–13,20) although this can be reduced by ondansetron (13). However, antiemetic prophylaxis is not without risk.…”

Comparison of Analgesic Effect between Gabapentin and Diclofenac on Post-Operative Pain in Patients Undergoing Tonsillectomy

“…Several factors are used to treat postoperative pain. Opioids are the most common medications for pain relief (2). However, they can put the patient at risk by high incidence of nausea and vomiting (3), leading to causing respiratory depression (4).…”

Comparison of Codeine Phosphate and Morphine Sulphate in Infants Undergoing Cleft Palate Repair

“…Although codeine and morphine have been compared in older age groups (Semple et al, 1999;Williams et al, 2002), their use following cleft palate surgery in infants is not well supported by the literature. Unpublished data suggest that most anesthetists see the need to provide some opioid analgesia for cleft palate repair, with roughly half opting for codeine and half morphine (Ruschen and Sury, 2003).…”