Comparison of liver stiffness measurement with MRE and liver and spleen volumetry for prediction of disease severity and hepatic decompensation in patients with primary sclerosing cholangitis

İdilman, İlkay S.; Low, Hsien Min; Bakhshi, Zeinab; Eaton, John E.; Venkatesh, Sudhakar K.

doi:10.1007/s00261-019-02387-4

Cited by 9 publications

(5 citation statements)

References 22 publications

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“…In alignment with our study, no correlation between stiffness and MRS was found. However, published results on the relationship of stiffness and MRS are mixed 18 – 20 , 38 , 39 . For instance, Idilman et al observed a positive correlation between hepatic stiffness and MRS ( R = 0.646, P < 0.0001) in a large cohort of 266 patients 39 .…”

Section: Discussionmentioning

confidence: 99%

“…However, published results on the relationship of stiffness and MRS are mixed 18 – 20 , 38 , 39 . For instance, Idilman et al observed a positive correlation between hepatic stiffness and MRS ( R = 0.646, P < 0.0001) in a large cohort of 266 patients 39 . Moreover, Tafur et al found that stiffness had a superior discriminatory ability than morphological intrahepatic stricture severity to distinguish MRS-based risk groups (AUC of 0.779 and 0.718; respectively) 38 .…”

Section: Discussionmentioning

confidence: 99%

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Spatial heterogeneity of hepatic fibrosis in primary sclerosing cholangitis vs. viral hepatitis assessed by MR elastography

Reiter

Shahryari

Tzschätzsch

et al. 2021

Sci Rep

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Spatial heterogeneity of hepatic fibrosis in primary sclerosing cholangitis (PSC) in comparison to viral hepatitis was assessed as a potential new biomarker using MR elastography (MRE). In this proof-of-concept study, we hypothesized a rather increased heterogeneity in PSC and a rather homogeneous distribution in viral hepatitis. Forty-six consecutive subjects (PSC: n = 20, viral hepatitis: n = 26) were prospectively enrolled between July 2014 and April 2017. Subjects underwent multifrequency MRE (1.5 T) using drive frequencies of 35–60 Hz and generating shear-wave speed (SWS in m/s) maps as a surrogate of stiffness. The coefficient of variation (CV in %) was determined to quantify fibrosis heterogeneity. Mean SWS and CV were 1.70 m/s and 21% for PSC, and 1.84 m/s and 18% for viral hepatitis. Fibrosis heterogeneity was significantly increased for PSC (P = 0.04) while no difference was found for SWS of PSC and viral hepatitis (P = 0.17). Global hepatic stiffness was similar in PSC and viral hepatitis groups, but spatial heterogeneity may reveal spatial patterns of stiffness changes towards enhanced biophysics-based diagnosis by MRI.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Spatial heterogeneity of hepatic fibrosis in primary sclerosing cholangitis vs. viral hepatitis assessed by MR elastography

Reiter

Shahryari

Tzschätzsch

et al. 2021

Sci Rep

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“…Idilman et al assessed patients who underwent liver MRI with MRE. Volumetric measurements showed moderate accuracy in predicting the high Mayo risk score group but were inferior to liver stiffness using MRE [ 79 ]. Khoshpouri analysed PSC patients using CT and MRI to obtain volumetric measurements.…”

Section: Methodsmentioning

confidence: 99%

The impact of hepatic and splenic volumetric assessment in imaging for chronic liver disease: a narrative review

Kutaiba,

Chung,

Goodwin

et al. 2024

Insights Imaging

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Chronic liver disease is responsible for significant morbidity and mortality worldwide. Abdominal computed tomography (CT) and magnetic resonance imaging (MRI) can fully visualise the liver and adjacent structures in the upper abdomen providing a reproducible assessment of the liver and biliary system and can detect features of portal hypertension. Subjective interpretation of CT and MRI in the assessment of liver parenchyma for early and advanced stages of fibrosis (pre-cirrhosis), as well as severity of portal hypertension, is limited. Quantitative and reproducible measurements of hepatic and splenic volumes have been shown to correlate with fibrosis staging, clinical outcomes, and mortality. In this review, we will explore the role of volumetric measurements in relation to diagnosis, assessment of severity and prediction of outcomes in chronic liver disease patients. We conclude that volumetric analysis of the liver and spleen can provide important information in such patients, has the potential to stratify patients’ stage of hepatic fibrosis and disease severity, and can provide critical prognostic information. Critical relevance statement This review highlights the role of volumetric measurements of the liver and spleen using CT and MRI in relation to diagnosis, assessment of severity, and prediction of outcomes in chronic liver disease patients. Key Points Volumetry of the liver and spleen using CT and MRI correlates with hepatic fibrosis stages and cirrhosis. Volumetric measurements correlate with chronic liver disease outcomes. Fully automated methods for volumetry are required for implementation into routine clinical practice. Graphical Abstract

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“…62 In addition to staging fibrosis, MRE might be useful for risk stratification. Some studies have shown that baseline hepatic stiffness predicts future risk of cirrhosis development in NAFLD, 63 clinical decompensation in cirrhotic patients 64 or HCC development and recurrence. 65 The utility and cost-effectiveness of applying baseline MRE for these purposes have not yet been established, however.…”

Section: Clinical and Research Implementationmentioning

confidence: 99%

Quantitative magnetic resonance imaging for chronic liver disease

Cunha

Navin

Fowler

et al. 2021

The British Journal of Radiology

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Chronic liver disease (CLD) has rapidly increased in prevalence over the past two decades, resulting in significant morbidity and mortality worldwide. Historically, the clinical gold standard for diagnosis, assessment of severity, and longitudinal monitoring of CLD has been liver biopsy with histological analysis, but this approach has limitations that may make it suboptimal for clinical and research settings. Magnetic resonance (MR)-based biomarkers can overcome the limitations by allowing accurate, precise, and quantitative assessment of key components of CLD without the risk of invasive procedures. This review briefly describes the limitations associated with liver biopsy and the need for non-invasive biomarkers. It then discusses the current state-of-the-art for MRI-based biomarkers of liver iron, fat, and fibrosis, and inflammation.

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Comparison of liver stiffness measurement with MRE and liver and spleen volumetry for prediction of disease severity and hepatic decompensation in patients with primary sclerosing cholangitis

Cited by 9 publications

References 22 publications

Spatial heterogeneity of hepatic fibrosis in primary sclerosing cholangitis vs. viral hepatitis assessed by MR elastography

Spatial heterogeneity of hepatic fibrosis in primary sclerosing cholangitis vs. viral hepatitis assessed by MR elastography

The impact of hepatic and splenic volumetric assessment in imaging for chronic liver disease: a narrative review

Quantitative magnetic resonance imaging for chronic liver disease

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