Comparison of Liquid-Based Cytology and Conventional Papanicolaou Smear for Cervical Cancer Screening: An Experience From Pakistan

Hashmi, Atif Ali; Naz, Samreen; Ahmed, Omer; Yaqeen, Syed Rafay; Irfan, Muhammad; Asif, Muhammad; Kamal, Anwar; Faridi, Naveen

doi:10.7759/cureus.12293

Cited by 16 publications

(18 citation statements)

References 9 publications

(9 reference statements)

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“…As a new cytological smear method, the cervical cells prepared by liquid-based cytology have a clear structure and can improve the detection sensitivity. Some related studies also show that it has a good diagnostic effect [ 3 ]. However, some scholars have proposed that cytology alone cannot completely screen cervical lesions.…”

Section: Introductionmentioning

confidence: 99%

[Retracted] Investigation of the Clinical Application Value of HR‐HPV DNA Combined with Liquid Based Cytology in Colposcopy of Cervical Cancer

Zhou

2022

Contrast Media & Molecular Imaging

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In order to investigate the clinical application value of HR-HPV DNA combined with liquid-based cytology in colposcopy of cervical cancer, a retrospective analysis is performed on 428 patients who underwent a cervical pathological examination in our hospital from May 2020 to December 2021. The pathological biopsy results are used as the gold standard to determine whether cervical lesions occurred in patients, and patients with positive gold standard results are included in the study group. The positive rates of liquid-based cytology and HR-HPV DNA are observed and recorded, and the patients with negative gold standard results are used as the control group. The positive rate of HR-HPV DNA and liquid-based cytology will increase with the aggravation of pathological results. The ROC curve shows that HR-HPV DNA combined with liquid-based cytology has high diagnostic efficiency in colposcopy of cervical lesions. It is clearly evident that both liquid-based cytology and HR-HPV DNA tests have certain advantages in the screening of cervical lesions, and the combined detection can further improve the screening value of cervical lesions.

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Section: Introductionmentioning

confidence: 99%

[Retracted] Investigation of the Clinical Application Value of HR‐HPV DNA Combined with Liquid Based Cytology in Colposcopy of Cervical Cancer

Zhou

2022

Contrast Media & Molecular Imaging

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“…The previous study results showed that the LBC performed better than the conventional method of cytology to detect recurrence of squamous‐cell carcinoma. Its sensitivity, specificity as well as accuracy were much higher than the conventional method 20,21 . Since the cytology sample with maximum cell count and better storage conditions will be a more powerful tool for further evaluations.…”

Section: Discussionmentioning

confidence: 94%

The comparative evaluation of CK17 expression in histologic and cytological sections of oral squamous‐cell carcinoma using immunohistochemistry

Razavi

Torabinia

Sarrafpour

et al. 2023

Diagnostic Cytopathology

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Backgroud Squamous‐cell carcinoma of the mouth accounts for 90% of all oral cancers and despite advances in treatment methods, its 5‐year survival rate is reported to be about 68%. This is due to the late diagnosis of the disease and its resistance to radiotherapy and chemotherapy treatments. One of the methods for diagnosing oral lesions is exfoliative cytology, which is a noninvasive method and can be easily carried out in a dental office. Aim The purpose of this study is to find a method that in addition to being fast, accurate and less aggressive has high value and a good degree of accuracy for diagnosis of oral squamous‐cell carcinoma. Materials and Methods In this descriptive‐analytical study, 14 patients who were diagnosed with oral squamous‐cell carcinoma and 14 specimens from exfoliative cytology of the same tissue before surgery were examined. Immunohistochemically stained specimens were examined by two pathologists simultaneously. Next, five nonoverlapping sections with magnification (×400) and the number of cells stained with the cytokeratin marker 17 are counted and the average percentage of each slide is determined. One‐sample t‐test is used to analyze the data and significance level in tests is considered 0.05. Results In examining the diagnostic value of cytology, we concluded that out of 280 affected cells, 211 cells were stained. Therefore, the sensitivity of cytology in the diagnosis of squamous‐cell carcinoma of the mouth is 75.4%. In other words, cytology correctly identifies 75.4% of affected cells as affected. Also, the positive predictive value of cytology was 100%.

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“…A study published by Phaliwong et al in 2018 on 28,564 cases showed that the percentage of unsatisfactory Pap smears was significantly higher than LBC (52.3% vs. 40.5%) [ 36 ]. The opinion suggesting the need for the extensive use of LBC in CC screening instead of a Pap smear is very well established in the literature [ 37 , 38 , 39 , 40 ]. In contrast, there is no evidence to explain that LBC differs from Pap smear in their accuracy in detecting CIN2+ lesions [ 41 ].…”

Section: Review Resultsmentioning

confidence: 99%

Cervical Cancer Prophylaxis—State-of-the-Art and Perspectives

Poniewierza¹,

Panek

2022

Healthcare

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Background: Each year 604,127 new cases of cervical cancer (CC) are diagnosed, and 341,831 individuals die from the disease. It is the fourth most common cancer among women and the fourth most common cause of death from female cancers worldwide. The pathogenesis of CC is associated with human papillomavirus (HPV) infections and consists of several steps involving cell proliferation outside the human body’s control mechanisms. Strategies to prevent CC are based on screening and vaccination. Scope of the Review: The aim of this paper was to collect and analyze the available literature on the issue of CC prevention and the impact of the COVID-19 pandemic on its implementation. For this purpose, PubMed and Google Scholar databases were searched using keywords, such as “cervical cancer”; “HPV”; “prevention”; “prophylaxis”; “vaccination”; “screening” and “COVID-19” in different variations. Only articles published since 2018 were included in the study. Conclusions: Selected European countries have different CC prevention programs funded by national budgets. This translates into observed differences in the risk of death from CC (age-standardized rate Malta = 1.1, Poland = 5.9). COVID-19 pandemic due to disruption of CC screening may exacerbate these differences in the future. To improve the situation, new screening methods, such as p16/Ki67, HPV self-testing, and the use of artificial intelligence in colposcopic assessment, should be disseminated, as well as free HPV vaccination programs implemented in all countries. The search for new solutions is not without significance and entails ultra-sensitive screening tests for risk groups (mRNA E6/E7, SOX1/SOX14), HPV vaccines with shorter dosing schedules, and new therapeutic pathways using nanotheranostics.

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Comparison of Liquid-Based Cytology and Conventional Papanicolaou Smear for Cervical Cancer Screening: An Experience From Pakistan

Cited by 16 publications

References 9 publications

[Retracted] Investigation of the Clinical Application Value of HR‐HPV DNA Combined with Liquid Based Cytology in Colposcopy of Cervical Cancer

[Retracted] Investigation of the Clinical Application Value of HR‐HPV DNA Combined with Liquid Based Cytology in Colposcopy of Cervical Cancer

The comparative evaluation of CK17 expression in histologic and cytological sections of oral squamous‐cell carcinoma using immunohistochemistry

Cervical Cancer Prophylaxis—State-of-the-Art and Perspectives

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