Comparison of lipid profiles in normal and hypertensive pregnant women

Ic, Evrüke; Demir, Süleyman Cansun; If, Urünsak; Ozgunen, FT; Kadayifçi, Oktay

doi:10.5144/0256-4947.2004.382

Cited by 13 publications

(17 citation statements)

References 17 publications

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“…During pregnancy, serum lipoproteins except HDL-C increase considerably 17 and are two-to threetimes higher in PIH. Worldwide, various studies 5,[18][19][20][21][22][23][24] have reported elevated lipid levels in PIH subjects similar to our observations. In the present study, TC was significantly increased (p <0.01) in PIH subjects compared to control subjects consistent with other studies.…”

Section: Discussionsupporting

confidence: 82%

“…30,31 In our study, HDL-C was significantly lower (p <0.001) in PIH patients as compared to the control subjects as was observed in other studies. 19,[21][22][23][24][25][26]28,29 A similar difference was not evident in one study, 20 while other researchers 32,33 observed higher HDL-C level in PIH women.…”

Section: Discussionmentioning

confidence: 59%

“…[19][20][21][22][23][24][25][26]28,29 In contrast, recent studies 24,32 showed no significant difference of LDL-C. The significant lower levels of LDL-C was noted in hypertensive pateints compared to the normotensive.…”

Section: Discussionmentioning

confidence: 86%

“…In the present study, TC was significantly increased (p <0.01) in PIH subjects compared to control subjects consistent with other studies. [20][21][22][23][24][25][26][27] But no significant changes in TC could be observed by some other workers. 5,19,24,28,29 Finnish and Peruvian PIH subjects had higher mean TG and lower HDL-C than the control group.…”

Section: Discussionmentioning

confidence: 99%

“…Similar observations were reported by other researchers. 19,20,[22][23][24][25][26]29 No significant correlation with triglycerides was observed in another study. 33 The principle modulator of the hypertriglyceridaemia is oestrogen as pregnancy is linked with hyperoestrogenaemia.…”

Section: Discussionmentioning

confidence: 99%

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Role of dyslipidaemia and lipid peroxidation in pregnancy induced hypertension

Saxena¹,

Thimmaraju²,

Srivastava³

et al. 2015

J Clin Sci Res

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Background: Pregnancy induced hypertension (PIH) contributes greatly to maternal morbidity and mortality. Altered lipid profile and increased lipid peroxidation activate endothelial dysfunction and atherothrombosis leading to PIH. Therefore, estimation of lipid profile with serum malondialdehyde (MDA) in pregnancy may be helpful in predicting the development of PIH and further progression. Material and methods:In this prospective case-control study, serum lipid profile and MDA were estimated in 70 PIH subjects with gestational hypertension, pre-eclampsia, eclampsia; and 70 normotensive pregnant women aged 18 -40 years, with gestational age of over 20 weeks.Results: A statistically significant higher serum total cholesterol, very low density lipoprotein cholesterol (VLDL-C), low density lipoprotein cholesterol (LDL-C), triglycerides (TG), TC/HDL-C, LDL-C/HDL-C and MDA, and a significantly lower HDL-C was noted in PIH subjects as compared to control subjects. When compared with the severity of PIH, all the lipoproteins (except HDL-C) along with MDA were found to be higher in women with eclampsia when compared with gestational hypertension, pre-eclampsia and normotensive pregnant women. Conclusions:An abnormal lipid metabolism along with oxidative stress may add to the promotion of vascular dysfunction leading to PIH. Lipoproteins and MDA alter significantly in eclampsia. Therefore, during pregnancy, early diagnosis and management of dyslipidaemia may prevent lipid peroxidation and progression of PIH thereby preventing obstetric complications.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Role of dyslipidaemia and lipid peroxidation in pregnancy induced hypertension

Saxena¹,

Thimmaraju²,

Srivastava³

et al. 2015

J Clin Sci Res

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Placental secretion of apolipoprotein A1 and E: the anti-atherogenic impact of the placenta

Melhem

Kallol

Huang

et al. 2019

Sci Rep

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High levels of atherogenic lipids in pregnancy are associated with health complications for the mother, the fetus and the newborn. As endocrine secretory tissue, the human placenta releases apolipoproteins (apos), particularly apoA1 and apoE. However, the magnitude and the directionality of the apo secretions remain unknown. We aimed to 1) determine the amount and orientation (apical-maternal versus basal-fetal) of placentally secreted apoA1 and apoE using human perfused placenta and primary trophoblast cell (PTC) culture, 2) compare apoA1 and apoE secretions of PTC with that of hepatocytes and 3) associate the obtained results with human blood levels by determining apoA1 and apoE concentrations in maternal and fetal serum samples. In perfused placenta and serum samples, apoA1 and apoE concentrations were significantly higher at the maternal compared to the fetal side. For apoE a similar trend was found in PTC. For apoA1, the secretion to the apical side declined over time while release to the basal side was stable resulting in significantly different apoA1 concentrations between both sides. Unexpectedly, PTC secreted significantly higher amounts of apoA1 and apoE compared to hepatocytes. Our data indicate that the placenta may play an important role in maternal and fetal cholesterol homeostasis via secretion of anti-atherogenic apos.

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A Tertiary Care Centre Based Study on Serum Lipid Levels in Healthy Non-Pregnant Women, Normal Pregnancy and in Preeclampsia

S¹,

Maliekkal²,

Geetha³

et al. 2018

jemds

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BACKGROUND Preeclampsia is more prevalent in the first pregnancy and is associated with very high maternal and foetal morbidity and mortality. Although, the exact cause of preeclampsia is still unknown, the basic pathology lies in the endothelial cell dysfunction and intense vasospasm. Dyslipidaemia is believed to play a key role in altering the microenvironment around endothelium. So, the objective is to study the serum lipid levels in healthy non-pregnant women, normal pregnancy and in preeclampsia. MATERIALS AND METHODS Fasting serum lipid levels were estimated in 40 healthy non-pregnant women (Group-1), 40 normotensive primigravida (Group-2) and in 40 preeclamptic primigravida in their third trimester (Group-3). Serum lipid levels were estimated using fully automated analyser. Data was analysed using SPSS Version 18 software. P value < 0.05 was considered as statistically significant. RESULTS Compared with normal pregnancy, in preeclampsia, the level of serum total cholesterol, triglycerides, VLDL and LDL were significantly increased and HDL was decreased significantly. In normal pregnant women, serum total cholesterol, triglycerides, HDL, VLDL and LDL levels were significantly high compared to healthy non-pregnant women. CONCLUSION Dyslipidaemia in pregnancy may be associated with increased risk of developing preeclampsia. Screening of the above parameters may help in developing strategies for prevention and better management of preeclampsia.

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Comparison of lipid profiles in normal and hypertensive pregnant women

Cited by 13 publications

References 17 publications

Role of dyslipidaemia and lipid peroxidation in pregnancy induced hypertension

Role of dyslipidaemia and lipid peroxidation in pregnancy induced hypertension

Placental secretion of apolipoprotein A1 and E: the anti-atherogenic impact of the placenta

A Tertiary Care Centre Based Study on Serum Lipid Levels in Healthy Non-Pregnant Women, Normal Pregnancy and in Preeclampsia

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