Comparison of lifelong and late life exercise on oxidative stress in the cerebellum

Cui, Li; Hofer, Tim; Rani, Asha; Leeuwenburgh, Christiaan; Foster, Thomas C.

doi:10.1016/j.neurobiolaging.2007.09.005

Cited by 63 publications

(47 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Cognitive and voluntary physical exercise has been shown to lower peripheral oxidative stress in both humans and animals (Gomez-Cabrera et al, 2008) and cerebral oxidative damage in aging animals (Cui et al, 2009;Opii et al, 2008), thereby revealing neuro-/cardioprotective abilities (Cechetti et al, 2008;Powers et al, 1994). This work demonstrates that 2VO hypoperfusion causes an increase in free radical content and basal TBARS in hippocampus, and that these measurements return to normal levels with exposure to an enriched environment ( Fig.…”

Section: Discussionmentioning

confidence: 54%

Environmental enrichment prevents behavioral deficits and oxidative stress caused by chronic cerebral hypoperfusion in the rat

et al. 2012

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 54%

Environmental enrichment prevents behavioral deficits and oxidative stress caused by chronic cerebral hypoperfusion in the rat

et al. 2012

View full text Add to dashboard Cite

show abstract

“…Sections (10- SOD activity was measured using the HT SOD assay kit (Trevigen, Inc.) and protein carbonyls were measured using a commercial ELISA (Zentech PC Test, Protein Carbonyl Enzyme Immuno-Assay Kit; Biocell Corp.) according to the manufacturer's instructions. 8-oxo-7,8-dihydro-2-deoxyguanosine (8-oxodGuo) levels were determined according to our previously published methods (12).…”

Section: Immunohistochemistrymentioning

confidence: 99%

Influence of Viral Vector–Mediated Delivery of Superoxide Dismutase and Catalase to the Hippocampus on Spatial Learning and Memory During Aging

Lee

Kumar

Rani

et al. 2012

Antioxidants & Redox Signaling

Self Cite

View full text Add to dashboard Cite

Aims: Studies employing transgenic mice indicate that overexpression of superoxide dismutase 1 (SOD1) improves memory during aging. It is unclear whether the improvement is due to a lifetime of overexpression, decreasing the accumulation of oxidized molecules, or if increasing antioxidant enzymes in older animals could reduce oxidative damage and improve cognitive function. We used adeno-associated virus to deliver antioxidant enzymes (SOD1, SOD2, catalase [CAT], and SOD1+CAT) to the hippocampus of young (4 months) and aged (19 months) F344/BN F1 male rats and examined memory-related behavioral performance 1 month and 4 months postinjection. Results: Overexpression of antioxidant enzymes reduced oxidative damage; however, memory function was not related to the level of oxidative damage. Increased expression of SOD1, initiated in advanced age, impaired learning. Increased expression of SOD1+CAT provided protection from impairments associated with overexpression of SOD1 alone and appears to guard against cognitive impairments in advanced age. Innovation: Viral vector gene delivery provides a novel approach to test the hypothesis that increased expression of antioxidant enzymes, specifically in hippocampal neurons, will provide protection from age-related cognitive decline. Further, expression of multiple vectors permits more detailed investigation of mechanistic pathways. Conclusion: Oxidative stress is a likely component of aging; however, it is unclear whether increased production of reactive oxygen species or the accumulation of oxidative damage is the primary cause of functional decline. The results provide support for the idea that altered redox-sensitive signaling rather than the accumulation of damage may be of greater significance in the emergence of age-related learning and memory deficits. Antioxid. Redox Signal. 16,[339][340][341][342][343][344][345][346][347][348][349][350]

show abstract

“…Purkinje cells of the cerebellum indicates development of DNA damage that begins at middle age and lasts for whole life. Even more important is that the degeneration and degree in loss of function are managed by lifelong exercise (Cui, Hofer, Rani, Leeuwenburgh, & Foster, 2009). In this context, this study was designed to examine the acute effect on oxidative stress parameters in the cerebellum tissue of different swimming exercises.…”

Section: Discussionmentioning

confidence: 99%

Effects of Different-Term Acute Swimming Exercises on Oxidative Stress Parameters in Rat Cerebellum Tissue

Akyüz¹

2016

UCER-B

View full text Add to dashboard Cite

Background: Regular physical activity may prevent the onset of a large range of pathological conditions, from heart diseases to mental disorders (depression, anxiety, panic disorder, social phobia, etc.), ischemia, and neurodegenerative diseases. Although beneficial effects of exercise are not known exactly for molecular mechanisms, several hypotheses have been proposed about this research. The purpose of this study is to examine the acute effects of oxidative stress parameters on the cerebellum tissue of the different swimming exercises. Methods:Telve week-old male Albino Wistar rats (n = 32) were used in this study. Rats were divided randomly into four groups: control, short-term exercise (15 mins.), moderate-term exercise (30 mins.), and long-term exercise (60 mins.) group. Glass tank containing water for swimming exercise (L x W x H, 100 x 50 x 50 cm) was used as pool. Results:The differences among superoxide dysmutase (SOD), glutathione (GSH), and malondialdehyde (MDA) were studied. When the difference were examined between SOD levels, short-term and moderate-term exercise groups were statistically significant different from other groups (p < 0.05). When GSH levels were examined, moderate-term and long-term groups were statistical different than other groups (p < 0.05). When MDA levels were examined, all exercise groups being compared with the control group had statistically significant differences (p < 0.05).Conclusions: SOD, GSH, and MDA levels were found to be higher in the moderate-term exercising rat's cerebellum tissue compared to rats that other groups.

show abstract

Comparison of lifelong and late life exercise on oxidative stress in the cerebellum

Cited by 63 publications

References 46 publications

Environmental enrichment prevents behavioral deficits and oxidative stress caused by chronic cerebral hypoperfusion in the rat

Environmental enrichment prevents behavioral deficits and oxidative stress caused by chronic cerebral hypoperfusion in the rat

Influence of Viral Vector–Mediated Delivery of Superoxide Dismutase and Catalase to the Hippocampus on Spatial Learning and Memory During Aging

Effects of Different-Term Acute Swimming Exercises on Oxidative Stress Parameters in Rat Cerebellum Tissue

Contact Info

Product

Resources

About