Comparison of isradipine and nifedipine in chronic stable angina

Handler, Clive; Rosenthal, Éric; Tsagadopoulos, D.; Najm, Y. C.

doi:10.1016/0167-5273(88)90026-5

Cited by 9 publications

(3 citation statements)

References 19 publications

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“…Maximum exercise duration and ST segment depression also showed improvement. Other small studies have compared isradipine with nifedipine (46,47) or long-acting nitrates (44). Symptomatic improvements were very similar with all drugs, although in one instance isradipine was significantly superior to nifedipine in prolonging the time before the onset of angina, and another group suggested that isradipine may more effectively reduce myocardial oxygen consumption during exercise.…”

Section: Stable Anginamentioning

confidence: 99%

Isradipine

Schachter¹

1991

J Clin Pharm Ther

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Isradipine is a potent dihydropyridine calcium channel blocker. It is highly selective for vascular smooth muscle, with very few negative inotropic or chronotropic effects. It may have minor depressant effects on the sinoatrial node, hence reducing the incidence of reflex tachycardia. The drug is extensively metabolized in the liver, with several pharmacologically inactive metabolites. As the elimination half-life is about 9 h the drug is usually given twice daily, but a once-daily modified release form is under investigation. Isradipine is effective monotherapy in essential hypertension, and has been successfully combined with pindolol and captopril. On the basis of more limited evidence it also appears to be beneficial in stable angina and in congestive cardiac failure. A trial is also under way to assess its antiatherogenic properties. Adverse effects are those predicted for a vasodilator calcium antagonist, and may be less frequent than for equivalent doses of nifedipine. This needs to be confirmed by more extensive clinical experience. Overall, isradipine can be considered favourably in essential hypertensives where a calcium channel blocker is indicated, particularly if it is desirable to avoid myocardial depression or to minimize reflex tachycardia. Its role in other cardiovascular disease awaits further evaluation.

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Section: Stable Anginamentioning

confidence: 99%

Isradipine

Schachter¹

1991

J Clin Pharm Ther

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“…Isradipine, a new dihydropyridine calcium antagonist, has been shown to be effective in the treatment of patients with hypertension or angina pectoris [2][3][4]. A smaller negative inotropic effect and less reflex tachycardia compared to nifedipine make isradipine a promising compound in the treatment of patients with coronary artery disease and congestive heart failure [5].…”

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confidence: 99%

Renal effects of the new calcium channel blocking drug isradipine

Krämer

Häussler

Ress

et al. 1990

Eur J Clin Pharmacol

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Summary. The acute effect of a single oral dose of isradipine 5 mg on blood pressure, renal haemodynamics, electrolyte excretion and plasma renin activity was studied in 10 healthy males.Isradipine did not produce a significant change in systolic or diastolic blood pressure, and glomerular filtration rate, renal plasma flow, renal vascular resistance, and urinary albumin excretion remained constant. There was a marked natriuretic and diuretic effect about 1-3 h after isradipine. Plasma renin activity showed a slight, insignificant increase i h after dosing. Uric acid clearance and 132-microglobulin excretion showed no significant changes, despite an increase in sodium clearance, suggesting an additional mechanism of action other than the proximal tubular natriuretic effect of isradipine in normotensive volunteers.

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“…A partir da década de 1980 houve maior interesse dos pesquisadores em estudar o comportamento destas drogas nas doenças cardiovasculares, comparando-as com outras drogas, comprovando sua eficácia e tolerabilidade pelo organismo, além de motivar o estudo em campos variados das pesquisas biológicas (MOSER, 1987;COLLUCI, 1987;HANDLER et al, 1988, DAHLOF & SWEDEN, 1989. em torno de seis horas, mas aumenta com a administração prolongada em crianças e pessoas idosas, sendo eliminado pela urina.…”

Section: -Bloqueadores Dos Canais De Cálcio E Verapamilunclassified

Efeitos do Verapamil (Dilacoron), bloqueador dos canais de calcio, na regenaração do figado de ratos apos hepatectomia parcial

Goulart¹,

Filho²

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A meus pais HERNANI (in memorian) e CÉLIA, que através de exemplos de integridade e luta, me ensinaram a cumprir, sempre, o dever com retidão.Ao MÁRIO e a meus filhos, ROGÉRIO e LARA, co-autores de todos os meus sonhos, companheiros constantes na luta pelas realizacões. Por tudo que representam para mim. viii ix . Aos GRANDES MESTRES e orientadores: Prof. Dr. Thales Rocha de Mattos Filho, pelo exemplo de seriedade e competência profissional, pelos ensinamentos, orientação, amizade e confiança na realização deste trabalho. Profa. Dra. Wilma Pereira Bastos Ramos, por ensinar-me a ir mais além, superando obstáculos e aprendendo a ser cada vez melhor. Pela orientação segura, apoio e incentivo constante à minha formação científica e pelo exemplo de seriedade e competência profissional. x xi Agradecimentos À Faculdade de odontologia de Piracicaba -FOP/UNICAMP, na pessoa de seu Digníssimo Diretor Prof. DR. THALES ROCHA DE MATTOS FILHO, pela opoturna realização do curso de pós-graduação e pelo apoio institucional oferecido. Meu respeito e reconhecimeto.Aos DOCENTES do curso de pós-graduação em Farmacologia, Anestesiologia e Terapêutica da Faculdade de Odontologia de Piracicaba -FOP/UNICAMP, pela grande contribuição à minha formação científica. Muito obrigado.

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Comparison of isradipine and nifedipine in chronic stable angina

Cited by 9 publications

References 19 publications

Isradipine

Isradipine

Renal effects of the new calcium channel blocking drug isradipine

Efeitos do Verapamil (Dilacoron), bloqueador dos canais de calcio, na regenaração do figado de ratos apos hepatectomia parcial

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