Comparison of Inflammation-Based Prognostic Scores in Patients undergoing Curative Resection for Non-small Cell Lung Cancer

Abstract

BackgroundInflammation-based prognostic scores, including Glasgow prognostic score (GPS), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), prognostic nutritional index (PNI), systemic immune-inflammation index (SII) and advance lung cancer inflammation index (ALI) are reported to be associated with survival in patients with non-small cell lung cancer (NSCLC). However, at present, there are no studies that compared these scoring systems for resectable NSCLC.MethodsThree hundred forty-one NSCLC patients who underwent surgery at our institution were included. The optimal cut-off values of SII and ALI were calculated by the Cutoff Finder. The area under the receiver operating characteristics curve (AUC) was calculated to compare the predictive ability of each of the scoring systems. Univariate and multivariate analyses were performed to identify the clinicopathological variables associated with overall survival.ResultsThe optimal cut-off value of SII and ALI were 471.2 × 109/L and 37.66, respectively. All scores were significantly related to the 5-year cancer-specific survival. The ALI consistently had a higher AUC value in comparison with other inflammation-based prognostic scores. A multivariate analysis showed that GPS and ALI were independently associated with overall cancer-specific survival.ConclusionTo the best of our knowledge, this is the first study to demonstrate that GPS and ALI appear to be superior to other inflammation-based prognostic scores in patients undergoing potentially curative resection for NSCLC.

<p>Predictive Values of Preoperative Prognostic Nutritional Index and Systemic Immune-Inflammation Index for Long-Term Survival in High-Risk Non-Muscle-Invasive Bladder Cancer Patients: A Single-Centre Retrospective Study</p>

“…The prognostic significance of inflammationbased markers, including SII, has been shown in many solid tumours, most notably in prostate cancer, colorectal cancer and NSCLC. [36][37][38] The optical cut-off values of PNI and SII for predicting OS and CSS outcomes remain unclear. Jeon et al reported a PNI of 51 for renal carcinoma.…”

“…The prognostic significance of inflammation-based markers, including SII, has been shown in many solid tumours, most notably in prostate cancer, colorectal cancer and NSCLC. 36 – 38 …”

Prognostic role of the advanced lung cancer inflammation index in cancer patients: a meta-analysis

“…1. Ultimately, nine studies met our selection criteria; after excluding duplicated studies and reviewing the full texts of the manuscripts [25,[29][30][31][32][33][34][35][36], a total of 1736 cases were included. With respect to prognostic outcomes, nine studies reported OS, two studies reported progression-free survival, and one study reported disease-free survival.…”

Preoperative systemic inflammation score (SIS) is superior to neutrophil to lymphocyte ratio (NLR) as a predicting indicator in patients with esophageal squamous cell carcinoma

“…Nowadays, a superior inflammation marker, the SIS, was reported to have the value in predicting the outcomes in the solid tumors such as gastric cancer, non-small cell lung cancer, cervical carcinoma et.al [15, 17, 18]. However, the studies focused on the relationship between the SIS and the ESCC patients’ outcome were rare.…”

“…Patient with low score (both elevated Alb and LMR) had a significant survival benefit compared with the patients with high score (both decreased Alb and LMR). In another study by Masaki Tomita et.al [17], who studied 341 non-small cell lung cancer and showed that SIS was a novel independent prognostic factors in predicting the non-small cell lung cancer patients’ OS. In that study, the SIS was based on the combination the pretreatment serum C-reactive protein and Alb and showed that the patients with high SIS (C-reactive protein> 10 ng/L and Alb< 35 g/L) had adverse impact on the patients’ overall survival.…”