Comparison of Infantile Hemangiomas in Preterm and Term Infants: A Prospective Study

Garzon, María C.; Drolet, Beth A.; Baselga, Eulàlia; Chamlin, Sarah L.; Haggstrom, Anita N.; Horii, Kimberly A.; Lucky, Anne W.; Mancini, Anthony J.; Metry, Denise; Newell, Brandon; Nopper, Amy J.; Frieden, Ilona J.

doi:10.1001/archderm.144.9.1231

Cited by 55 publications

(45 citation statements)

References 6 publications

(2 reference statements)

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“…It occurs 2.2 to 4.5 times more frequently in females and in up to 20% in premature infants [1,3,[8][9][10][11][12][13]. Of 6 of our cases, 5 were girls and 4 were premature, consistent with published data [14].…”

Section: Discussionsupporting

confidence: 88%

Propranolol: useful therapeutic agent for the treatment of ulcerated infantile hemangiomas

Kim

Hogeling

Wargon

et al. 2011

Journal of Pediatric Surgery

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Section: Discussionsupporting

confidence: 88%

Propranolol: useful therapeutic agent for the treatment of ulcerated infantile hemangiomas

Kim

Hogeling

Wargon

et al. 2011

Journal of Pediatric Surgery

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“…In accordance with previously published data2 15, our study shows that girls face a higher risk than boys to develop an IH when born before 32nd gestational week or <1500 g. The reasons for this female preference are not completely clear so far, but it has previously been shown that haemangiomas are one of the target tissues of oestrogen and oestrogen might play an important role in the development of haemangiomas 16…”

Section: Discussionsupporting

confidence: 91%

Tocolysis with the β-2-sympathomimetic hexoprenaline increases occurrence of infantile haemangioma in preterm infants

Mayer

Minichmayr

Klement

et al. 2012

Arch Dis Child Fetal Neonatal Ed

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“…The results were then compared to published data from the Hemangioma Investigator Group (HIG) consisting of pediatric dermatology practices from multiple academic centers, comprising over 1000 patients 3, 5, 11 . Statistically significant deviations of results in the surgical population from that of the overall IH population of the HIG studies were taken to be suggestive of a particular risk factor in IH for requiring surgery.…”

Section: Methodsmentioning

confidence: 99%

A retrospective study to classify surgical indications for infantile hemangiomas

Lee

Hardy

Goltsman

et al. 2014

Journal of Plastic, Reconstructive & Aesthetic Surgery

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Summary Infantile hemangiomas (IHs) spontaneously involute, but some leave contour deformities necessitating surgical correction. There is a paucity of data reviewing predictive risk factors associated with a need for surgery to guide clinicians when counseling parents. Patients undergoing IH resection by a single surgeon from August 2004 to August 2011 were reviewed to determine patient (age, gender, birth history) and IH characteristics (size, location) associated with surgical intervention. Data were compared to published data from the Hemangioma Investigator Group (HIG). Statistical analysis was performed using Student's t-test, odds ratio, and logistic regression analysis. Out of 196 referred patients, 112 underwent surgery. There was a female preponderance (3.5:1). Two-thirds of patients (64.9%) first presented to the surgeon at <2 years of age, but most underwent surgery between 2-3 years (52.7%; average lag time, 11 months). 18 patients underwent surgery at <1 year of age. IH patients with preterm birth history had increased risk for needing surgical intervention (odds ratio 2.124, CI 1.31-3.44; p<0.0012). A majority (84.7%) of resected IHs were located on the head or neck, significantly higher than the distribution from the HIG data (62.2%; p<0.0001). Resected head and neck IHs were smaller than those below the neck (average, 8.85cm2 vs. 22.35 cm2, p=0.017). Preterm birth is associated with higher risk for requiring surgical intervention. IHs on the head and neck are more likely to be removed when compared to those below the neck, and at a smaller size threshold.

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Comparison of Infantile Hemangiomas in Preterm and Term Infants: A Prospective Study

Cited by 55 publications

References 6 publications

Propranolol: useful therapeutic agent for the treatment of ulcerated infantile hemangiomas

Propranolol: useful therapeutic agent for the treatment of ulcerated infantile hemangiomas

Tocolysis with the β-2-sympathomimetic hexoprenaline increases occurrence of infantile haemangioma in preterm infants

A retrospective study to classify surgical indications for infantile hemangiomas

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