2001
DOI: 10.1097/00003072-200108000-00004
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Abstract: These findings suggest that In-111 octreotide is superior to Tc-99m (V) DMSA and has a similar sensitivity rate to CT and MRI for the diagnosis of recurrent or metastatic MTC. Although the combined use of In-111 octreotide and Tc-99m (V) DMSA was most sensitive, the combined use of CT and MRI with radionuclide imaging methods may better detect more metastatic tumor foci.

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Cited by 40 publications
(14 citation statements)
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“…Some of these seem more sensitive and specific in the detection of MTC metastases while their diagnostic performance appears much lower in the detection of tumor remnant or recurrences after surgery. 131I-metaiodobenzylguanidine scintigraphy (MIBG) has been reported and able to detect tumor lesions in approximately one in every three patients with residual or recurrent disease after surgery, while 99mTc-dimercaptosuccinic acid and somatostatin receptor scintigraphy (SRS) tumor detection rate ranged between 35-70% and 20-64% respectively (Udelsman et al 1989, Hoefnagel et al 1991, Celentano et al 1995, Anthony et al 1996, Baudin et al 1996, Adams et al 1998a, Berna et al 1998, Arslan et al 2001. Postoperative unsuppressed calcitonin and carcinoembryonic antigen (CEA) concentrations may persist elevated during 2-3 months after surgery due to their long halflife in the blood, while progressively increasing calcitonin and CEA concentrations after this time represent a sensitive marker of MTC persistence (Leboulleux et al 2004).…”
Section: Introductionmentioning
confidence: 99%
“…Some of these seem more sensitive and specific in the detection of MTC metastases while their diagnostic performance appears much lower in the detection of tumor remnant or recurrences after surgery. 131I-metaiodobenzylguanidine scintigraphy (MIBG) has been reported and able to detect tumor lesions in approximately one in every three patients with residual or recurrent disease after surgery, while 99mTc-dimercaptosuccinic acid and somatostatin receptor scintigraphy (SRS) tumor detection rate ranged between 35-70% and 20-64% respectively (Udelsman et al 1989, Hoefnagel et al 1991, Celentano et al 1995, Anthony et al 1996, Baudin et al 1996, Adams et al 1998a, Berna et al 1998, Arslan et al 2001. Postoperative unsuppressed calcitonin and carcinoembryonic antigen (CEA) concentrations may persist elevated during 2-3 months after surgery due to their long halflife in the blood, while progressively increasing calcitonin and CEA concentrations after this time represent a sensitive marker of MTC persistence (Leboulleux et al 2004).…”
Section: Introductionmentioning
confidence: 99%
“…Tc-99m DMSA(V) is taken up by the primary as well as recurrent tumor, along with its metastasis, with sensitivity ranging from 19% to 88%. [34567891011]…”
Section: Discussionmentioning
confidence: 99%
“…In addition, there is growing interest in the use of PET with different radiotracers,[111819202122232425] that is, 3,4-dihydroxy-6-F-18-fluoro-l-phenylalanin PET-CT (F-18 DOPA PET-CT) and F-18 FDG PET-CT. Although the literature focusing on the use of PET-CT in the detection of recurrent MCT is limited, the available studies have suggested a complementary role for PET-CT and have found it to be especially useful in cases of discordance between conventional radionucleotide imaging and the serum calcitonin levels.…”
Section: Discussionmentioning
confidence: 99%
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“…Many researchers suggest that 111 In-diethylenetriaminepentaacetic acid (DTPA)-DPhe 1 -octreotide, a long-acting somatostatin analog, has a successful role in the diagnosis of residual, recurrent, and metastatic foci of MTC (Arslan et al 2001;Rufini et al 2000;Kurtaran et al 1998), being even better than CT (Krausz et al 1999). Another radiolabeled tracer is 123 I/ 131 I-meta-iodobenzylguanidine (MIBG) that has also been used for the diagnosis of MTC because 123 I/ 131 I-MIBG can be taken up and stored in catecholamine vesicles of MTC, like pheochromocytoma and neuroblastoma (Oishi et al 1986), though its sensitivity for detection of the lesions is lower than that of 111 In-DTPA-D-Phe 1 -octreotide (Kaltsas et al 2001;Lupoli et al 1991).…”
Section: Introductionmentioning
confidence: 99%