Comparison of <i><scp>DMRT</scp>3</i> genotypes among American Saddlebred horses with reference to gait

Regatieri, Inaê Cristina; Eberth, J. E.; Sarver, F.; Lear, Teri L.; Bailey, Ernest

doi:10.1111/age.12458

Cited by 12 publications

(5 citation statements)

References 6 publications

(6 reference statements)

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“…Subsequently, DMRT3 gene mutation was found to affect the Locomotion performance of horses in the Brazilian Mangalarga Marchador breed (Fonseca et al . 2017), the French trotter breed (Ricard 2015), American Saddlebred horses (Regatieri et al . 2016), Finn horses (Jäderkvist et al .…”

Section: Discussionmentioning

confidence: 99%

Genome-wide analysis reveals signatures of selection for gait traits in Yili horse

Liu

Fang

Meng

et al. 2018

Preprint

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10High quality gaits play an important role in many breeding programs, but the genes of gait 11 were limited at the moment. Here, we present an analysis of genomic selection signatures 12 in 53 individuals from two breeds, using genotype data from the Affymetrix Equine 670K 13 SNP genotyping array. The 11 selection regions of Yili horse were identified using an FST 14 statistic and XP-EHH calculated in 200-kb windows across the genome. In total, 50 genes 15 could be found in the 11 regions, and two candidate genes related to locomotory behavior 16 (CLN6, FZD4). The genome of Yili horse and Russian horse were shaped by natural and 17 artificial selection. Our results suggest that gait trait of Yili horse may related to two genes. 18 This is the first time when whole genome array data is utilized to study genomic regions 19 affecting gait in Yili horse breed.20

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Section: Discussionmentioning

confidence: 99%

Genome-wide analysis reveals signatures of selection for gait traits in Yili horse

Liu

Fang

Meng

et al. 2018

Preprint

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“…; Regatieri et al . ). Research to date suggests that for a horse to be able to pace, homozygozity for the DMRT3 mutation (A) is required (Andersson et al .…”

Section: Top 10 Snps From the Genome‐wide Association Analysismentioning

confidence: 97%

To pace or not to pace: a pilot study of four‐ and five‐gaited Icelandic horses homozygous for the DMRT3 ‘Gait Keeper’ mutation

Fegraeus

Hirschberg

Árnason³

et al. 2017

Animal Genetics

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The Icelandic horse is a breed known mainly for its ability to perform the ambling four-beat gait 'tölt' and the lateral two-beat gait pace. The natural ability of the breed to perform these alternative gaits is highly desired by breeders. Therefore, the discovery that a nonsense mutation (C>A) in the DMRT3 gene was the main genetic factor for horses' ability to perform gaits in addition to walk, trot and canter was of great interest. Although several studies have demonstrated that homozygosity for the DMRT3 mutation is important for the ability to pace, only about 70% of the homozygous mutant (AA) Icelandic horses are reported to pace. The aim of the study was to genetically compare four- and five-gaited (i.e. horses with and without the ability to pace) AA Icelandic horses by performing a genome-wide association (GWA) analysis. All horses (n = 55) were genotyped on the 670K Axiom Equine Genotyping Array, and a GWA analysis was performed using the genabel package in r. No SNP demonstrated genome-wide significance, implying that the ability to pace goes beyond the presence of a single gene variant. Despite its limitations, the current study provides additional information regarding the genetic complexity of pacing ability in horses. However, to fully understand the genetic differences between four- and five-gaited AA horses, additional studies with larger sample materials and consistent phenotyping are needed.

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“…The analysis of the selective signature at the genomic level revealed a significant selection signature at ECA23. The Chakouyi horse is famous for its inherent ability to pace, and the causative mutation of the trait was reported to be located in the DMRT3 gene at ECA23 in Icelandic horses [ 18 ], so we genotyped Chakouyi horses at the locus with a previously reported method [ 16 ] to check whether the reported locus also exists in Chakouyi horses. The results showed that the causative mutation is also harbored by the Chakouyi horses, and there is a high frequency of genotypes related to the ability to pace in Chakouyi horses.…”

Section: Discussionmentioning

confidence: 99%

“…The primers and PCR-RFLP method for genotyping the mutation associated with gait traits described previously [ 16 ] were used in the present study to investigate the alleles related to the ability to pace in Chakouyi horses. For further confirmation, the PCR products were sent to BGI (Beijing, China) for sequencing.…”

Section: Methodsmentioning

confidence: 99%

Whole-Genome Sequence Analysis Reveals the Origin of the Chakouyi Horse

Liu

Wang

et al. 2022

Genes

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The Chakouyi horse is an ancient Chinese indigenous horse breed distributed in Gansu Province in northwestern China, and is also one of the key breeds protected by the government. However, the origin of the Chakouyi horse remains unclear. As it is distributed in a key region of the Silk Road, it was speculated that the origin of the Chakouyi horse might involve the foreign horse breeds found along this ancient commercial artery. In this study, whole-genome resequencing data of 12 horse breeds, including both indigenous and foreign horses, were applied to reveal the genetic relationships between the Chakouyi horse and other breeds, as well as the ancestry of this ancient breed. An analysis of the population structure and admixture showed that there is no close genetic affinity between the Chakouyi horse and the foreign horses while Chinese indigenous horse populations were grouped together in accordance with their geographic locations, and the Chakouyi horse showed a closer relationship with Kazak horses, Mongolian horses, and Tibetan horses. The results from the ancestral composition prediction indicated that the Kazak horse and the Mongolian horse might be two ancestors of the Chakouyi horse. Furthermore, the genome-wide selection signature analysis revealed that the DMRT3 gene was positively selected in the Chakouyi horse and related to the gait trait of the breed. Our results provide insights into the native origin of the Chakouyi horse and indicate that Kazak and Mongolian horses played important roles in the formation of the Chakouyi horse. Genetic communication between the Chakouyi horse and other horse populations could be attributed, at least partially, to population migrations and trade activities along the ancient commercial routes.

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Comparison of DMRT3 genotypes among American Saddlebred horses with reference to gait

Cited by 12 publications

References 6 publications

Genome-wide analysis reveals signatures of selection for gait traits in Yili horse

Genome-wide analysis reveals signatures of selection for gait traits in Yili horse

To pace or not to pace: a pilot study of four‐ and five‐gaited Icelandic horses homozygous for the DMRT3 ‘Gait Keeper’ mutation

Whole-Genome Sequence Analysis Reveals the Origin of the Chakouyi Horse

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