Comparison of Histidine-Tryptophan-Ketoglutarate Solution and University of Wisconsin Solution in Adult Liver Transplantation

Rayya, Fadi; Harms, Jens; Martin, A.P.; Bartels, Michael; Hauss, Johann; Fangmann, J.

doi:10.1016/j.transproceed.2008.03.044

Cited by 33 publications

(30 citation statements)

References 10 publications

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“…37 Several studies support this hypothesis by demonstrating equivalent graft survival, and similar, or even lower, biliary complications. [39][40][41][42][43] We performed a subgroup analysis to evaluate what effect preservation solution had on graft and patient survival for recipients of DCD or matched recipients of DBD donors. When DCD donors were preserved with HTK, recipient survival tended to be better when compared with recipients of DBD donors preserved with either HTK or UW.…”

Section: Discussionmentioning

confidence: 99%

Liver Transplant Using Donors After Cardiac Death: A Single-Center Approach Providing Outcomes Comparable to Donation After Brain Death

Vanatta

Dean

Hathaway³

et al. 2013

Exp Clin Transplant

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Objectives: Organ donation after cardiac death remains an available resource to meet the demand for transplant. However, concern persists that outcomes associated with donation after cardiac death liver allografts are not equivalent to those obtained with organ donation after brain death. Results: Patient and graft survival rates were similar in both groups at 1 and 3 years (P = .444 and P = .295). There was no statistically significant difference in primary nonfunction, vascular complications, or biliary complications. In particular, there was no statistically significant difference in ischemic-type diffuse intrahepatic strictures (P = .107). Conclusions: These findings provide further evidence that excellent patient and graft survival rates expected with liver transplants using organ donation after brain death donors can be achieved with organ donation after cardiac death donors without statistically higher rates of morbidity or mortality when a comprehensive approach that controls for careful donor and recipient matching, surgical technique, and preservation solution is used.

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Section: Discussionmentioning

confidence: 99%

Liver Transplant Using Donors After Cardiac Death: A Single-Center Approach Providing Outcomes Comparable to Donation After Brain Death

Vanatta

Dean

Hathaway³

et al. 2013

Exp Clin Transplant

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“…Bretschneider. Initially developed for cardiac surgery, it was shown to be effective in both liver and kidney preservation, and appeared to compete with UW solution in the experimental and clinical preservation of the kidney [52] and liver [53]. Major components are the strong buffer (histidine), osmotic barrier(mannitol), and low-permeable amino acids (tryptophan and alpha-ketoglutaric acid) which help to stabilise cell membranes and may be substrates for anaerobic metabolism.…”

Section: Bretschneider's (Custodiol) Solutionmentioning

confidence: 99%

Organ Preservation: Current Concepts and New Strategies for the Next Decade

Guibert

Petrenko

Balaban

et al. 2011

Transfus Med Hemother

279

233

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Organ transplantation has developed over the past 50 years to reach the sophisticated and integrated clinical service of today through several advances in science. One of the most important of these has been the ability to apply organ preservation protocols to deliver donor organs of high quality, via a network of organ exchange to match the most suitable recipient patient to the best available organ, capable of rapid resumption of life-sustaining function in the recipient patient. This has only been possible by amassing a good understanding of the potential effects of hypoxic injury on donated organs, and how to prevent these by applying organ preservation. This review sets out the history of organ preservation, how applications of hypothermia have become central to the process, and what the current status is for the range of solid organs commonly transplanted. The science of organ preservation is constantly being updated with new knowledge and ideas, and the review also discusses what innovations are coming close to clinical reality to meet the growing demands for high quality organs in transplantation over the next few years.

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“…Importante es mencionar que inicialmente todos los hígados fueron perfundidos con UW (única solución disponible en el país); pese a lo anterior, la comparación entre ambas soluciones nos parece igualmente válida, tal como ha sido comunicada por otros autores 20,21 . La mayor cantidad de HTK utilizada respecto a UW, puede ser explicada por las recomendaciones iniciales del proveedor y eventualmente por la menor viscosidad de HTK.…”

Section: Discussionunclassified

“…Rayya y cols. 21 publicaron una sobrevida de injerto de 78% con UW y de 71% con HTK a 12 mesespost-trasplante. En tanto Mangus y cols.…”

Section: Discussionunclassified

¿Influye el medio de preservación del injerto en los resultados y costos del trasplante hepático de donante fallecido? Comparación de dos soluciones de preservación

et al. 2014

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Comparison of Histidine-Tryptophan-Ketoglutarate Solution and University of Wisconsin Solution in Adult Liver Transplantation

Cited by 33 publications

References 10 publications

Liver Transplant Using Donors After Cardiac Death: A Single-Center Approach Providing Outcomes Comparable to Donation After Brain Death

Liver Transplant Using Donors After Cardiac Death: A Single-Center Approach Providing Outcomes Comparable to Donation After Brain Death

Organ Preservation: Current Concepts and New Strategies for the Next Decade

¿Influye el medio de preservación del injerto en los resultados y costos del trasplante hepático de donante fallecido? Comparación de dos soluciones de preservación

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