Comparison of High Performance Capillary Electrophoresis and Liquid Chromatography for the Determination of Acyclovir and Guanine in Pharmaceuticals and Urine

Analysis of acyclovir by high performance capillary electrophoresis with on-column amperometric detection

“…The opitmal buffer system, 40 mmol/L borax-H 3 PO 4 (pH 2.0)-5% EtOH, for separating ACV, AMD and guanine by HPCE with UV detection, was selected as given in [6]. The standard ACV, G and AMD were separated at base line under optimal conditions.…”

Stability evaluation and sensitive determination of antiviral drug, valacyclovir and its metabolite acyclovir in human plasma by a rapid liquid chromatography–tandem mass spectrometry method

“…pharmaceuticals [7][8][9][10][11], human plasma [12][13][14][15][16][17], serum [18] and maternal plasma, amniotic fluid, fetal and placental tissues [19]. High-performance capillary electrophoresis has also been used for the determination of ACV in urine [20] and plasma [21]. A sensitive assay is reported by Jin et al [22] to determine ACV in aqueous humor by LC-MS.…”

Assay and stability‐indicating micellar electrokinetic chromatography method for the simultaneous determination of valacyclovir, acyclovir and their major impurity guanine in pharmaceutical formulations

“…Methods for the simultaneous determination of ACV and its major impurity guanine in pharmaceutical formulations (Zhang et al, 1996;Tzanavaras and Themelis, 2007;Huidobro et al, 2005) or in biological fl uids (Zhang et al, 1996;Zhang et al, 2000), have been reported using HPLC (Zhang et al, 1996;Huidobro et al, 2005;Tzanavaras and Themelis, 2007), and capillary electrophoresis (CE) (Zhang et al, 1996 and.…”