Comparison of eicosapentaenoic acid concentrations in plasma between patients with ischemic stroke and control subjects

Ikeya, Yoshimori; Fukuyama, Naoto; Kitajima, Waichi; Ogushi, Yoichi; Mori, Hiromu

doi:10.1016/j.nut.2012.05.003

Cited by 26 publications

(23 citation statements)

References 31 publications

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“…Although previous studies have suggested that higher EPA concentrations are associated with an increased incidence of intracerebral hemorrhage, our logistic analysis revealed that a lower EPA/AA ratio was a significant risk factor, and this finding is similar to our previous finding related to cardioembolism [14]. However, the ROC curve analysis revealed that the EPA/AA ratio was not a precise predictor of intracerebral hemorrhage, whereas this ratio was found to be significant predictor of cardioembolism [14]. In the subgroup analysis, EPA and not the EPA/AA ratio was found to be a significant relative risk factor in the ≥65-year-old BMI, DBP, HDL-C, EPA concentration, EPA/AA ratio, alcohol intake ≥400 mL/d (≥16-32 g/d with an assumed alcohol concentration of 5%-10%), vegetable consumption <100 g/wk, and antihypertensive drug use were found to differ significantly in the nonparametric tests between the patients with intracerebral hemorrhages and the control subjects; thus, these parameters were included in the multiple logistic analyses for intracerebral hemorrhage.…”

Section: Discussionsupporting

confidence: 91%

“…However, in the present study, we found that the EPA concentrations and the EPA/AA ratios were not higher in the patients with intracerebral hemorrhage than in the control subjects. Although previous studies have suggested that higher EPA concentrations are associated with an increased incidence of intracerebral hemorrhage, our logistic analysis revealed that a lower EPA/AA ratio was a significant risk factor, and this finding is similar to our previous finding related to cardioembolism [14]. However, the ROC curve analysis revealed that the EPA/AA ratio was not a precise predictor of intracerebral hemorrhage, whereas this ratio was found to be significant predictor of cardioembolism [14].…”

Section: Discussionsupporting

confidence: 85%

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Low plasma eicosapentaenoic acid concentration as a possible risk factor for intracerebral hemorrhage

2015

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 85%

Low plasma eicosapentaenoic acid concentration as a possible risk factor for intracerebral hemorrhage

2015

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“…The fact that they had high levels of plasma EPA and low AA concentrations suggested that their omega-3 fatty acid-rich food was implicated in this favorable outcome. 10,17) Subsequently, a number of studies reported fi ndings indicating that a low EPA/AA ratio was related with a higher incidence of cardiovascular events in the Japanese population, 18) as well as in those with a greater number of diseased coronary vessels, 19) a higher risk of cerebrovascular accident, 20) or more visceral fat, which is a major factor in metabolic syndrome. 21) With a certain amount of EPA supplementation, the EPA/ AA ratio increases without fail as shown in the current study (Figure 2A).…”

Section: Discussionmentioning

confidence: 99%

Effects of Eicosapentaenoic Acid on Platelet Function in Patients Taking Long-Term Aspirin Following Coronary Stent Implantation

et al. 2014

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SummaryEicosapentaenoic acid (EPA) has been widely accepted to have antiatherosclerotic effects. The aim of this study was to investigate the antiplatelet effect of EPA combined with acetylsalicylic acid (ASA) following stent implantation. Eighteen patients who had undergone coronary stent implantation at least 8 months previously were included. All patients were given EPA ethyl ester (EPA-E) 1.8 g/day in addition to ASA 100 mg/day for 12 weeks. After the treatment, the plasma EPA/arachidonic acid (AA) ratio increased signifi cantly from 0.40 ± 0.2 to 1.08 ± 0.39 (P < 0.001). There were no changes in the maximum platelet aggregation (MPA) induced by adenosine diphosphate (5 and 20 µmol/L), AA (0.3 and 0.5 mg/mL), or collagen (2 and 4 µg/mL). Furthermore, no signifi cant differences were observed in the expression of PAC-1 and CD62P on the platelet surface membranes or in the soluble P-selectin concentration. With further analysis, a signifi cant negative correlation was found between collagen (2 µg/mL)-induced MPA and plasma EPA/AA ratio (r = -0.507, P = 0.032). The patients were then divided into 2 groups according to the median EPA/AA ratio value of 0.92. In the high EPA/AA ratio group (n = 10), collagen-induced MPA was signifi cantly suppressed after EPA-E administration (45.3 ± 15.9 versus 39.0 ± 16.3, P = 0.033). In contrast, there were no signifi cant changes in platelet aggregation (56.0 ± 9.8 versus 57.1 ± 11.4, P = 0.745) in the low EPA/AA ratio group (n = 8). EPA treatment had a potential to suppress collagen-induced platelet aggregation in patients with a high plasma EPA/AA ratio. (Int Heart J 2014; 55: 228-233) Key words: Omega-3 polyunsaturated fatty acids, Coronary artery disease C oronary revascularization with drug-eluting stents (DES) has become a widespread technique for treating coronary artery disease (CAD). The guidelines recommend that patients with DES should receive dual antiplatelet therapy (DAPT) with acetylsalicylic acid (ASA) and thienopyridine for at least 1 year in order to prevent stent thrombosis.1,2) When the risk of stent thrombosis decreases in the chronic phase following DES implantation, secondary prevention becomes a primary target of patient care. In fact, in the chronic phase, the risks of CAD or cerebrovascular disease are much higher than that of stent thrombosis.3,4) Therefore, lifelong treatment with ASA is also recommended for the secondary prevention of atherothrombotic events following DAPT termination. 1,2)Eicosapentaenoic acid (EPA) has been widely accepted to have antiatherosclerotic effects. 5,6) In relation to secondary prevention, the use of eicosapentaenoic acid ethyl ester (EPA-E) in combination with statins successfully reduced the recurrence of cardiovascular events in the Japan EPA lipid intervention study (JELIS). 7) In particular, in patients who underwent coronary artery intervention, the JELIS sub-study showed that the incidence of major coronary events was significantly reduced by 41% in the EPA treatment group. 8) EPA is known to improve vascula...

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“…However, this ratio has not been fully investigated in peripheral artery disease 5) . A lower EPA concentration is a significant risk factor for ischemic stroke, as are a lower body mass index, lower high-density lipoprotein cholesterol, and smoking.…”

Section: Introductionmentioning

confidence: 99%

Indicator of arteriosclerosis in patients with COPD

Ebihara

Watanabe²,

Nagai

et al. 2014

HEP

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Comparison of eicosapentaenoic acid concentrations in plasma between patients with ischemic stroke and control subjects

Cited by 26 publications

References 31 publications

Low plasma eicosapentaenoic acid concentration as a possible risk factor for intracerebral hemorrhage

Low plasma eicosapentaenoic acid concentration as a possible risk factor for intracerebral hemorrhage

Effects of Eicosapentaenoic Acid on Platelet Function in Patients Taking Long-Term Aspirin Following Coronary Stent Implantation

Indicator of arteriosclerosis in patients with COPD

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