Comparison of different quantification methods of late gadolinium enhancement in patients with hypertrophic cardiomyopathy

Śpiewak, Mateusz; Małek, Łukasz A.; Miśko, Jolanta; Chojnowska, Lidia; Miłosz, Barbara; Kłopotowski, Mariusz; Petryka, Joanna; Dąbrowski, M; Kępka, Cezary; Rużyłło, Witold

doi:10.1016/j.ejrad.2009.05.035

Cited by 92 publications

(77 citation statements)

References 15 publications

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“…LGE was assessed with the use of ceCMR as previously described [8]. Briefly, breath-hold inversion recovery sequence was used with optimal inversion time to null normal myocardium.…”

Section: Methodsmentioning

confidence: 99%

Late gadolinium enhancement gray zone in patients with hypertrophic cardiomyopathy. Comparison of different gray zone definitions

Śpiewak¹,

Małek²,

Chojnowska³

et al. 2010

Int J Cardiovasc Imaging

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To quantify heterogeneous tissue at the periphery of areas of fibrosis (gray zone) in patients with hypertrophic cardiomyopathy (HCM) with the use of two different techniques. Cardiac magnetic resonance with late gadolinium enhancement analysis was performed in 33 patients with HCM. Gray zone was evaluated with the use of two different techniques previously described in patients after myocardial infarction. LGE was present in 25 (78%) patients. There was no significant difference in total LGE mass at two different cut-off values [53.8 g (interquartile range, IQR 43.5-77.8 g) vs. 53.8 g (IQR 37.8-64.5 g), respectively, P = 0.49]. Significant difference in gray zone mass assessed with the use of two techniques was demonstrated (19.1 +/- 7.3 g vs. 50.8 +/- 47.8 g; P = 0.003). There was a strong correlation between total LGE and gray zone mass (r = 0.789, P = 0.0001 for first method and r = 0.951, P < 0.0001 for the second one, respectively). However, significant variability of gray zone mass (and extent expressed as % of left ventricular mass) in patients with similar LGE size/extent was observed. Moreover, LGE mass varied greatly in patients with similar gray zone size. Neither left ventricular mass, nor with maximal wall thickness correlated with extent of gray zone assessed with both methods. The studied techniques provided similar results with regard to total LGE but significant differences were observed in gray zone mass. Two patients may have similar extent (or absolute mass) of LGE, but strikingly discrepant gray zone size.

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“…LGE was assessed with the use of ceCMR as previously described [8]. Briefly, breath-hold inversion recovery sequence was used with optimal inversion time to null normal myocardium.…”

Section: Methodsmentioning

confidence: 99%

Late gadolinium enhancement gray zone in patients with hypertrophic cardiomyopathy. Comparison of different gray zone definitions

Śpiewak¹,

Małek²,

Chojnowska³

et al. 2010

Int J Cardiovasc Imaging

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“…The presence or absence of fibrosis was assessed on visual assessment of delayed gadolinium enhancement (without thresholding), because visual assessment has been shown to correlate well with the use of a threshold of signal intensity of 6 SD above the mean for normal myocardium. 17 …”

Section: Cardiac Mrimentioning

confidence: 99%

Clinical Characteristics and Natural History of Hypertrophic Cardiomyopathy With Midventricular Obstruction

Efthimiadis

Pagourelias

Parcharidou

et al. 2013

Circ J

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“…To assess the LGE, all short-axis slices from the base to the apex were visually inspected to identify areas of a normal (completely nulled) myocardium. The mean signal intensity [and standard deviation (SD)] was derived, and a threshold of 6 SD exceeding the mean was used to define the areas of LGE (14). Summing the planimetered areas of LGE in all short-axis slices yielded the total volume (LVFM: g), which was also expressed as a proportion of the total LV myocardium (%LGE).…”

Section: Image Analysismentioning

confidence: 99%

Interrelationship between the Myocardial Mass, Fibrosis, BNP, and Clinical Outcomes in Hypertrophic Cardiomyopathy

et al. 2016

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Objective Increased left ventricular mass (LVM) and LV fibrosis mass (LVFM) are characteristics of hypertrophic cardiomyopathy (HCM). Additionally, a substantial increase in the plasma B-type natriuretic peptide (BNP) level is observed. Therefore, we investigated the interrelationship and clinical significances of these parameters in a HCM cohort that underwent cardiac MRI (CMR). Methods Patients with HCM (n=109) receiving regular outpatient treatment underwent CMR and follow-up through 2015 from CMR examinations. The clinical outcome measures were all-cause mortality, admission for worsening heart failure, and ventricular tachycardia/fibrillation. Results The baseline body mass index (BMI), LV outflow tract (LVOT) obstruction, New York Heart Association (NYHA) class, and increased left atrial dimension (LAD) index were associated with the plasma BNP level. In the CMR analysis, LVM and LVFM indices significantly correlated with the BNP level (r=0.422 and 0.368, respectively), which were independent determinants according to a multivariate analysis (p=0.009 and 0.023, respectively). A Kaplan-Meier analysis during a median follow-up of 19.4 months showed that the baseline LVM or LVFM index was not associated with the clinical outcomes. However, the baseline BNP level was significantly associated with them (p<0.001). In addition, a multivariate Cox proportional hazard analysis showed that plasma BNP was an independent predictor for the clinical outcomes after adjusting for age, sex, LVM, and LVFM. Conclusion The LVM and LVFM are determinants of the BNP level independent of the BMI, LVOT obstruction, LAD, and NYHA class in patients with HCM. However, plasma BNP may be a more sensitive integrated-marker for the clinical outcomes than LVM or LVFM.

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Comparison of different quantification methods of late gadolinium enhancement in patients with hypertrophic cardiomyopathy

Cited by 92 publications

References 15 publications

Late gadolinium enhancement gray zone in patients with hypertrophic cardiomyopathy. Comparison of different gray zone definitions

Late gadolinium enhancement gray zone in patients with hypertrophic cardiomyopathy. Comparison of different gray zone definitions

Clinical Characteristics and Natural History of Hypertrophic Cardiomyopathy With Midventricular Obstruction

Interrelationship between the Myocardial Mass, Fibrosis, BNP, and Clinical Outcomes in Hypertrophic Cardiomyopathy

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