Comparison of different criteria for periodontitis case definition in head and neck cancer individuals

Bueno, Audrey Cristina; Ferreira, Raquel Conceição; Cota, Luís Otávio Miranda; Silva, Guilherme Carvalho; Magalhães, Cláudia Silami de; Moreira, Allyson Nogueira

doi:10.1007/s00520-015-2618-8

Cited by 17 publications

(17 citation statements)

References 37 publications

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“…Clinically, the diagnosis of periodontitis is based upon assessment of clinical attachment loss (CAL), probing depth (PD) measurements, evaluation of bleeding on probing (BOP), and evidence of loss of the alveolar bone, with or without radiography [46,47]. Even though standard definitions have been proposed [46,48], there is no uniformity in the methods used in the available studies [45,46,48,49]. Moreover, the number of teeth measured also varies between studies.…”

Section: Discussionmentioning

confidence: 99%

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Periodontal Diseases as Putative Risk Factors for Head and Neck Cancer: Systematic Review and Meta-Analysis

Gopinath

Veettil

Botelho

et al. 2020

Cancers

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Whether “periodontal disease” can be considered as an independent risk factor for head and neck cancer (HNC) remains controversial. The aim of the current meta-analysis was to quantitatively assess this relationship in order to determine whether this represents a true risk factor, with implications for cancer prevention and management. PubMed, Scopus, and Embase databases were systematically searched. Selective studies were reviewed, and meta-analysis was performed to estimate the pooled odds ratio (OR) with 95% confidence intervals (CIs) on eligible studies using a random effects model. In total, 21 eligible observational studies (4 cohorts and 17 case-controls) were identified for qualitative synthesis after a review of 1051 articles. Significant heterogeneity could be identified in measures utilized for reporting of periodontal disease. Meta-analysis performed on nine studies that employed objective measures for reporting periodontal disease demonstrated a significant association between periodontal disease and HNC [OR 3.17, 95% CI, 1.78–5.64]. A diseased periodontium represents an independent risk marker, and a putative risk factor, for HNC. Prospective studies with standardized measures of periodontal disease severity and extent, integrated with microbiological and host susceptibility facets, are needed to elucidate the mechanisms of this positive association and whether treatment of the former influences the incidence and outcomes for HNC.

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Section: Discussionmentioning

confidence: 99%

“…Thus, the bias we encounter in our meta-analysis is inevitable [17,[50][51][52][53][54][55][56][57]. For the future, internationally agreed standard definitions must be used [45,49].…”

Section: Discussionmentioning

confidence: 99%

Periodontal Diseases as Putative Risk Factors for Head and Neck Cancer: Systematic Review and Meta-Analysis

Gopinath

Veettil

Botelho

et al. 2020

Cancers

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“…PD is the most frequent cause of tooth loss in humans and one of the most prevalent diseases causing considerable morbidity that places heavy economic burdens on dental health care systems and significantly impacts the quality of life . Diagnosis, treatment, and monitoring of response to therapy for PD relies on various clinical signs and symptoms such as presence of subgingival plaque and calculus, gingival bleeding, periodontal pocket depth, clinical attachment loss, and radiographically visible bone loss around teeth . Gingivitis, inflammation of gingiva without signs of bone or attachment loss is ubiquitous in children and adults globally .…”

Section: Introductionmentioning

confidence: 99%

Macrophage immunomodulation in chronic osteolytic diseases—the case of periodontitis

Sima

Viniegra

Glogauer

2018

Journal of Leukocyte Biology

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Periodontitis (PD) is a chronic osteolytic disease that shares pathogenic inflammatory features with other conditions associated with nonresolving inflammation. A hallmark of PD is inflammation‐mediated alveolar bone loss. Myeloid cells, in particular polymorphonuclear neutrophils (PMN) and macrophages (Mac), are essential players in PD by control of gingival biofilm pathogenicity, activation of adaptive immunity, as well as nonresolving inflammation and collateral tissue damage. Despite mounting evidence of significant innate immune implications to PD progression and healing after therapy, myeloid cell markers and targets for immune modulation have not been validated for clinical use. The remarkable plasticity of monocytes/Mac in response to local activation factors enables these cells to play central roles in inflammation and restoration of tissue homeostasis and provides opportunities for biomarker and therapeutic target discovery for management of chronic inflammatory conditions, including osteolytic diseases such as PD and arthritis. Along a wide spectrum of activation states ranging from proinflammatory to pro‐resolving, Macs respond to environmental changes in a site‐specific manner in virtually all tissues. This review summarizes the existing evidence on Mac immunomodulation therapies for osteolytic diseases in the broader context of conditions associated with nonresolving inflammation, and discusses osteoimmune implications of Macs in PD.

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“…Several limitations existed in observational studies on PD and cancer risk (Bueno et al, 2015 ), which became especially problematic in meta-analysis (Zeng X. et al, 2015 ). PD is extremely difficult to be measured and quantified in observational studies, because the assessment of PD requires several periodontal measurements, and clinical definitions may change over time.…”

Section: Discussionmentioning

confidence: 99%

“…PD is extremely difficult to be measured and quantified in observational studies, because the assessment of PD requires several periodontal measurements, and clinical definitions may change over time. Currently, the clinical diagnosis of PD is based on the measurement of the pocket probing depth (PPD), community periodontal index of treatment need (CPITN), clinical attachment loss (CAL), bleeding on probing (BOP), and alveolar bone loss (ABL) with or without radiographic examinations (Bueno et al, 2015 ). The self-reported questionnaire is also commonly used in epidemiological investigations.…”

Section: Discussionmentioning

confidence: 99%

Periodontal Disease and Risk of Bladder Cancer: A Meta-Analysis of 298476 Participants

Xie

Jin

et al. 2018

Front. Physiol.

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Objective: It has been reported that the periodontal disease is linked to a number of malignant tumors such as lung cancer and pancreatic cancer. In this study, we aimed to investigate the association of periodontal disease with risk of bladder cancer by a meta-analysis.Methods: PubMed, Scopus, ScienceDirect, and Chinese National Knowledge Infrastructure (CNKI) were searched for eligible publications up to December 15, 2017. Cohort and nested case-control studies on the association between periodontal disease and risk of bladder cancer were included. After study selection and data extraction, pooled hazard ratios (HRs) and their 95% confidence intervals (95%CIs) were calculated using a fixed-effect inverse-variance model. All analyses were performed using the RevMan 5.3 software.Results: Finally, five cohort studies were identified and included in this meta-analysis, involving 1,104 bladder cancer cases of 298,476 participants. Summary estimates based on adjusted data showed that periodontal disease was not significantly associated with the risk of bladder cancer (HR = 1.09, 95% CI = 0.95–1.25, I2 = 0%). A similar result was also observed after cumulative, subgroup and sensitivity analyses.Conclusions: Current evidence from cohort studies suggests that patients with periodontal disease may not be at an increased risk of developing bladder cancer.

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Comparison of different criteria for periodontitis case definition in head and neck cancer individuals

Abstract: Definition 1 was the most accurate criterion to case periodontitis definition to be applied to head and neck cancer individuals.

Cited by 17 publications

References 37 publications

Periodontal Diseases as Putative Risk Factors for Head and Neck Cancer: Systematic Review and Meta-Analysis

Periodontal Diseases as Putative Risk Factors for Head and Neck Cancer: Systematic Review and Meta-Analysis

Macrophage immunomodulation in chronic osteolytic diseases—the case of periodontitis

Periodontal Disease and Risk of Bladder Cancer: A Meta-Analysis of 298476 Participants

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