Comparison of different concentrations of calendula officinalis gel on cutaneous wound healing

Shafeie, Nazanin; Naini, Abotorab Tabatabai; Jahromi, Hossein Kargar

doi:10.13005/bpj/850

Cited by 27 publications

(42 citation statements)

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“…Seven preclinical studies were included in this systematic review. Sample size in the studies varied from 12 to 75 rats/mice (see Table ). Two studies addressed burns, of which one included female rats as the animal model and the other hairless mice .…”

Section: Resultsmentioning

confidence: 99%

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A systematic review of Calendula officinalis extract for wound healing

Givol

Kornhaber

Visentin

et al. 2019

Wound Repair Regeneration

103

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Use of complementary and alternative medicine for wound healing is influencing mainstream medical practice. This systematic review evaluates the role of Calendula officinalis flower extract as monotherapy compared to control for wound healing in vivo. Searches were conducted in PubMed, EMBASE, Cochrane Central Register of Controlled Trials, CINAHL, and Scopus (up to April 2018) with 14 studies meeting the inclusion criteria, comprising 7 animal experiments and 7 clinical trials. Findings from the review on acute wound healing showed faster resolution of the inflammation phase with increased production of granulation tissue in the test groups treated with extract. These findings were consistent in five animal studies and one randomized clinical trial. Chronic wound healing studies were varied. Two clinical control studies on venous ulcers demonstrated decreased ulcer surface area compared to controls. Another randomized clinical trial demonstrated no improvement for the calendula group in diabetic leg ulcer healing. Burn healing similarly showed mixed results. Two animal studies demonstrated a prophylactic effect for the administration of calendula extract prior to burn injury. A randomized clinical trial of patients suffering from partial to full thickness burns demonstrated no benefit for topical application of calendula extract compared to controls. Two randomized clinical trials assessed the potential for extract to prevent acute post radiation dermatitis, with one study showing improvements compared to trolamine, while the other found no improvement compared to aqua gel cream. Animal studies provide moderate evidence for improved recovery from the inflammation phase and increased production of granulation tissue in calendula extract treatment groups. This review identified some evidence for the beneficial effects of C. officinalis extract for wound healing, consistent with its role in traditional medicine. There is a need for larger, well‐designed randomized control trials to assess the effect of calendula on wound healing including complications.

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Section: Resultsmentioning

confidence: 99%

“…Two studies addressed burns, of which one included female rats as the animal model and the other hairless mice . The remaining five studies addressed full thickness wounds, one with mice as the animal model, and the other four studies with rats …”

Section: Resultsmentioning

confidence: 99%

A systematic review of Calendula officinalis extract for wound healing

Givol

Kornhaber

Visentin

et al. 2019

Wound Repair Regeneration

103

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show abstract

“…7% gel showed highest tensile strength. At microscopic level, the treated tissue at 14 th post-injury day showed epithelialization, few macrophages, lymphocytes, fibroblasts and loops of new blood vessels (Shafeie et al, 2015).…”

Section: Calendula Officinalismentioning

confidence: 97%

Medicinal plants with wound healing potential

Firdous¹,

Sautya²

2018

Bangladesh J Pharmacol

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“…Skin wounds of varying degrees of severity can occur because of burns, cuts, abrasions, and ulcers. If not repaired, any breach of the skin may compromise its barrier function and expose the body's tissues to microbial infections and mechanical damage . Wound healing is a complicated process of skin repair after injury.…”

Section: Introductionmentioning

confidence: 99%

“…If not repaired, any breach of the skin may compromise its barrier function and expose the body's tissues to microbial infections and mechanical damage. 1 Wound healing is a complicated process of skin repair after injury. Wound healing requires a series of coordinated actions, including fibroblast proliferation and migration and the coordination of several cell types, including keratinocytes, fibroblasts, endothelial cells, macrophages, and platelets.…”

Section: Introductionmentioning

confidence: 99%

Exogenous CLASP2 protein treatment enhances wound healing in vitro and in vivo

Kim

Lee

Yoo

et al. 2019

Wound Repair Regeneration

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Proliferative and migratory abilities of fibroblasts are essential for wound healing at the skin surface. Cytoplasmic linker‐associated protein‐2 (CLASP2) was originally found to interact with cytoplasmic linker protein (CLIP)‐170. CLASP2 plays an important role in microtubule stabilization and the microtubule‐stabilizing activity of CLASP2 depends on its interactions with end binding (EB)‐1 and CLIP‐170. Although the microtubule‐stabilizing role of CLASP2 is well established, the effects of CLASP2 on the migration and proliferation of fibroblasts remain unclear in the context of wound healing. Therefore, we tested the utilization of CLASP2 as a directly applied protein drug to improve wound healing by promoting the migration of effector cells, including skin fibroblasts, to the site of repair or injury using an in vivo excisional wound mouse model and in vitro Hs27 skin fibroblast model. Epidermal growth factor, which is a recognized contributor to cell proliferation and migration, was used as positive control. In vitro and in vivo, CLASP2 treatment significantly enhanced cell migration and accelerated wound closure. Furthermore, in vivo, the CLASP2‐treated animal group displayed enhanced epidermal repair and collagen deposition. Next, we studied the mechanism of CLASP2 for wound healing. Increasing the abundance of intracellular free CLASP2 in skin fibroblasts by supplying exogenous CLASP2 seemed to stabilize microtubules through an interaction between CLASP2 and CLIP‐170, as well as EB1. Exogenous CLASP2 also showed direct binding with IQGAP1, increasing both cyclic adenosine monophosphate activity and phosphorylation of glycogen synthase kinase 3β, which in turn reinstated the binding between free CLASP2 and IQGAP1. In summary, exogenous CLASP2 increased Hs27 skin fibroblast migration by interacting with IQGAP1 and other cytoskeletal linker proteins, such as CLIP‐170 and EB1. Our results strongly suggest that CLASP2 can be developed in wound healing drugs for skin repair and/or regenerating cosmetic products.

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Comparison of different concentrations of calendula officinalis gel on cutaneous wound healing

Cited by 27 publications

References 0 publications

A systematic review of Calendula officinalis extract for wound healing

A systematic review of Calendula officinalis extract for wound healing

Medicinal plants with wound healing potential

Exogenous CLASP2 protein treatment enhances wound healing in vitro and in vivo

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