Comparison of D&amp;C and hysterectomy pathologic findings in endometrial cancer patients

Huang, Ziying; Di, Wen; Lin, Qi

doi:10.1007/s00404-004-0712-0

Cited by 20 publications

(21 citation statements)

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“…According to the literature, the agreement levels between the endometrial sampling diagnosis and the final surgical pathology range from 30 to 60% [10,11,13,15,21]. The highest level of discrepancy is observed for histological grading [10,11,13,15,21].…”

Section: Discussionmentioning

confidence: 99%

“…The final surgical pathology confirms the initial diagnosis least frequently in the case of well-differentiated cancers. The concordance level increases with the degree of cancer aggressiveness [10][11][12][13][14][15].…”

Section: Discussionmentioning

confidence: 99%

“…The diagnosis is based on the histological examination of endometrial samples. However, discrepancy between histological findings before and after surgery is well-documented [8][9][10][11][12]. The clinical implications are serious considering the potential effects on surgical staging www.…”

Section: Introductionmentioning

confidence: 99%

“…journals.viamedica.pl/ginekologia_polska decisions and disease outcomes. With a preoperative diagnosis of atypical hyperplasia of the endometrium, the scope of planned surgical treatment may be inadequate when endometrial cancer is ultimately diagnosed at hysterectomy [8][9][10] and that is why accuracy of preoperative histology is very important. In cases of a malignant tumour of the uterine corpus, pathological findings in the hysterectomy specimens usually confirm the preoperative diagnosis.…”

Section: Introductionmentioning

confidence: 99%

“…In cases of a malignant tumour of the uterine corpus, pathological findings in the hysterectomy specimens usually confirm the preoperative diagnosis. Any discrepancies usually concern the histological type and grade of endometrial cancer [10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Comparison of endometrial biopsy and postoperative hysterectomy specimen findings in patients with atypical endometrial hyperplasia and endometrial cancer

Kisielewski

Gajewska

Marczewska³

et al. 2016

Ginekol Pol

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Objectives: The aim of the study was to assess the concordance between the preoperative endometrial sampling and microscopic examination of the hysterectomy specimens in patients surgically treated for atypical endometrial hyperplasia and endometrial carcinoma. Material and methods:We analysed a group of 204 patients, of whom 160 (78.43%) underwent surgical treatment for cancer of the corpus uteri and 44 (21.57%) for atypical endometrial hyperplasia. The preoperative diagnosis was based on the histological examination of endocervical and endometrial samples obtained by fractional curettage and it was compared to the histological findings at hysterectomy. The comparison was made for the basic diagnosis, the histological type of the cancer and the grade of tumour differentiation.Results: When the histological types of cancer diagnosed in endometrial curettage and hysterectomy specimens were compared, the concordance was observed in 134/160 patients (83.75%). The highest concordance was found for endometrioid carcinoma (127/148 patients, 85.81%). The grade of tumour differentiation was accurate in 69.31% of patients. The highest concordance was for moderately differentiated carcinomas. Of 44 patients who underwent surgical treatment for atypical endometrial hyperplasia, the preoperative diagnosis was confirmed by the postoperative histopathological examination in 21 patients (47.73%). In 15 patients (34.09%) endometrial cancer was diagnosed at hysterectomy. Conclusions:In endometrial cancer our findings demonstrate a high level of concordance between the histological diagnosis on endometrial curettage and at hysterectomy. Own observations have confirmed that over 30% of patients undergoing surgical treatment for atypical endometrial hyperplasia have concurrent endometrial cancer which is determined by surgery.

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