Comparison of cryotherapy and photodynamic therapy in treatment of oral leukoplakia

Efficacy of photodynamic therapy in the management of oral premalignant lesions. A systematic review

“…The total number of premalignant lesions reported in these studies [9,[15][16][17][18][19][20][21][22][23][24][25][26], ranged between 5 and 225 lesions. Twelve studies [9,[15][16][17][18][19][20][21][22][23][24]26] reported the site of lesions, which included, buccal and labial mucosa (maxilla and mandible), tongue, palate, floor of the mouth, bucco-gingival sulcus, retromolar area, maxillary tuberosity and upper and lower alveolus ( Table 1). …”

“…Twenty-three studies, which did not fulfill the eligibility criteria, were excluded (Appendix A). In total, 13 studies [9,[15][16][17][18][19][20][21][22][23][24][25][26] were included and processed for data extraction. The pattern of the present study was customized to mainly summarize the relevant information.…”

“…Seven studies [9,15,16,[20][21][22][23] reported the mean age of study participants, which was between 51 years and 62.2 years (age range 30-98 years). Nine studies [9,15,16,[18][19][20][21][22][23] reported the gender of subjects, in which the number of female participants ranged between 0 and 65 individuals.…”

“…In the study by Kawczyk-Krupka et al [18], efficacy of PDT was compared with that of cryosurgery (control group) in the management of oral premalignant lesions. The postoperative follow up period ranged from 5 months up to 7.3 years (Table 1).…”

“…Results from these studies [15,16] suggest that PDT is a potential therapeutic strategy for the management of oral premalignant lesions. However, studies [17,18] have also reported recurrence rates of up to 36% following treatment of oral premalignant lesions using PDT. In this regard, it seems that there is a controversy over the effectiveness of PDT in the management of oral premalignant lesions.…”