Comparison of contrast‐enhanced ultrasonography with virtual touch tissue quantification in the evaluation of focal liver lesions

Wu, Jingping; Shu, Rui; Yang, Zhao; Ma, Guolin; Xue, Wei; He, Qijia; Hao, Meina; Liu, Yawu

doi:10.1002/jcu.22335

Cited by 7 publications

(7 citation statements)

References 38 publications

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“…Twelve studies [19–30] used pSWE as the diagnostic imaging modality; the other 3 studies [31–33] performed 2D-SWE imaging modality. Ten studies [19, 20, 22, 23, 26, 28, 29, 31–33] exclusively reported the cut-off value of the SWV/elasticity in FLL, whereas 4 studies [21, 24, 25, 30] reported the cut-off value of the SWV/elasticity and the cut-off value of the SWV ratio. In addition, 1 study [27] reported the sum of the SWV (FLL and surrounding liver parenchyma).…”

Section: Resultsmentioning

confidence: 99%

Diagnostic effect of shear wave elastography imaging for differentiation of malignant liver lesions: a meta-analysis

Huang

Chen

et al. 2019

BMC Gastroenterol

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Background Shear wave elastography (SWE) imaging have been proposed for characterization of focal liver lesions. We conducted a meta-analysis to evaluate the accuracy and clinical utility of SWE imaging for differentiation of malignant and benign hepatic lesions. Methods PubMed, Embase, Web of Science, and the Cochrane Library were systematically reviewed to search for studies published between January 1, 1990, and November 30, 2018. The studies published in English relating to the evaluation the diagnostic accuracy of SWE imaging for distinguishing malignant and benign liver lesions were retrieved and examined for pooled sensitivity, specificity, likelihood ratios, and diagnostic odds ratios, using bivariate random-effects models. The hierarchical summary receiver operating characteristic (HSROC) curve was estimated to assess the SWE imaging accuracy. The clinical utility of SWE imaging for differentiation of malignant liver lesions was evaluated by Fagan plot. Results A total of 15 studies, involving 1894 liver lesions in 1728 patients, were eligible for the meta-analysis. The pooled sensitivity and specificity for identification of malignant liver lesions were 0.82 (95% CI: 0.77–0.86) and 0.82 (95% CI: 0.76–0.87), respectively. The AUC was 0.89 (95% CI: 0.86–0.91). When the pre-test probability was 50%, after SWE imaging measurement over the cut-off value (positive result), the corresponding post-test probability for the presence of malignant liver lesions was 82%; the post-test probability was 18% after negative measurement. Conclusions SWE imaging showed high sensitivity and specificity in differentiating malignant and benign liver lesions and may be promising for noninvasive evaluation of liver lesions. Trial registration The review was registered in the International Prospective Register of Systematic Reviews (PROSPERO): CRD42018104510 . Electronic supplementary material The online version of this article (10.1186/s12876-019-0976-2) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

Diagnostic effect of shear wave elastography imaging for differentiation of malignant liver lesions: a meta-analysis

Huang

Chen

et al. 2019

BMC Gastroenterol

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“…Considering that pSWE is a noninvasive and reproducible method that can be used in liver fibrosis assessment, several recent studies sought to investigate pSWE performance for FLL evaluation, with a target to differentiate the large number of FLLs and to characterize their cancerous/benign state [ 139 , 140 , 141 , 142 , 143 , 144 , 145 , 146 , 147 , 148 , 149 , 150 , 151 , 152 , 153 , 154 ].…”

Section: Ultrasound Elastography: a New Tool In The Characterizatimentioning

confidence: 99%

“…Table 5 presents a collection of shear wave velocity values (mean in m/s, range) measured by pSWE in different types of FLLs: HCC, metastases, hemangiomas, focal nodular hyperplasia (FNH), and adenomas, as well as the corresponding SWV cut-off values (m/s) for discriminating between the malignant versus benign FLL status. Literature data suggest that malignant FLLs are generally stiffer than their benign counterparts [ 152 , 155 ]; HCCs are overall softer than other malignant tumors [ 140 , 141 , 143 ], with SWS values varying from 2.17 ± 0.85 m/s in the Gallotti study [ 143 ] to 3.07 ± 0.89 m/s in the Guo study [ 146 ]. Several elastographic FLL studies report the following descending order of stiffness, based on the ARFI method: Metastases > HCC > FNH > hemangiomas [ 140 , 147 , 148 ].…”

Section: Ultrasound Elastography: a New Tool In The Characterizatimentioning

confidence: 99%

“…Of note is the SWV value similarity between different pathological processes, such as between HCC and FNH [ 147 , 148 ] and even between the malignant category and the benign category in the Dong study [ 145 ]. A plausible explanation for these overlaps include the level of fibrous tissue in the focal lesion, as well as the vascularization; whilst fibrous tissue tends to increase stiffness, highly vascularized lesions tend to be softer [ 152 ]. These factors may limit the diagnostic capability of ARFI for the precise diagnostic of the FLL.…”

Section: Ultrasound Elastography: a New Tool In The Characterizatimentioning

confidence: 99%

“…Furthermore, the wide range of stiffness values/SWVs of FLLs leads to value overlapping between malignant and benign lesions, leading to a diagnostic confusion [ 144 ]. Sampling bias is another error point that is worth mentioning [ 152 ]; Frulio et al suggested that different measurement findings in studies that compare benign versus malignant lesions can be explained by different proportions of these FLLs in the study samples. For example, a significantly larger number of patients with FNH could increase the mean SWV value of the benign FLLs group, as was the case in the same study by Frulio et al [ 144 ].…”

Section: Ultrasound Elastography: a New Tool In The Characterizatimentioning

confidence: 99%

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Hepatocellular Carcinoma and Non-Alcoholic Fatty Liver Disease: A Step Forward for Better Evaluation Using Ultrasound Elastography

Lupșor-Platon

Şerban

Silion

et al. 2020

Cancers

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The increasing prevalence of non-alcoholic fatty liver disease (NAFLD) in the general population prompts for a quick response from physicians. As NAFLD can progress to liver fibrosis, cirrhosis, and even hepatocellular carcinoma (HCC), new non-invasive, rapid, cost-effective diagnostic methods are needed. In this review, we explore the diagnostic performance of ultrasound elastography for non-invasive assessment of NAFLD and NAFLD-related HCC. Elastography provides a new dimension to the conventional ultrasound examination, by adding the liver stiffness quantification in the diagnostic algorithm. Whilst the most efficient elastographic techniques in staging liver fibrosis in NAFLD are vibration controlled transient elastography (VCTE) and 2D-Shear wave elastography (2D-SWE), VCTE presents the upside of assessing steatosis through the controlled attenuation parameter (CAP). Hereby, we have also critically reviewed the most important elastographic techniques for the quantitative characterization of focal liver lesions (FLLs), focusing on HCC: Point shear wave elastography (pSWE) and 2D-SWE. As our paper shows, elastography should not be considered as a substitute for FLL biopsy because of the stiffness values overlap. Furthermore, by using non-invasive, disease-specific surveillance tools, such as US elastography, a subset of the non-cirrhotic NAFLD patients at risk for developing HCC can be detected early, leading to a better outcome. A recent ultrasomics study exemplified the wide potential of 2D-SWE to differentiate benign FLLs from malignant ones, guiding the clinician towards the next steps of diagnosis and contributing to better long-term disease surveillance.

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Contrast-enhanced ultrasound for needle biopsy of central lung cancer with atelectasis

et al. 2017

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Comparison of contrast‐enhanced ultrasonography with virtual touch tissue quantification in the evaluation of focal liver lesions

Abstract: CEUS is superior to VTQ in diagnosing malignant FLLs. Adding VTQ to CEUS did not improve the diagnosis of FLLs. © 2016 Wiley Periodicals, Inc. J Clin Ultrasound 44:347-353, 2016.

Cited by 7 publications

References 38 publications

Diagnostic effect of shear wave elastography imaging for differentiation of malignant liver lesions: a meta-analysis

Diagnostic effect of shear wave elastography imaging for differentiation of malignant liver lesions: a meta-analysis

Hepatocellular Carcinoma and Non-Alcoholic Fatty Liver Disease: A Step Forward for Better Evaluation Using Ultrasound Elastography

Contrast-enhanced ultrasound for needle biopsy of central lung cancer with atelectasis

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