Comparison of cognitive adverse effects and efficacy of 2 pulse widths (0.5 ms and 1.5 ms) of brief pulse bilateral electroconvulsive therapy in patients with schizophrenia – A randomized single blind controlled trial

Ithal, Dhruva; Arumugham, Shyam Sundar; Kumar, Channaveerachari Naveen; Venkatapura, Ramesh J.; Thirthalli, Jagadisha; Gangadhar, Bangalore N.

doi:10.1016/j.schres.2019.11.062

Schizophrenia Research

2020

DOI: 10.1016/j.schres.2019.11.062

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Comparison of cognitive adverse effects and efficacy of 2 pulse widths (0.5 ms and 1.5 ms) of brief pulse bilateral electroconvulsive therapy in patients with schizophrenia – A randomized single blind controlled trial

Dhruva Ithal

Shyam Sundar Arumugham

Channaveerachari Naveen Kumar

et al.

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Cited by 3 publications

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“…The initial seizure threshold (IST) for 0.5 ms is probably about half the IST for 1.0 ms (see for comparison the IST for 0.3 ms vs. 1.5 ms in patients with depression in [4] and IST for 0.5 ms vs. 1.5 ms in patients with schizophrenia in [2]. Therefore, if we use 0.5 ms with the 'half age" dosing strategy instead of 1.0 ms with the same total energy setting (e.g.…”

mentioning

confidence: 99%

The likeliness of 0.5 and 1.0 ms stimuli in BL ECT

Spaans

2020

Eur Arch Psychiatry Clin Neurosci

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mentioning

confidence: 99%

The likeliness of 0.5 and 1.0 ms stimuli in BL ECT

Spaans

2020

Eur Arch Psychiatry Clin Neurosci

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Comparable effects of 0.5 ms and 1.5 ms pulse-widths on cardiovascular response in schizophrenia patients receiving electroconvulsive therapy

Ithal¹,

Mitra

Nallur

et al. 2021

Journal of Psychiatric Research

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Specificity of seizure genesis during electroconvulsive therapy and modified pentylenetetrazole kindling

Kozlovskii,

Kosterin,

Lepik

et al. 2023

Medicinskij alfavit

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Comparison of the development of chemically induced seizures in the experiment with the change in convulsive thresholds during electroconvulsive therapy (ECT) has demonstrated that repeated ‘chemical’ seizures can initiate the development of the kindling phenomenon, but regular ECT from the first to the 14th session most likely cause an increase in convulsive thresholds. However, the repeated ECT over 15 sessions is associated with a rapid decrease in the threshold current dose and probable dysregulation of endogenous anticonvulsant mechanisms, with the risk of the development of uncontrolled paroxysmal conditions and the risk of organic CNS lesions. The mechanisms of the convulsive action of ECT and pentylenetetrazolinduced kindling are fundamentally different. Differences in the pathogenesis of systemic convulsive reactions determine the divergent change in seizure thresholds during ECT and pentylenetetrazol stimulations.

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Comparison of cognitive adverse effects and efficacy of 2 pulse widths (0.5 ms and 1.5 ms) of brief pulse bilateral electroconvulsive therapy in patients with schizophrenia – A randomized single blind controlled trial

Cited by 3 publications

References 13 publications

The likeliness of 0.5 and 1.0 ms stimuli in BL ECT

The likeliness of 0.5 and 1.0 ms stimuli in BL ECT

Comparable effects of 0.5 ms and 1.5 ms pulse-widths on cardiovascular response in schizophrenia patients receiving electroconvulsive therapy

Specificity of seizure genesis during electroconvulsive therapy and modified pentylenetetrazole kindling

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