One of the most common reasons for emergency department (ED) admissions is sore throat, which is a prevalent clinical manifestation disturbing patients, especially with upper respiratory tract infections (URTI). Some patients with URTI present to ED with moderate to severe sore throat pain. 1 In such a case, the primary goal of treatment in ED is to alleviate pain immediately and maximising patient comfort with minimum side effects.Relieving sore throat pain in both acute and chronic periods is an indispensable aspect of treatment in URTI. As in other pain types, sore throat has also been treated over years with non-steroidal anti-inflammatory drugs (NSAIDs). Paracetamol and dexketoprofen are among the widely used analgesics administered to cure sore