Comparison of Clinical and Radiological Parameters at Knee Osteoarthritis

Abstract

Introduction:Osteoarthritis (OA) or arthrosis represents an inflammatory disease of joints that develops as a result of interaction of mechanical and biological parameters. With disease development, degenerative changes on joint cartilage can be noticeable that affect and cause pathological changes on other parts of a joint resulting in pain and dysfunction of a joint. A. E. Garrod in 1907 described osteoarthritis as a special clinical entity and separated it from a rheumatoid arthritis. OA is characterized with loss of a joint cartilage, development of new bone tissue under affected cartilage (subchondral bone) and development of osteophytes on joint edge. First sign of a disease is pain after period of relaxation that slowly intensifies.Material and Methods:In this paper, 40 patients have been analyzed with clinical and radiological signs of OA of the knee joint. Radiological classification was done by Ahlback’s classification.Results:In our study female gender was more affected with average age of 63 years. On Ahlback classification, grade II was represented the most. Comparison between clinical and radiological signs showed that there was no significant difference between established grade of OA. Wide spectrum of visible radiological osteoarthritis changes on joints is in correlation with the age of examinees.

The correlation between clinical and radiological severity of osteoarthritis of the knee

“…Our study found no correlation between either the WOMAC score or KSS score when compared to the severity of the radiographs as classified by either KL or Ahlbäck ( Figure 7 ). This is in keeping with the results found by Talic-Tanovi et al and Szebenyi et al However, we did not, find a correlation between subchondral sclerosis and pain as found by Szebenyi et al [ 8 , 16 , 19 ]. This is in contrast to Kocak et al, who found that higher patients with higher-grade radiological gradings suffer from more severe clinical features [ 17 ].…”

“…In our study, the vast majority (92%) of participants were female. This correlates to previous studies that showed a higher incidence of OA in females [ 14 , 19 ]. Western Ontario and McMaster Osteoarthritis Index (WOMAC) score consist of three subsections: Pain, stiffness and function.…”

A Histopathological Scheme for the Quantitative Scoring of Intervertebral Disc Degeneration and the Therapeutic Utility of Adult Mesenchymal Stem Cells for Intervertebral Disc Regeneration

“…The proposed scheme should be suitable for the description of DDD in any large animal and human IVD. Use of this scheme may further identify that like degenerative arthritic changes in OA and RA [ 196 , 197 , 198 , 199 , 200 , 201 , 202 , 203 ], DDD displays a spectrum of degenerative features and several sub-types of DDD are likely to be identified in the future when sufficient data is collected for critical evaluation. However for such a development to occur one must have a reliable, discriminative scoring scheme capable of evaluating the relative importance of each of the listed degenerative features of DDD.…”

Aberrant activation of latent transforming growth factor-β initiates the onset of temporomandibular joint osteoarthritis

“… 20 – 23 However, subchondral bone in OA is subjected to a decrease rather than an increase in bone stiffness. 24 , 25 In addition, uncoupled bone remodelling by osteoclasts and osteoblasts in subchondral bone contributes to cartilage degeneration, which gradually results in TMJ-OA lesions. 13 , 26 …”