Comparison of bone marrow mesenchymal stem cells with bone marrow-derived mononuclear cells for treatment of diabetic critical limb ischemia and foot ulcer: A double-blind, randomized, controlled trial

Activity of mesenchymal stem cells in therapies for chronic skin wound healing

“…52 Despite any effects on healing, there was some doubt as to any reduction in limb amputation rate or relative pain levels among groups, a major consideration for effective therapy in chronic wounds. 53 In general, the consensus from completed trials has been an overall improvement in chronic wound closure with application of mesenchymal stem cells, particularly as a part of a matrix delivery system (wound gel, etc. ).…”

“…Recent studies have outlined some successful approaches to promoting wound healing with MSCs, including autologous bone marrow-derived MSCs in fibrin matrix 52 or, more recently, intramuscular injection of autologous MSCs to improve diabetic wound closure. 54 While some trials have been aimed primarily at safety of MSC use for wound healing, 50 several clinical trials have shown the potential benefit of MSCs for inclusion in wound healing devices, including improved average rate of wound healing and general limb perfusion after treatment 53 and also improved acute wound healing correlating to the number of injected cells. 52 Despite any effects on healing, there was some doubt as to any reduction in limb amputation rate or relative pain levels among groups, a major consideration for effective therapy in chronic wounds.…”

Do Mesenchymal Stem Cells Have a Role to Play in Cutaneous Wound Healing?

“…Similarly, Lu et al analyzed the effect of intramuscular injections of BM-MSCs, BM-mononuclear cells or normal saline on 41 type-II diabetic patients with bilateral diabetic critical limb ischemia and foot ulcers. 77 Their results showed that the patients who received BM-MSCs had higher healing rates and limb perfusion compared with those who received the BM-mononuclear cells or those in the normal saline groups. The authors did not find any significant difference between the groups in terms of pain relief and amputation.…”

Clinical observation of the application of autologous peripheral blood stem cell transplantation for the treatment of diabetic foot gangrene

“…Stem cell transplantation may involve a variety of cell types, including autologous peripheral blood, bone marrow mesenchymal (23), autologous bone marrow (24) and umbilical cord blood (25,26) stem cells. The collection of bone marrow requires epidural anesthesia or general anesthesia and is more stressful for the general condition of a patient.…”