Comparison of Blood Cells Parameters  and Complete Blood Count in Diabetic  Patients: A Cross-sectional Study

Foroutan, Majid; Nassaji, Mohammad; Oruji, Fatemeh

doi:10.9734/jamps/2022/v24i10579

Cited by 1 publication

(2 citation statements)

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“…Furthermore, Naredi et al reported that high WBC values may indicate subclinical inflammation in diabetic patients [55]. Besides this study, numerous other studies have reported that WBC counts are significantly higher in diabetic patients than in healthy individuals [54,[56][57][58].…”

Section: Fructosamine and Blood Countsupporting

confidence: 55%

“…The WBC count in the blood count test can demonstrate the presence of inflammation in many diseases [53]. Therefore, increased WBC levels may predict a further decline in insulin activity and the progression of diabetes [54]. Furthermore, Naredi et al reported that high WBC values may indicate subclinical inflammation in diabetic patients [55].…”

Section: Fructosamine and Blood Countmentioning

confidence: 99%

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Investigation of Antihyperalgesic Effects of Different Doses of Sildenafil and Metformin in Alloxan-Induced Diabetic Neuropathy in Mice

PUȘCAȘU

2023

FARMACIA

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Neuropathy is one of the most frequent and continuously growing complications of diabetes. Due to the multitude of mechanisms involved in the pathogenesis of diabetic neuropathy and the fact that current therapeutic strategies have limited success in relieving pain, the aim of our study was to investigate the antihyperalgesic action of two possible effective therapeutic agents: sildenafil (a phosphodiesterase 5 inhibitor) and metformin (an antihyperglycemic). Three consecutive doses of 150 mg/kg bw of alloxan were used to induce diabetic neuropathy. Metformin showed an antihyperalgesic effect for all 3 tested doses (150 mg/kg bw, 250 mg/kg bw and 500 mg/kg bw), while for sildenafil, only doses of 2.5 mg/kg bw and 3 mg/kg bw demonstrated a significant increase in pain reaction latency after 14 days of treatment in the hot-plate test. On the other hand, metformin 150 mg/kg bw, metformin 500 mg/kg bw, sildenafil 1.5 mg/kg bw and sildenafil 3 mg/kg bw showed the best antihyperlagesic effect in the tail withdrawal test after 14 days of treatment. Blood count highlighted increased WBC (white blood cells) values and decreased RBC (red blood cells), Hb (haemoglobin), and Hct (haematocrit) values in all diabetic groups, except the metformin 250 mg/kg bw and metformin 500 mg/kg bw groups, which showed the best glycaemic control according to blood fructosamine values. These findings indicate that alterations in blood count parameters may be prevented by good glycemic control. MPV (mean platelet volume) values were statistically increased for all diabetic groups when compared to the non-diabetic control group. Further studies are needed to investigate the mechanisms of action involved in antihyperalgesic activity. RezumatNeuropatia este una dintre cele mai frecvente și în continuă creștere complicații ale diabetului. Datorită multitudinii de mecanisme implicate în patogeneza neuropatiei diabetice și a faptului că strategiile terapeutice actuale au un succes limitat în ameliorarea durerii, scopul cercetării noastre a fost investigarea acțiunii antihiperalgice a doi agenți terapeutici, sildenafil (inhibitor de fosfodiesterază V) și metformin (antihiperglicemiant). Inducerea diabetului s-a realizat prin administrarea a 3 doze consecutive de 150 mg/kg corp aloxan. Metformin a prezentat efect antihiperalgic pentru toate cele 3 doze testate (150 mg/kg corp, 250 mg/kg corp și 500 mg/kg corp), în timp ce pentru sildenafil, doar dozele de 2,5 mg/kg corp și 3 mg/kg corp au prezentat o creștere seminificativă statistic a latenței reacției la durere după 14 zile de tratament în testul hot-plate. Pe de altă parte, metformin în dozele de 150 mg/kg corp și 500 mg/kg corp, și sildenafil 1,5 mg/kg corp și 3 mg/kg corp au dovedit cel mai bun efect antihiperalgic în testul de retracție a cozii a după 14 zile de tratament. Hemoleucograma a evidențiat creșterea valorilor leucocitelor și scăderea valorilor eritrocitelor, hemoglobinei și hematocritului în toate loturile diabetice, cu excepția loturilor tratate cu 250 mg/kg corp metformin și 500 mg...

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Section: Fructosamine and Blood Countsupporting

confidence: 55%

Section: Fructosamine and Blood Countmentioning

confidence: 99%