Comparison of Anti-Bacterial and Anti-Inflammatory Properties of Neem, Curcumin and Aloe Vera in Conjunction with Chlorhexidine as an Intracanal Medicament – an In-Vivo Study.

Khetarpal, Samta; Bansal, Abhishek; Kukreja, Navneet

doi:10.1055/s-0038-1671999

Cited by 6 publications

(6 citation statements)

References 7 publications

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“…Curcumin's antibacterial effect as an intracanal medicament on planktonic bacteria has been shown to be significantly lower than chlorhexidine[ 28 32 ] but superior to A. vera and calcium hydroxide,[ 32 ] while in the present study conducted on biofilm state, the antibacterial activity of curcumin was equal to calcium hydroxide and superior to A. vera .…”

Section: Discussionmentioning

confidence: 54%

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The comparison of calcium hydroxide, curcumin, and Aloe vera antibacterial effects on 6-week-old Enterococcus faecalis biofilm as an intracanal medicament: An in vitro study

et al. 2022

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Background: This study aimed to compare the antibacterial effects of calcium hydroxide, curcumin, and Aloe vera as an intracanal medicament on 6-week-old Enterococcus faecalis biofilm. Materials and Methods: In this in vitro study, the solution containing E. faecalis ATCC ® 29212™ was inserted into the canals of 72 single-rooted teeth to produce biofilm. The samples were divided into four groups, and the antibacterial agent as an intracanal drug was used for 1 week. Calcium hydroxide, curcumin, and A. vera were used as intracanal medicaments in three groups, respectively, and the fourth group was irrigated with normal saline. The collected debris was cultured by spread plate method for the bacterial count by colony count machine, and the number of bacteria in each sample per ml was reported in colony-forming unit per ml (CFU/ml). The data were analyzed using SPSS software. KruskalWallis and MannWhitney U -tests were used for comparison of CFU/ml between the study groups. P <0.05 was considered significant. Results: The mean CFU/ml in the groups of calcium hydroxide, curcumin, and A. vera were 749.44, 630.55, and 1529.16, respectively. Compared with the control group, curcumin, calcium hydroxide, and A. vera showed 99.5%, 99.41%, and 98.79% antimicrobial effects, respectively. All three groups were significantly effective than the control group ( P = 0.023, P = 0.023, and P = 0.024, respectively) but were not significantly different from each other ( P = 0.057). Conclusion: All three groups showed significant antibacterial activity compared to the control group, curcumin had the most significant effect, followed by calcium hydroxide and A. vera . Therefore, herbal materials can be considered safe alternatives to synthetic medicaments for intracanal usage.

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Section: Discussionmentioning

confidence: 54%

“…[ 27 ] Due to some side effects and increased microbial resistance to calcium hydroxide, research on herbal drugs with less toxicity and fewer expenses is flourishing. [ 28 ]…”

Section: Discussionmentioning

confidence: 99%

The comparison of calcium hydroxide, curcumin, and Aloe vera antibacterial effects on 6-week-old Enterococcus faecalis biofilm as an intracanal medicament: An in vitro study

et al. 2022

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“…Khetarpal et al . (2014) stated that the presence of nimbidin and nimbolide, which are the active constituents of Neem can cause bacterial cell wall lysis. Neem also plays a role as an anti‐inflammatory agent by regulating the pro‐inflammatory enzymes such as cyclooxygenase (COX) and lipoxygenase (LOX) (Alzohairy 2016).…”

Section: Discussionmentioning

confidence: 99%

Effect of Neem (Azadirachta indica) versus 2.5% sodium hypochlorite as root canal irrigants on the intensity of post‐operative pain and the amount of endotoxins in mandibular molars with necrotic pulps: a randomized controlled trial

et al. 2021

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Aim To assess the effect of Neem versus 2.5% NaOCl as root canal irrigants on the intensity of post‐operative pain and amount of endotoxins following root canal treatment of mandibular molars with necrotic pulps. Methodology This parallel, prospective, double‐blinded, randomized controlled trial with allocation ratio 1:1 was conducted in the out‐patient clinic of the Endodontic Department, Faculty of Dentistry, Cairo University, Egypt. Fifty healthy patients with mandibular molars with necrotic pulps were randomly assigned into two equal groups using computer software. In the intervention group, root canals were irrigated using Neem; whilst 2.5% NaOCl was used in the control group. A standard root canal treatment was performed in two visits using ProTaper Next rotary files, with no intracanal medication. Pain intensity was assessed using a numerical rating scale (NRS) 6, 12, 24 and 48 h following instrumentation and canal filling. Endotoxin samples were collected using three paper points before and after canal instrumentation and a sandwich ELISA method was used to quantify the level of endotoxins. Demographic, baseline, and outcome data were collected and analysed using chi‐square tests (for the comparisons of categorical variables), Mann–Whitney tests (for non‐normally distributed variables) and Student’s t tests (for normally distributed variables), A P‐value < 0.05 was considered to be statistically significant. Results The mean pain scores within the two groups decreased continually over time. The mean pain scores in the Neem group were lower than those in the 2.5% NaOCl group at 6, 12, 24 and 48 h following instrumentation and canal filling with no significant difference between them except at 24 h following instrumentation (P = 0.012). Both irrigants significantly reduced endotoxin levels compared to the pre‐instrumentation samples (P < 0.001) by 8% for the NaOCL group and 18% for the Neem group. Conclusion Neem and 2.5% NaOCl were not significantly different in terms of reducing the intensity of post‐operative pain during all follow‐up periods except at 24 h following instrumentation where Neem was associated with lower pain intensity. Both irrigants significantly reduced endotoxin levels but were not effective in eliminating endotoxins completely from root canals of mandibular molars with necrotic pulps.

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“…32 Khetarpal et al reported that Curcuma longa showed pre-operative mean colony count of 12.55 and post operative mean colony count was 5.00 that is significant reduction of bacteria. 20 In Group II -Median colony count (CFU/ml) in Preoperative & Post-operative samples were 452 (CFU/ml) and 207 (CFU/ml) respectively. There was statistically significant reduction in the colony counts from Preoperative to Post-operative samples (P<0.01).…”

Section: Discussionmentioning

confidence: 94%

“…The antibacterial efficacy of both curcumin and aloe vera, though researched, require further studies to support their effective use as an intracanal medicaments. 20,21 Under in vivo conditions, mixed endodontic infections may show a different sensitivity or reaction towards the disinfecting agent. In vivo antibacterial studies, which combine physiological and bacteriological dynamics, have a greater clinical relevance than in vitro tests.…”

Section: Discussionmentioning

confidence: 99%

Comparative evaluation of antimicrobial efficacy of calcium hydroxide, curcumin and aloe vera as an intracanal medicament: An in-vivo study

2020

IJCE

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For achieving predictable long-term success of nonsurgical endodontic treatment, complete debridement and effective disinfection of the root canal space are considered to be essential. The use of an intracanal medication remains an important adjunct in the total elimination of bacteria remaining even after chemo-mechanical instrumentation during endodontic treatment. Calcium hydroxide is most commonly used as intracanal medicament. Herbal alternatives like turmeric, neem, aloe vera etc. have the potential to be used as intracanal medicaments. The present study was undertaken for evaluating the antimicrobial efficacy of curcumin and aloe vera as an intracanal medicament for endodontic disinfection. : In this prospective randomised controlled study, 45 patients of age group of 18-55 years requiring endodontic therapy for single rooted, single canaled teeth with periapical lesions were selected. Patients were divided into 3 groups having 15 patients each, Group I (Curcumin), Group II (Aloe vera) and Group III (Calcium hydroxide). Under aseptic conditions preoperative and post-operative samples were collected & sent to the microbiology laboratory. Antimicrobial property was assessed using the microbial colony count. : Distribution of median postoperative microbial colony counts among the cases studied did not differ significantly between Groups I and III (P-value>0.05) whereas it was significantly higher in Group II compared to Groups I and III (P-value<0.05 for both). It can be concluded that antimicrobial efficacy of curcumin showed highest antibacterial efficacy followed by calcium hydroxide and aloe vera as an intracanal medicament.

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Comparison of Anti-Bacterial and Anti-Inflammatory Properties of Neem, Curcumin and Aloe Vera in Conjunction with Chlorhexidine as an Intracanal Medicament – an In-Vivo Study.

Cited by 6 publications

References 7 publications

The comparison of calcium hydroxide, curcumin, and Aloe vera antibacterial effects on 6-week-old Enterococcus faecalis biofilm as an intracanal medicament: An in vitro study

The comparison of calcium hydroxide, curcumin, and Aloe vera antibacterial effects on 6-week-old Enterococcus faecalis biofilm as an intracanal medicament: An in vitro study

Effect of Neem (Azadirachta indica) versus 2.5% sodium hypochlorite as root canal irrigants on the intensity of post‐operative pain and the amount of endotoxins in mandibular molars with necrotic pulps: a randomized controlled trial

Comparative evaluation of antimicrobial efficacy of calcium hydroxide, curcumin and aloe vera as an intracanal medicament: An in-vivo study

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