Comparison of active constituents, antioxidant capacity, and α-glucosidase inhibition in Pluchea indica leaf extracts at different maturity stages

Vongsak, Boonyadist; Kongkiatpaiboon, Sumet; Jaisamut, Sunan; Konsap, Kanokporn

doi:10.1016/j.fbio.2018.08.006

Cited by 39 publications

(53 citation statements)

References 16 publications

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“…TPC of ethanolic extract of P. indica from Indonesia was 164.8 µg GAE/mg (Indradi et al, 2017). Several phenolic compounds were identified in P. indica leaves, such as quercetin, kaempferol, myricetin, and several caffeoylquinic derivatives (Andarwulan et al, 2010;Arsiningtyas et al, 2014;Vongsak et al, 2018). TPC of S. polyanthum obtained in this study was also different from other previous reports.…”

Section: Total Phenolic Content (Tpc)contrasting

confidence: 96%

“…The antidiabetic activity of P. indica through GIA was also previously reported. Water extract of the juvenile leaves of this plant had IC 50 of GIA 25-51 ppm, while the IC 50 of GIA at the other stages of maturity were 61-104 ppm (Vongsak et al, 2018). Guided fractionation by chromatography method was successfully identified the five caffeoylquinic acid derivatives.…”

Section: α-Glucosidase Inhibitory Activity (Gia)mentioning

confidence: 91%

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Antidiabetic activity screening and nmr profile of vegetable and spices commonly consumed in Indonesia

et al. 2021

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Apart from their nutritional value, vegetables and spices were empirically known to have functional properties such as antioxidant and antidiabetic activity. However, scientific evidence of these health effects is limited. In our effort to find potent raw material for antidiabetic functional food development, α-glucosidase inhibition and antioxidant activity of 15 Indonesian vegetables and spices methanolic extracts were screened. Their phytochemical profiles were assessed by determining total phenolic content (TPC) and 1 H NMR fingerprinting. The results showed that the Syzygium polyanthum, Pluchea indica, Etlingera elaitor, and Cosmos caudatus had the highest GIA (IC 50 11.76 ± 0.32, 12.17 ± 0.18, 53.13 ± 2.87, and 61.33 ± 1.21 μg/ml, respectively). The AA and TPC of the four samples were also higher than the others. The 1 H NMR profiles of the active samples were different from the non-active samples mainly in the aromatic region. Further observation of the spectra revealed that caffeoylquinic derivatives and esculetin were identified in P. indica; while gallic acid, syringic acid, and myricetin were identified in S. polyanthum. These compounds were known to have antidiabetic activity through different mechanisms.

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Section: Total Phenolic Content (Tpc)contrasting

confidence: 96%

Section: α-Glucosidase Inhibitory Activity (Gia)mentioning

confidence: 91%

Antidiabetic activity screening and nmr profile of vegetable and spices commonly consumed in Indonesia

et al. 2021

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“…Daun kering dan ekstrak daun beluntas di Thailand telah tersedia secara komersial sebagai teh herbal karena sifat penurun glukosa darah yang dikenal (Suriyaphan, 2014;Widyawati et al, 2015;Sirichaiwetchakoon et al, 2018). Efek antioksidan dan antidiabetes dari P. ekstrak daun indica, laporan ini sebagian besar didasarkan pada bukti aktivitas enzimatik, seperti α-glukosidase, α-amilase, dan 2, 2diphenyl-1-picryl-hydrazyl-Hydrate (dphh) tes (Noridayu et al, 2011;Arsiningtyas et al, 2014;Vongsak et al, 2018). Enam asam caffeoylquinic di P. indica daun dan berpotensi dapat diterapkan untuk digunakan dalam produk herbal komersial (Kongkiatpaiboon, Chewchinda dan Vongsak, 2018) Ekstrak daun teh daun beluntas juga memiliki kapasitas penghambatan tinggi ketika konsentrasi yang 4-16 lipat pengenceran.…”

Section: Pendahuluanunclassified

Pengamatan hasil olahan daun beluntas (Pluchea indica L.) terhadap sifat fisika dan kimianya

Donowarti

Diah²

2020

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This study was carried out to determine some bioactive phytochemicals in beluntas commonly consumed in Java, Indonesia. It is also to know the effect of fruit processing forward its phytochemicals content. This research comprised two steps including qualitative and quantitative test. The result of qualitative test showed that Pluchea indica L containing of alkaloid and polyphenols. Based on its polyphenols content, Pluchea indica L boiled was the best treatment. The light green variety has total polyphenol value 83,113 mg/g with the brightness (L*) and the greeness (a) value are 46,400 and 2,967. Furthermore, the fresh pluchea indica leaf has total polyphenol value 39,135mg/g with the brightness (L*) and the greeness (a) value are 46,067 and 2, respectively. Fruit processing intervariety of Pluchea indica L did not give significant effect on water content. Besides, variety and fruit processing did not give significant effect on colour (b). The solute n-hexane to analize with thin layer chromatography indicated that this bolied pluchea iindica leaf content terpenoid compound. Bioactive phytochemicals are widely distributed in these foods, although their concentrations are variable among the different types of fruits. These results indicate that this fruits may provide a potential source of dietary antioxidant as a functional food.

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“…Daun beluntas seperti yang terlihat pada Gambar 1 mengandung senyawa kuersetin, kaempferol, myricetin, luteolin, dan apigenin. Senyawa-senyawa tersebut tergolong ke dalam flavonoid [6,7] yang berkhasiat sebagai antibakteri. Ekstrak daun beluntas mengandung flavonoid dan memiliki aktivitas terhadap Staphylococcus aureus.…”

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“…Mekanisme flavonoid sebagai antibakteri yaitu merusak membran plasma, merubah permeabilitas dinding sel bakteri pada konsentrasi rendah, danmembunuhsel pada konsentrasi tinggi. Ekstrak daun beluntas dengan minimum inhibitory concentration (MIC) 29,4 mg/mL atau dosis 900 mg untuk volume 30 mL dapat menghambat pertumbuhan Staphylococcus aureus [8,9].…”

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Formulasi dan Evaluasi Sediaan Submikro Partikel Gelasi-Ionik Pembawa Ekstrak Daun Pluchea indica Sebagai Antibakteri pada Kulit Tikus Putih Jantan Galur Wistar

et al. 2019

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Telah dilakukan penelitian mengenai formulasi dan evaluasi sediaan submikro partikel gelasi inonik pembawa ekstrak Beluntas (Pluchea indica L) sebagai antibakteri. Penelitian ini bertujuan untuk mengetahui efektivitas anti bakteri submikro partikel terhadap Staphylococcus aureus dengan melihat penurunan jumlah dan diameter abses pada kulit tikus putih jantan galur wistar. Preparasi ekstrak daun beluntas menjadi sediaan submikro partikel menggunakan polimer kitosan dan natrium alginat serta kalsium klorida (CaCl2) sebanyak 40 mL dengan konsentrasi 18 mM sebagai crosslinker dengan metode gelasi ionik. Tiga formula (F1-F3) dibedakan atas jumlah ekstrak 450, 900, dan 1350 mg untuk masing-masing formula. Formula optimum submikro partikel yang didapatkan memiliki persen efisiensi enkapsulasi terbesar yaitu 86,742% (formula 1). Hasil karakterisasi submikro partikel seperti diameter, distribusi ukuran partikel (PDI), dan zeta potensial dengan menggunakan alat particle size analyzer pada formula optimum (F1) yaitu 529,5 nm; 0,567; dan-27,6 mV. Pengujian in vivo menggunakan 6 kelompok diantarannya: kontrol normal (tanpa perlakuan), kontrol positif (salep tetrasiklin HCl 3%), kontrol negatif (tanpa bahan uji), kelompok uji I (submikro partikel), kelompok uji II (ekstrak), dan kelompok uji III (plasebo). Kulit tikus dioleskanStaphylococcus aureus selama 3 hari untuk mengindikasikan terbentuknya abses, kemudian pemberian bahan uji terhadap masing masing kelompok diberikan selama 7 hari berikutnya..Hasil penelitian in vivo menunjukkan bahwa submikro partikel kitosan dan natrium alginat pembawa ekstrak daun beluntas pada dosis 450 mg menghasilkan penurunan diameter abses sebesar85%, sedangkan pada ekstrak murni sebesar 60%, dan salep tetrasiklin-HCl sebesar 100%.

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Comparison of active constituents, antioxidant capacity, and α-glucosidase inhibition in Pluchea indica leaf extracts at different maturity stages

Cited by 39 publications

References 16 publications

Antidiabetic activity screening and nmr profile of vegetable and spices commonly consumed in Indonesia

Antidiabetic activity screening and nmr profile of vegetable and spices commonly consumed in Indonesia

Pengamatan hasil olahan daun beluntas (Pluchea indica L.) terhadap sifat fisika dan kimianya

Formulasi dan Evaluasi Sediaan Submikro Partikel Gelasi-Ionik Pembawa Ekstrak Daun Pluchea indica Sebagai Antibakteri pada Kulit Tikus Putih Jantan Galur Wistar

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