Comparison of 15% Azelaic Acid Gel and 0.75% Metronidazole Gel for the Topical Treatment of Papulopustular Rosacea

Czernielewski, J.; Liu, Yin

doi:10.1001/archderm.140.10.1282-b

Cited by 27 publications

(31 citation statements)

References 6 publications

(3 reference statements)

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“…However, it was reported that topical azelaic acid was more effective than topical metronidazole in the treatment of papulopustular rosacea. 17,18 Fleischer and Chen 16 found that azelaic acid alone or in combination with oral antibiotics improved RosaQOL scores. However, we did not see any improvement of clinical findings, as assessed by DLQI, with the use of azelaic acid in the treatment of rosacea.…”

Section: Discussionmentioning

confidence: 99%

The impact of rosacea on quality of life: effects of demographic and clinical characteristics and various treatment modalities

Aksoy¹,

Altaykan-Hapa

Egemen

et al. 2010

British Journal of Dermatology

117

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Rosacea affects patients' lives to a moderate extent, and this can be assessed by using DLQI. DLQI is also sensitive to quality of life changes brought about by treatment of rosacea. As a preliminary result we can say that topical metronidazole, oral tetracycline and oral isotretinoin seem to improve quality of life of patients by improving lesions of rosacea more efficiently than other therapeutic agents.

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Section: Discussionmentioning

confidence: 99%

The impact of rosacea on quality of life: effects of demographic and clinical characteristics and various treatment modalities

Aksoy¹,

Altaykan-Hapa

Egemen

et al. 2010

British Journal of Dermatology

117

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“…PaGA success was defined as PaGA 'excellent' or 'good' improvement (PaGA 1-2). [30][31][32] (ii) IGA, scored on a five-point scale ranging from 'clear' to 'severe' (0-4). IGA success was defined as an IGA score of 'clear' or 'near clear' (IGA 0-1).…”

Section: Study Outcomesmentioning

confidence: 99%

DOMINO, doxycycline 40 mg vs. minocycline 100 mg in the treatment of rosacea: a randomized, single-blinded, noninferiority trial, comparing efficacy and safety

et al. 2017

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Minocycline 100 mg is noninferior to doxycycline 40 mg in efficacy over a 16- week treatment period. At follow-up, RosaQoL and PaGA were statistically significantly more improved in the minocycline group than in the doxycycline group, and minocycline 100 mg gives longer remission. In this study there was no significant difference in safety between these treatments; however, based on previous literature minocycline has a lower risk-to-benefit ratio than doxycycline. Minocycline 100 mg may be a good alternative treatment for those patients who, for any reason, are unable or unwilling to take doxycycline 40 mg.

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“…The study variables and scales have been published previously and have been shown to be reliable and reproducible. 7 At baseline and at each follow-up visit (weeks 4, 8 and 12), the investigator performed a manual count of the total number of inflammatory lesions (pustules and papules) on the entire face. At each visit, the investigator: (i) rated the severity of erythema and telangiectasia, each on a 4-point scale;…”

Section: Reportmentioning

confidence: 99%

“…(ii) provided a descriptive score for the global assessment of disease severity, which integrates the overall severity of symptoms, inflammatory lesions, erythema and telangiectasia using a 7-point static scoring system; 7 and (iii) rated the overall improvement compared with baseline using a 6-point scale. At each visit, photodamage as assessed by fine wrinkles, texture, mottled hyperpigmentation on a four-point scale was also assessed by the investigator.…”

Section: Reportmentioning

confidence: 99%

Topical kinetin 0.1% lotion for improving the signs and symptoms of rosacea

Wu¹,

Weinstein²,

Kricorian³

et al. 2007

Clin Exp Dermatol

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Many patients with rosacea are unable to tolerate extended treatment periods with topical agents because of the unusually high skin sensitivity that often accompanies rosacea. Kinetin (N(6)-furfuryladenine) is a plant cytokinin that reportedly helps restore skin barrier function and may be useful to ameliorate the signs and symptoms of rosacea. The purpose of this open-label study was to determine the tolerance and efficacy of twice-daily application of kinetin 0.1% lotion for improving the signs and symptoms of mild to moderate facial rosacea. Subjects applied kinetin 0.1% lotion twice daily to the face, with daily use of a sunscreen of sun protection factor 30. Subjects were evaluated at baseline and at 4-week intervals for 12 weeks to assess efficacy and tolerance. Results of this study suggest that kinetin 0.1% lotion is a well-tolerated moisturizing lotion option for subjects with mild to moderate inflammatory rosacea.

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Comparison of 15% Azelaic Acid Gel and 0.75% Metronidazole Gel for the Topical Treatment of Papulopustular Rosacea

Cited by 27 publications

References 6 publications

The impact of rosacea on quality of life: effects of demographic and clinical characteristics and various treatment modalities

The impact of rosacea on quality of life: effects of demographic and clinical characteristics and various treatment modalities

DOMINO, doxycycline 40 mg vs. minocycline 100 mg in the treatment of rosacea: a randomized, single-blinded, noninferiority trial, comparing efficacy and safety

Topical kinetin 0.1% lotion for improving the signs and symptoms of rosacea

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