Comparison between the effects of selenomethionine and S-adenosylmethionine in preventing cholestasis-induced rat liver damage

Brzački, Vesna; Mladenović, Bojan; Dimic, Dragan; Jeremić, Ljiljana; Živanović, Dragoljub; Djukic, D; Stojanović, Nikola; Sokolović, Dušan

doi:10.1007/s00726-019-02716-3

Cited by 17 publications

(6 citation statements)

References 32 publications

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“…SeMet supplementation significantly reduced aortic atherosclerotic plaque formation, improved vessel function, and decreased the inflammatory response in high fat diet fed apolipoprotein E deficient (ApoE –/– ) mice, highlighting the potential of SeMet supplementation in atherosclerosis therapy (Zhang et al., 2020). SeMet acted as an antioxidant to prevent cholestasis‐induced liver damage and inflammation (Brzački et al., 2019), and it also alleviated T‐2 toxin (type A trichothecenes)‐induced oxidative stress, inflammatory response, intestinal barrier damage, and kidney injury (Liu, Dong, et al., 2020; Liu, Yang, et al., 2020). SeMet and selenite both reduced 3,5‐dimethylaminophenol‐induced oxidative stress, DNA damage, and apoptosis in human urothelial cells, and SeMet at a concentration of 10 μmol/L exerted protecting effect equal to that of selenite at a concentration of 30 μmol/L (Erkekoglu et al., 2019).…”

Section: Selenium Species In Cereals and Human Healthmentioning

confidence: 99%

Selenium in cereals: Insight into species of the element from total amount

Xie

Sun

et al. 2021

Comp Rev Food Sci Food Safe

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Selenium (Se) is a trace mineral micronutrient essential for human health. The diet is the main source of Se intake. Se‐deficiency is associated with many diseases, and up to 1 billion people suffer from Se‐deficiency worldwide. Cereals are considered a good choice for Se intake due to their daily consumption as staple foods. Much attention has been paid to the contents of Se in cereals and other foods. Se‐enriched cereals are produced by biofortification. Notably, the gap between the nutritional and toxic levels of Se is fairly narrow. The chemical structures of Se compounds, rather than their total contents, contribute to the bioavailability, bioactivity, and toxicity of Se. Organic Se species show better bioavailability, higher nutritional value, and less toxicity than inorganic species. In this paper, we reviewed the total content of Se in cereals, Se speciation methods, and the biological effects of Se species on human health. Selenomethionine (SeMet) is generally the most prevalent and important Se species in cereal grains. In conclusion, Se species should be considered in addition to the total Se content when evaluating the nutritional and toxic values of foods such as cereals.

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Section: Selenium Species In Cereals and Human Healthmentioning

confidence: 99%

Selenium in cereals: Insight into species of the element from total amount

Xie

Sun

et al. 2021

Comp Rev Food Sci Food Safe

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“…One of the tissue oxidative parameters determined in this study is XO activity. This enzyme is responsible for the majority of Reactive Oxygen Species (ROS) production and its products are known to cause the disturbance in hepatic antioxidative capacities [26] . Hence, it would be advantageous to have a drug with the ability to inhibit XO, apart from acting on some other targets.…”

Section: Resultsmentioning

confidence: 99%

“…The XO activity was determined by measuring the absorption spectrophotometrically, at 293 nm. The enzyme activity was expressed as U/g tissue protein of liver homogenate, using a molar coefficient of 7.6×10 -3 and expressed as U/mg proteins [26] .…”

Section: Determination Of Xanthine Oxidase (Xo) Activitymentioning

confidence: 99%

Hepatoprotective Potential of Lycopene in a Rat Model of Cisplatin-Induced Damage: Involvement of Oxidative Cell Damage and Glutathione Metabolism

Mladenovic¹,

Mihajlovic²,

Nickovic³

et al. 2022

IJPS

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Mladenovic et al.: Hepatoprotective Potential of LycopeneApplication of cisplatin for the treatment of various solid tumors is known to cause liver damage, through an increase in lipid peroxidation and reactive oxygen species production. Lycopene is a powerful antioxidant agent capable of preventing the cells damage, the formation of stronger intercellular bonds and faster cellular metabolism. This study aims to estimate the potential of lycopene in preventing cisplatin induced liver tissue damage by studying the levels of several biochemical parameters (arginase, aminotransferases, alkaline phosphatase, gamma-glutamyl transpeptidase activity, total protein and albumin concentration) reflecting liver function and a panel of liver tissue biomarkers (xanthine oxidase, reduced glutathione, malondialdehyde, protein carbonylated concentration and diamino oxidase activity). These parameters would be studied in male Wistar rats treated with either cisplatin alone or with cisplatin and lycopene. Additionally, microscopic analysis of liver tissue would be conducted as well. Application of the combination of lycopene and cisplatin significantly prevented the disturbance in all here-studied biomarkers of liver tissue damage. Morphological liver tissue alterations followed the changes in hepatic biochemical status. Our results suggest that lycopene could act as a protective agent in cisplatin-induced liver damage in rats.

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“…SAMe is also frequently applied in other types of cholestatic disease, including neonatal cholestasis and cholestasis caused by NAFLD ( Virukalpattigopalratnam et al, 2013 ; Zeng et al, 2021 ). Evidence from both animal models and clinical trials revealed that exogenous administration of SAMe raised the GSH levels and ameliorated liver injuries ( Mora et al, 2018 ; Brzački et al, 2019 ). In spite of its widely accepted therapeutic effects, the exact kernel mechanism of its function remains to be explored since SAMe is involved in so many critical cellular processes.…”

Section: Hepatoprotective Agents In the Management Of Icpmentioning

confidence: 99%

Hepatoprotective agents in the management of intrahepatic cholestasis of pregnancy: current knowledge and prospects

Shan,

Dai,

Chen

et al. 2023

Front. Pharmacol.

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Intrahepatic cholestasis of pregnancy (ICP) is characterized by unexplained distressing pruritus in the mother and poses significant risk to the fetus of perinatal mortality. Occurring in the second and third trimester, the serum bile acid and aminotransferase are usually elevated in ICP patients. Ursodeoxycholic acid (UDCA) is the first line drug for ICP but the effectiveness for hepatoprotection is to a certain extent. In ICP patients with severe liver damage, combination use of hepatoprotective agents with UDCA is not uncommon. Herein, we reviewed the current clinical evidence on application of hepatoprotective agents in ICP patients. The underlying physiological mechanisms and their therapeutic effect in clinical practice are summarized. The basic pharmacologic functions of these hepatoprotective medications include detoxification, anti-inflammation, antioxidation and hepatocyte membrane protection. These hepatoprotective agents have versatile therapeutic effects including anti-inflammation, antioxidative stress, elimination of free radicals, anti-steatohepatitis, anti-fibrosis and anti-cirrhosis. They are widely used in hepatitis, non-alcoholic fatty liver disease, drug induced liver injury and cholestasis. Evidence from limited clinical data in ICP patients demonstrate reliable effectiveness and safety of these medications. Currently there is still no consensus on the application of hepatoprotective agents in ICP pregnancies. Dynamic monitoring of liver biochemical parameters and fetal condition is still the key recommendation in the management of ICP pregnancies.

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Comparison between the effects of selenomethionine and S-adenosylmethionine in preventing cholestasis-induced rat liver damage

Cited by 17 publications

References 32 publications

Selenium in cereals: Insight into species of the element from total amount

Selenium in cereals: Insight into species of the element from total amount

Hepatoprotective Potential of Lycopene in a Rat Model of Cisplatin-Induced Damage: Involvement of Oxidative Cell Damage and Glutathione Metabolism

Hepatoprotective agents in the management of intrahepatic cholestasis of pregnancy: current knowledge and prospects

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