Comparison Between Serum α-Glutathione S-Transferase and Aminotransaminases in Detecting Cytolysis in Hepatitis C-Infected Children

Namour, Farès; Morali, A.; Ilardo, Claudio; Abballe, Xavier; Maury, Florence; Guéant, Jean‐Louis

doi:10.1097/00005176-199905000-00019

Cited by 5 publications

(2 citation statements)

References 24 publications

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“…Nevertheless, this may need a sensitive and accurate parameter for early detection of liver damage. Although assessment of plasma level of alanine aminotransferase (ALT) is known to be the most specific parameter for hepatocellular damage, it is found to be elevated only in 40.2% of HCV seropositive patients [3] and 54.4% of HCV RNA positive patients [4]. Moreover, aminotransferase levels in those patients do not reflect HCV-RNA levels [5, 6].…”

Section: Introductionmentioning

confidence: 99%

“…Namour et al showed low sensitivity of α-GST for cytolysis of hepatocytes [4], while Federico et al and Helaly and Mahmoud described α-GST as a more useful marker than other biochemical parameters in assessment of hepatocellular damage in this condition [7, 9]. Consequently, our study was planned to investigate the significance of assessment of α-GST plasma levels in HCV infection with different ALT patterns and its relation to viremia and other biochemical parameters of hepatocellular damage.…”

Section: Introductionmentioning

confidence: 99%

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Significance of Serum Alpha-Glutathione S-Transferase Assessment in Hepatitis C Patients with Different Alanine Aminotransferase Patterns

Abdel-Moneim

Sliem

2011

Gastroenterol Res

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BackgroundAlpha-Glutathione S-transferase (α-GST) is a liver enzyme which showed properties making it useful in assessment of liver cell damage. A number of studies demonstrated its early elevation in different hepatic insults, but its pattern in HCV was controversial. Consequently, we planned this work to study the significance of Serum Alpha-Glutathione S-Transferase (α-GST) assessment in hepatitis C patients with different alanine aminotransferase (ALT) patterns.MethodsSixty-five untreated male patients with history of hepatitis C virus (HCV) positive antibodies and 21 healthy age- and sex-matched control subjects were enrolled in this study. Sera were collected for confirmation of the presence of HCV antibodies (by ELISA) as well as for assessment of the levels of α-GST, ALT, aspartate aminotransferase, alkaline phosphatase, gamma glutamyl-transferase, total proteins, albumin and HCV RNA. HCV RNA was detected by the reverse transcription polymerase chain reaction (RT-PCR). Based on ALT level, patients were divided into three groups. Twelve patients with normal ALT levels (NALT), 29 with near normal ALT levels (NNALT), and 24 with high ALT levels (HALT). All data were statistically analyzed for significance and correlation as well as sensitivity, specificity, positive and negative predictive values.ResultsThe mean value of α-GST in HCV patients was significantly higher compared to the control with 82% sensitivity, 85% specificity, 98% positive predictive value and 63% negative predictive value. These results were more or less similar to the results of ALT and higher than the results of all the other assayed liver function tests. The sensitivity, and positive and negative predictive values of α-GST were lower than aminotransferases, but higher than the other assayed liver function tests in NNALT and HALT groups. Nevertheless, in NALT, these parameters were higher for α-GST than all the other assayed liver function tests including aminotransferases.ConclusionsAssay of α-GST has an adjuvant in evaluation of liver cell damage in HCV patients. However, its role is much more valuable in patients with normal aminotransferases for early detection of liver cell damage.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Significance of Serum Alpha-Glutathione S-Transferase Assessment in Hepatitis C Patients with Different Alanine Aminotransferase Patterns

Abdel-Moneim

Sliem

2011

Gastroenterol Res

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Serum retinol binding protein 4 and nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus

Wu¹,

Wang²,

Bao³

et al. 2008

Diabetes Research and Clinical Practice

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Glutathione-S-transferase genetic polymorphism and risk of hepatotoxicity to antitubercular drugs in a North-African population: A case-control study

Chbili

Fathallah

Laadhari

et al. 2022

Gene

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Comparison Between Serum α-Glutathione S-Transferase and Aminotransaminases in Detecting Cytolysis in Hepatitis C-Infected Children

Abstract: The combination of ALT with AST is actually the best compromise in detecting cytolysis in untreated HCV-infected patients.

Cited by 5 publications

References 24 publications

Significance of Serum Alpha-Glutathione S-Transferase Assessment in Hepatitis C Patients with Different Alanine Aminotransferase Patterns

Significance of Serum Alpha-Glutathione S-Transferase Assessment in Hepatitis C Patients with Different Alanine Aminotransferase Patterns

Serum retinol binding protein 4 and nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus

Glutathione-S-transferase genetic polymorphism and risk of hepatotoxicity to antitubercular drugs in a North-African population: A case-control study

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