Comparison between HELLP syndrome, chronic hypertension, and superimposed preeclampsia on chronic hypertension without HELLP syndrome

Osmanağaoğlu, Mehmet A.; ERDOĞAN, İbrahim Ethem; Zengin, Ülkü; Bozkaya, Hasan

doi:10.1515/jpm.2004.132

Cited by 24 publications

(24 citation statements)

References 12 publications

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“…Some studies have shown that perinatal morbidity was higher in patients with HELLP syndrome than in those with hypertension alone (15,16). However, there are further studies showing that gestational age was more effective than maternal disease for perinatal outcomes (7,(17)(18)(19). In two studies, neonatal death rates were not different between HELLP syndrome and severe preeclampsia at the same stage of gestation (7,20).…”

Section: Discussionmentioning

confidence: 99%

Severe Preeclampsia versus HELLP Syndrome: Maternal and Perinatal Outcomes at <34 and ≥34 Weeks’ Gestation

Kinay¹,

Kucuk²,

Kayıkçıoğlu³

et al. 2015

Balkan Med J

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Background: Preeclampsia and Hemolysis, Elevated Liver enzymes, Low Platelet (HELLP) syndrome are important disorders affecting the health of both the mother and fetus. Prediction of the maternal and perinatal outcomes at early and late gestational age is important for the management of both disorders. Aims: The purpose of the study was to investigate adverse maternal and perinatal outcomes in severe preeclampsia and HELLP syndrome cases according to gestational age. Study Design: Retrospective cross-sectional study. Methods: One hundred and ninety-seven pregnancies with severe preeclampsia and 56 pregnancies with HELLP syndrome were included the study. Clinical characteristics and adverse maternal and perinatal outcomes were noted from medical records. Participants were divided into two groups at <34 and ≥34 weeks' gestation: the severe preeclampsia group and the HELLP syndrome group. The differences between the outcomes in the groups were investigated. Statistical analysis was performed using the Student t test, Fisher Exact test and Yates' Chi-square test. Results: Eclampsia was more common in HELLP syndrome cases at <34 weeks' gestation (p 0.028). However, eclampsia rates were statistically similar between groups at ≥34 weeks' gestation. The requirement for blood products transfusion was higher in the HELLP group at all gestational weeks. No statistical difference was found in perinatal outcomes between severe preeclampsia and HELLP groups at less than and more than 34 weeks' gestation. Conclusion: Eclampsia risk increases in HELLP syndrome, especially at gestations less than 34 weeks. Perinatal morbidity at less than 34 weeks' gestation and mortality were similar in severe preeclampsia and HELLP syndrome cases at the same gestational age.

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Section: Discussionmentioning

confidence: 99%

Severe Preeclampsia versus HELLP Syndrome: Maternal and Perinatal Outcomes at <34 and ≥34 Weeks’ Gestation

Kinay¹,

Kucuk²,

Kayıkçıoğlu³

et al. 2015

Balkan Med J

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“…As Tabelas 1 e 2 apresentam estudos realizados com mulheres que desenvolveram pré-eclâmpsia sobreposta à hipertensão crônica. Tiveram agravos no resultado materno e perinatal 20% a 78%, incluindo restrição do crescimento fetal (8,5% a 30,7%), prematuridade (32,4% a 86,4%), parto cesarea (69,2%), descolamento prematuro da placenta (3,75% a 8,4%), óbito fetal (9,5% a 27,2%) e complicações cardíacas, vasculares, renais e pulmonares maternas (5)(6)(7)(8)10,16,(22)(23)26,28) . Em alguns trabalhos o número de hipertensas foi pequeno, sugestivo a critério diagnóstico de hipertensão crônica tabela 1 -Número de mulheres estudadas durante os anos de 1990 a 1999 e a ocorrência de complicações.…”

Section: Resultsunclassified

“…Este tipo de hipertensão pode ser primá-ria ou essencial, esta representada por 90% dos casos e secundária, incluindo desordens renovasculares, coarctação da aorta, distúrbios endócrinos e doenças vasculares do colágeno (3,(7)(8) .…”

Section: Introductionunclassified

Resultado perinatal em mulheres portadoras de hipertensão arterial crônica: revisão integrativa da literatura

Henrique

Borrozzino²,

Gabrielloni

et al. 2012

Rev. Bras. Enferm.

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ReSUmOObjetivou-se identificar as principais complicações relativas à Hipertensão Arterial Crônica observadas em mulheres gestantes e conhecer a evolução nos padrões de riscos dos resultados perinatais em duas décadas. Realizou-se uma revisão integrativa da literatura com abrangência temporal entre os anos de 1990 e 2010, nas bases de dados LILACS, SciELO e MEDLINE. Entre os resultados, observou-se que gestantes hipertensas crônicas apresentaram pré-eclâmpsia sobreposta (20% a 78%), restrição do crescimento fetal (8,5% a 30,7%), prematuridade (32,4% a 86,4%), cesárea (69,2%), descolamento prematuro da placenta (3,75% a 8,4%), óbito fetal (9,5% a 27,2%), complicações cardiovasculares, renais e pulmonares maternas. Conclui-se que a associação entre hipertensão crônica e gestação mostra forte risco para complicações maternas e perinatais, principalmente quando associados à severidade e etiologia da hipertensão, não mostrando evolução no decorrer das duas décadas pesquisadas sobre o resultado perinatal. descritores: Hipertensão Arterial; Gestação; Doença Crônica; Complicações na Gravidez. aBStRaCtThe study aimed to identify patterns in the evolution of risk of perinatal outcomes of pregnant women with chronic hypertension in order to compare the results of the pregnancy outcome. It was held an integrative literature with time span between the years 1990 and 2010, in the databases LILACS, SciELO and MEDLINE. As results, it was observed that pregnant women had chronic hypertensive superimposed preeclampsia (20% to 78%), fetal growth restriction (8.5% to 30.7%), prematurity (32.4% to 86.4%), cesarean section (69 2%), placental abruption (3.75% to 8.4%), fetal death (9.5% to 27.2%), cardiovascular complications, maternal kidney and lung. We conclude that the association of chronic hypertension and pregnancy shows strong risk for maternal and perinatal complications, especially when associated with the severity and etiology of hypertension, showing no trend during the two decades studied on perinatal outcome. Key words: Hypertension; Pregnancy; Chronic Disease; Pregnancy Complications. ReSUmeNObjetivó-se identificar los patrones en la evolución del riesgo de resultados perinatales de las mujeres embarazadas con hipertensión crónica con el fin de comparar los resultados de la evolución del embarazo. Realizó-se una revisión integradora de la literatura, con lapso de tiempo entre los años 1990 y 2010, en las databases LILACS, SciELO y MEDLINE. En los resultados, fue observado que las mujeres embarazadas con hipertensión crónica apresentaran preeclampsia superpuesta (20% a 78%), restricción del crecimiento fetal (8,5% a 30,7%), prematuridad (32,4% a 86,4%), cesárea (69 2%), desprendimiento abrupto de la placenta (3,75% a 8,4%), muerte fetal (9,5% a 27,2%), complicaciones cardiovasculares, renales y pulmonares materna. Concluye-se que la asociación de hipertensión crónica y embarazo presenta riesgo importante para complicaciones maternas y perinatales, especialmente cuando se asocia con la gravedad y etiología de la hipertens...

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“…If the maternal conditions alter, caesarean section is inevitable (1,31,32,33). Some authors warn against conservative management and contraindicate it (34).…”

Section: Management Of Hellpmentioning

confidence: 99%

Postpartum corticosteroids in HELLP syndrome – standard to prompt recovery

Gábor¹,

Drab²,

Holomán³

2016

BLL

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OBJECTIVES: To perform a complex review of HELLP syndrome and its treatment from up to date scientifi c literature. Study of the interresting treatement regime of the patient. METHODS: Complex analysis of the syndrome, systematic search of medical scientifi c databases and Slovak Medical Library. Analysis of the life threatening state of the patient, retrospective analysis of the diagnostics, treatment, acute management, complications and clinical results. RESULTS: According to up to date literature and our good clinical experiences we can encourage the use of high-dose corticosteroid therapy in HELLP syndrome. CONCLUSION: The most recent studies defi nitely recommend the high dose corticosteroid treatment in recovery management by the HELLP syndrome. We have used the high-dose corticosteroid regime as a recovery management for the patient with postpartum HELLP with very good clinical and laboratory response followed by prompt recovery of the patient and without other complications. We want to support and empasize the indication of the Dexamethasone regiment by HELLP, becouse the clinical experiences with this treatment are not well-known and usually the corticosteroids are not given to the patients with HELLP, or the treatment is "daemonized". Our clinical experience with this treatment was successful and the patient defi nitely profi ted of it. We support the opinion, that the benefi t of described regiment highly exceedes the possible adverse effects of the therapy (Fig. 8, Ref. 61). Text in PDF www.elis.sk.

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Comparison between HELLP syndrome, chronic hypertension, and superimposed preeclampsia on chronic hypertension without HELLP syndrome

Abstract: Perinatal outcome is primarily influenced by gestational age at delivery and birthweight independent of the severity of the hypertensive status of pregnant women.

Cited by 24 publications

References 12 publications

Severe Preeclampsia versus HELLP Syndrome: Maternal and Perinatal Outcomes at <34 and ≥34 Weeks’ Gestation

Severe Preeclampsia versus HELLP Syndrome: Maternal and Perinatal Outcomes at <34 and ≥34 Weeks’ Gestation

Resultado perinatal em mulheres portadoras de hipertensão arterial crônica: revisão integrativa da literatura

Postpartum corticosteroids in HELLP syndrome – standard to prompt recovery

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