Comparison between familial and nonfamilial melanoma in France

Breslow depth of cutaneous melanoma: Impact of factors related to surveillance of the skin, including prior skin biopsies and family history of melanoma

“…Although, as observed in previous series, 46 familial patients were more likely than sporadic patients to have multiple clinically atypical nevi, they did not have more skin biopsies of any type of lesion performed in the 5 years before the diagnosis of their first melanoma than did sporadic patients (see Table III). In contrast, familial patients were more likely than sporadic patients to have had more than 2 biopsies of atypical nevi during the 5 years after the initial diagnosis of melanoma.…”

“…Several (including this study) found no association, 24,45,46 whereas others showed significantly thinner mean Breslow depths 27,47 or likelihood of lesions 0.75 mm or less in depth 37 in patients who reported a family history of melanoma. Because verification of the family histories (as was done in our study) was only performed in one of these series, 46 and other studies have demonstrated false-positive-reporting rates of up to 50%, 48,49 it is possible that confounding factors (eg, level of concern leading to skin examination) associated with the false belief of a family history of melanoma may have influenced the outcomes.…”

Acral lentiginous melanoma presents distinct clinical profile with high cancer susceptibility

“…: no statistically significant non-cutaneous neoplasias, but they did not compare them with those of the remaining melanoma patients or the general population [17]. They also found 3% of patients with multiple melanomas and 5% with family history of melanoma [17], slightly lower figures than those previously reported in the literature for the same population [25]. Our data thus support the probability that ALM might appear in a certain cancer susceptibility setting but related to genes other than those associated with melanoma prone families.…”

Increased cancer risk for individuals with a family history of prostate cancer, colorectal cancer, and melanoma and their associated screening recommendations and practices

“…Currently, it is estimated that one in 59 men and women will be diagnosed with melanoma during their lifetime [3]. Although at least 90% of melanomas occur sporadically, the other 5-10% that occur within families represent an important risk factor for the disease [130]. Hemminki et al calculated the PAF to be 1.43% [1].…”