Comparison Between Cardiac Output Measured by the Pulmonary Arterial Thermodilution Technique and that Measured by the Femoral Arterial Thermodilution Technique in a Pediatric Animal Model

Abstract

This study compares the correlation between two methods for the determination of cardiac output-the pulmonary arterial thermodilution technique using the Swan-Ganz catheter and the femoral arterial thermodilution technique using a pulse contour analysis computer (PiCCO) catheter. We performed a prospective animal study using 16 immature Maryland pigs weighing 9 to 16 kg. A 5.5- or 7.5-Fr Swan-Ganz catheter was introduced into the femoral or jugular vein, and a 4- or 5-Fr arterial PiCCO catheter was introduced into the femoral artery. In each animal, we made measurements of cardiac output at 30-minute intervals, simultaneously by pulmonary arterial thermodilution and femoral arterial thermodilution, before, during, and after hemodiafiltration carried out via different venous catheters, recording a total of 78 measurements. The mean Swan-Ganz cardiac output was 2.22 +/- 0.94 L/min, and mean PiCCO cardiac output was 1.94 +/- 0.80 L/min (no significant difference). The mean difference (bias) of differences (limits of agreement) was 0.2812. The differences between the methods increased with higher cardiac output, but the percentage differences in relation to cardiac output remained stable. Good correlation was found between the two methods: single-measure intraclass correlation was 0.8892 (95% confidence interval, 0.54-0.95). There were no differences between the 5.5- and 7.5-FR Swan-Ganz catheters or between the 4- and 5-Fr PiCCO catheters. Femoral arterial thermodilution cardiac output measurements correlated well with pulmonary arterial thermodilution cardiac output measurements in a pediatric animal model.

Correlations between hemodynamic, oxygenation and tissue perfusion parameters during asphyxial cardiac arrest and resuscitation in a pediatric animal model

“…Other less invasive methods like PiCCO could be useful to measure cardiac output and at the same time to estimate the circulating volume. [17][18][19] In this sense, the correlation found between CI and ITBI could suggest the CI dependence of an adequate volume status during asphyxia, CPR and ROSC. However, and due to the fact that PiCCO system measures ITBI and CI by the same thermodilution method, some link between both measurement cannot be discarded.…”

Hemodynamic, respiratory, and perfusion parameters during asphyxia, resuscitation, and post-resuscitation in a pediatric model of cardiac arrest

“…Femoral arterial thermodilution measurement has been used in infantile animal models and in children [17][18][19][20][21][22][23][24]; it has showed an acceptable correlation with pulmonary arterial thermodilution by using a Swan-Ganz catheter [19,23], and therefore it might be a reliable and less invasive hemodynamic monitoring tool in the post-CA period in children.…”

Severe ischemia of the lower limb and of the intestine associated with systemic vasoconstrictor therapy and femoral arterial catheterization

“…This technique may be used in children of any age, including neonates (3,4). A number of studies have shown that a good correlation exists between the output measured by pulmonary artery and femoral artery thermodilution (3)(4)(5).…”