Comparing the DePaul Symptom Questionnaire with physician assessments: a preliminary study

Strand, Elin Bolle; Lillestøl, Kristine; Jason, Leonard A.; Tveito, Kari; Diep, Lien My; Valla, Simen Strand; Sunnquist, Madison; Helland, Ingrid B.; Herder, Ingrid; Dammen, Toril

doi:10.1080/21641846.2015.1126026

Cited by 22 publications

(19 citation statements)

References 25 publications

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“…[8,19,20,21,22] In the present study, it was found that Role-Physical and Social Functioning were significantly correlated to both the current hours and percent reduction in hours spent on different activities. These findings demonstrate that as current hours decrease and percent reduction in hours increases, the scores on the Role-Physical and Social Functioning scales will decrease, indicating worse functioning.…”

Section: Discussionmentioning

confidence: 63%

Assessing current functioning as a measure of significant reduction in activity level

Thorpe

McManimen

Gleason

et al. 2016

Fatigue: Biomedicine, Health & Behavior

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Background-Myalgic encephalomyelitis (ME) and chronic fatigue syndrome (CFS) have case definitions with varying criteria, but almost all criteria require an individual to have a substantial reduction in activity level. Unfortunately, a consensus has not been reached regarding what constitutes substantial reductions. One measure that has been used to measure substantial reduction is the Medical Outcomes Study Short Form-36 Health Survey (SF-36). [1]

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Section: Discussionmentioning

confidence: 63%

Assessing current functioning as a measure of significant reduction in activity level

Thorpe

McManimen

Gleason

et al. 2016

Fatigue: Biomedicine, Health & Behavior

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“…The categories applied in this study were gender, age at diagnosis, initiating events, disease duration and severity, comorbidities and family history. Most of the questions were based on the DePaul Symptom Questionnaire 49,50 . Infection or vaccination as initiating event was self-reported, and in many cases, the time from event to symptom debut was not specified.…”

Section: Methodsmentioning

confidence: 99%

Human Leukocyte Antigen alleles associated with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)

Lande

Fluge

Strand

et al. 2020

Sci Rep

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the etiology and pathogenesis of Myalgic encephalomyelitis/chronic fatigue Syndrome (Me/cfS) are unknown, and autoimmunity is one of many proposed underlying mechanisms. Human Leukocyte Antigen (HLA) associations are hallmarks of autoimmune disease, and have not been thoroughly investigated in a large ME/CFS patient cohort. We performed high resolution HLA -A, -B, -C, -DRB1, -DQB1 and -DPB1 genotyping by next generation sequencing in 426 adult, Norwegian ME/CFS patients, diagnosed according to the Canadian Consensus Criteria. HLA associations were assessed by comparing to 4511 healthy and ethnically matched controls. Clinical information was collected through questionnaires completed by patients or relatives. We discovered two independent HLA associations, tagged by the alleles HLA-C*07:04 (OR 2.1 [95% CI 1.4-3.1]) and HLA-DQB1*03:03 (OR 1.5 [95% CI 1.1-2.0]). These alleles were carried by 7.7% and 12.7% of ME/CFS patients, respectively. The proportion of individuals carrying one or both of these alleles was 19.2% in the patient group and 12.2% in the control group (OR 1.7 [95% CI 1.3-2.2], p nc = 0.00003). ME/CFS is a complex disease, potentially with a substantial heterogeneity. We report novel HLA associations pointing toward the involvement of the immune system in ME/CFS pathogenesis.Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a disabling disorder characterized by medically unexplained fatigue, post-exertional malaise and a variety of additional symptoms, such as chronic pain, sleep disturbances and cognitive difficulties. ME/CFS is diagnosed on clinical grounds alone, and different sets of criteria specify the mandatory symptoms as well as recommendations for the exclusion of differential diagnoses 1-3 . The specificity and validity of different diagnostic criteria have been questioned, yet there is no agreement on the level of heterogeneity in ME/CFS, and there is no consensus on how to categorize different subgroups 4-8 .The pathogenesis and etiology of ME/CFS are unknown, with several models having been proposed 9 . One central hypothesis states that autoimmunity is part of the pathophysiology 10,11 . ME/CFS has been reported to be partly heritable 12,13 , consistent with a multifactorial etiology dependent on both genetic and environmental factors. This is the prevailing model for a vast number of diseases, including established autoimmune diseases (AID). Several publications report immunological alterations among ME/CFS patients, e.g. changes in natural killer (NK) cell function 14,15 , cytokine levels 16,17 , and DNA methylation patterns consistent with immune dysregulation 18 . Some of these findings have failed to reproduce in other studies, which could be due to differences in methodology, the complexity and heterogeneity of ME/CFS, and lack of power due to small sample sizes 19 . Resultingly, the autoimmunity hypothesis warrants further evaluation. A characteristic feature of AID is genetic association with certain human leukocyte antigen (HLA) alleles 20 . Thus, a thorough inve...

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“…The DSQ is a standardized, self-report questionnaire that assesses onset, frequency, and severity of symptoms related to CFS, as well as levels of physical and social functioning. 16,17 The DSQ asks about 54 symptoms for which the respondent rates the frequency and severity of each symptom during the past 6 months. Responses are on a 5-point Likert scale for frequency (0 indicating none of the time; 1, a little of the time; 2, approximately half the time; 3, most of the time; and 4, all the time) and severity (0indicating symptom not present; 1, mild; 2, moderate; 3, severe; and 4, very severe).…”

Section: Instruments and Measures Usedmentioning

confidence: 99%

Associations Between Autonomic and Orthostatic Self-report and Physician Ratings of Orthostatic Intolerance in Youth

Schultz

Katz

Bockian

et al. 2019

Clinical Therapeutics

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Purpose: There is no known biological marker or physical assessment to diagnose chronic fatigue syndrome (CFS), leaving physicians to heavily rely on self-report measures regarding the symptoms associated with CFS. Common symptoms of CFS include difficulty sleeping, joint pain, headaches, sore throat, cognitive dysfunction, physical exhaustion, dizziness, and nausea. Because of the overlap among CFS symptoms and autonomic functioning, we examined the association between 2 self-report measures of orthostatic and autonomic symptoms and a physician's report of autonomic functioning (measures of changes in blood pressure and pulse) to further understand the association among autonomic functioning within individuals with symptoms of CFS. Methods: With data from an ongoing study, we used independent t tests and Pearson correlation tests to assess the association among the orthostatic domain from the DePaul Symptom Questionnaire, Autonomic Symptom Checklist composite scores, and the physician's assessment of orthostatic intolerance obtained from a sample of 191 participants, 42 who were healthy controls. Findings: No significant demographic differences were found between the CFS-like group and the healthy controls. Results indicate a significant correlation between orthostatic and autonomic functioning (r ¼ 0.58) and a correlation with a low effect size among autonomic functioning and physician measures of orthostatic functioning (r ¼ −0.01 to 0.29). However, fewer correlations were found between self-reported symptoms of orthostatic functioning and the physician's measures of orthostatic functioning. Implications: These results suggest that although orthostatic dysfunction is reported in children and adolescents with CFS-like symptoms, the physical measures of autonomic functioning in this study were unable to detect these symptoms. (Clin Ther.

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Comparing the DePaul Symptom Questionnaire with physician assessments: a preliminary study

Cited by 22 publications

References 25 publications

Assessing current functioning as a measure of significant reduction in activity level

Assessing current functioning as a measure of significant reduction in activity level

Human Leukocyte Antigen alleles associated with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)

Associations Between Autonomic and Orthostatic Self-report and Physician Ratings of Orthostatic Intolerance in Youth

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