Comparing plasma concentrations of persistent organic pollutants and metals in primiparous women from northern and southern Canada

Curren, Meredith S.; Davis, Karelyn; Liang, Chun Lei; Adlard, Bryan; Foster, Warren G.; Donaldson, Shawn G.; Kandola, Kami; Brewster, Janet; Potyrala, Mary; Oostdam, Jay Van

doi:10.1016/j.scitotenv.2014.01.017

Cited by 27 publications

(23 citation statements)

References 42 publications

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“…Studies have found high levels of mercury and POPs in indigenous peoples of the North American Arctic, where subsistence food chains are the primary source of exposure to environmental contaminants. High levels of PCBs have been documented among Inuit peoples of Arctic North America, with highest levels among island and coastal communities for whom marine mammals and fish/shellfish are principal food sources (Odland 2005;Boucher et al 2012;Laird et al 2013;Curren et al 2014).…”

Section: Environmental Toxins and Contaminantsmentioning

confidence: 99%

“…Concentrations of methylmercury and POPs in breast milk and cord blood of indigenous women in Arctic areas are 2-to 10-fold higher than those of populations in temperate latitudes (UNEP 2002;Imbeault et al 2012;Curren et al 2014). Studies of contaminant levels in blood found 50-500% higher levels of contaminants (heavy metals, pesticides, PCBs) in blood samples from indigenous communities in maritime/coastal areas than those of continental interior regions (Rubin et al 2001;AMAP 2003;Curren et al 2014).…”

Section: Environmental Toxins and Contaminantsmentioning

confidence: 99%

“…Studies of contaminant levels in blood found 50-500% higher levels of contaminants (heavy metals, pesticides, PCBs) in blood samples from indigenous communities in maritime/coastal areas than those of continental interior regions (Rubin et al 2001;AMAP 2003;Curren et al 2014). Among Inuits from the Nunavik region of northern Canada sampled during the period between 1992 and 1996, blood mercury levels from adult men and women averaged 15.4 lg/L (0.8-112.0 lg/L), while average total PCB levels from umbilical cord blood were 323.5 lg/ kg (Dallaire et al 2006;Valera et al 2012).…”

Section: Environmental Toxins and Contaminantsmentioning

confidence: 99%

“…than those of inland Dene/Metis women in Inuvik (0.61 lg/L) and eight times higher than those of Canadianborn women in southern Canada (0.4 lg/L) (Curren et al 2015). While concentrations of PCBs and certain other POPs chemicals appear to be declining in some areas (Fontaine et al 2008;Quinn et al 2012), recent studies have detected a suite of previously unreported new-generation POPs in Arctic biotas, some of which exhibit rapidly increasing concentrations (Braune et al 2005;Curren et al 2014).…”

Section: Environmental Toxins and Contaminantsmentioning

confidence: 99%

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Climate Change in the North American Arctic: A One Health Perspective

et al. 2015

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Climate change is expected to increase the prevalence of acute and chronic diseases among human and animal populations within the Arctic and subarctic latitudes of North America. Warmer temperatures are expected to increase disease risks from food-borne pathogens, water-borne diseases, and vector-borne zoonoses in human and animal populations of Arctic landscapes. Existing high levels of mercury and persistent organic pollutant chemicals circulating within terrestrial and aquatic ecosystems in Arctic latitudes are a major concern for the reproductive health of humans and other mammals, and climate warming will accelerate the mobilization and biological amplification of toxic environmental contaminants. The adverse health impacts of Arctic warming will be especially important for wildlife populations and indigenous peoples dependent upon subsistence food resources from wild plants and animals. Additional research is needed to identify and monitor changes in the prevalence of zoonotic pathogens in humans, domestic dogs, and wildlife species of critical subsistence, cultural, and economic importance to Arctic peoples. The long-term effects of climate warming in the Arctic cannot be adequately predicted or mitigated without a comprehensive understanding of the interactive and synergistic effects between environmental contaminants and pathogens in the health of wildlife and human communities in Arctic ecosystems. The complexity and magnitude of the documented impacts of climate change on Arctic ecosystems, and the intimacy of connections between their human and wildlife communities, makes this region an appropriate area for development of One Health approaches to identify and mitigate the effects of climate warming at the community, ecosystem, and landscape scales.

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Section: Environmental Toxins and Contaminantsmentioning

confidence: 99%

Section: Environmental Toxins and Contaminantsmentioning

confidence: 99%

Section: Environmental Toxins and Contaminantsmentioning

confidence: 99%

Section: Environmental Toxins and Contaminantsmentioning

confidence: 99%

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Climate Change in the North American Arctic: A One Health Perspective

et al. 2015

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“…For example, the risk associated with exposure to synthetically derived and concentrated chemicals is often perceived of as presenting major public health risks even in the absence of clear demonstration of effect. A tremendous and growing literature documents that people in remote corners of the world share a problem with populations in urban, agricultural, and industrial centers-bloodstreams that contain synthetically derived persistent organic pollutants (POPs) and a host of other contaminants resulting from modern industrial and agricultural processes (Gennings et al 2012;Haines and Murry 2012;Surren et al 2014). In the USA, the Centers for Disease Control and Prevention (CDC) periodically reports biomonitoring data related to environmental sources (U.S. Department of Health and Human Services 2015), providing a very useful tool in evaluating national exposure trends.…”

Section: Introductionmentioning

confidence: 99%

Preparation of environmental studies and sciences students to participate in the environmental risk dialogue

Silverman

Wally

2015

J Environ Stud Sci

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Environmental exposure to chemicals associated with modern industrial and agricultural practices is a major societal concern. Evaluating and managing risk from these chemicals requires knowledge based on both the natural and the social sciences. In this study, we investigated if students studying in environmental programs are acquiring the technical expertise, or focused preparation in risk sciences, to actively participate in risk assessment. Among programs with faculty associated with the Association of Environmental Studies and Sciences, we found that comprehensive preparatory coursework directed toward risk assessment was not a common feature among most programs. Preparation in statistics was evident among all degree programs, and those programs awarding Bachelor of Science degrees generally required foundational coursework in the natural sciences. Required coursework was rarely directly related to the risk sciences or toxicology. As a group, program graduates would not have acquired through their environmental program foundations central to the risk assessment processes. However, as shown in the analysis presented here, sufficient variation exists both among and within programs to anticipate that many individual graduates could have this preparation and make active contributions.

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Influence of pesticide physicochemical properties on the association between plasma and hair concentration

et al. 2016

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Although the relationship between chemical intake and resulting concentration in hair remains incompletely elucidated, the transfer from blood to hair bulb living cells is generally considered the main route of incorporation. The present work investigated the correlation between blood and hair concentration of 23 pesticides/metabolites from different chemical classes in rats submitted to chronic controlled exposure. Long-Evans rats were administered pesticides by gavage three times per week over a 90-day period. After hair sample decontamination, pulverization, and extraction, compounds were analyzed by gas chromatography tandem mass spectrometry (GC-MS/MS). Blood was collected at sacrifice, immediately turned into plasma, and analyzed after extraction for the same compounds by GC-MS/MS. The data obtained for all the investigated compounds demonstrated significant association between plasma and hair concentrations (P value of 2.97E-45 and R(Pearson) of 0.875), with the exception of three outliers. For all the target compounds, water solubility, lipophilicity, molecular weight, and charge were therefore investigated in order to understand the role of these parameters in outliers' specific behavior. Although a possible change in the charge through the transfer from blood to hair might be suspected for two outliers, on the whole the physicochemical parameters investigated here did not seem to influence incorporation of chemicals into hair. Our results support that the concentration of chemicals in hair mainly depends on the respective concentration in plasma and suggest that for most compounds, the transfer from blood to hair would not represent a limiting step in the incorporation.

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Comparing plasma concentrations of persistent organic pollutants and metals in primiparous women from northern and southern Canada

Cited by 27 publications

References 42 publications

Climate Change in the North American Arctic: A One Health Perspective

Climate Change in the North American Arctic: A One Health Perspective

Preparation of environmental studies and sciences students to participate in the environmental risk dialogue

Influence of pesticide physicochemical properties on the association between plasma and hair concentration

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