2018
DOI: 10.3390/antiox7060074
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Abstract: Background: Tocotrienol and tocopherol are known to prevent numerous degenerative diseases. The aim of this study is to compare the effects of tocotrienol-rich fraction (TRF) with α-tocopherol (α-TF) on the antioxidant status of healthy individuals aged between 50 and 55 years. Methods: Volunteers were divided into groups receiving placebo (n = 23), α-TF (n = 24) and TRF (n = 24). Fasting venous blood samples were taken at baseline (0 month), 3 months and 6 months of supplementation for the determination of su… Show more

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Cited by 26 publications
(24 citation statements)
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“…Furthermore, vitamin E interacts with other cellular components and may help foster the antioxidative environment [6,8]. Superoxide dismutase (SOD), a crucial antioxidative enzyme in the body, can partition superoxide radicals into oxygen or hydrogen peroxide and is increased with vitamin E supplementation [6,10,11,12,13]. Vitamin E also increases the actions of other antioxidative enzymes such as catalase and glutathione peroxidase [6,11,12,13].…”
Section: Mechanism Of Action and Therapeutic Role Of Vitamin E In mentioning
confidence: 99%
See 1 more Smart Citation
“…Furthermore, vitamin E interacts with other cellular components and may help foster the antioxidative environment [6,8]. Superoxide dismutase (SOD), a crucial antioxidative enzyme in the body, can partition superoxide radicals into oxygen or hydrogen peroxide and is increased with vitamin E supplementation [6,10,11,12,13]. Vitamin E also increases the actions of other antioxidative enzymes such as catalase and glutathione peroxidase [6,11,12,13].…”
Section: Mechanism Of Action and Therapeutic Role Of Vitamin E In mentioning
confidence: 99%
“…Superoxide dismutase (SOD), a crucial antioxidative enzyme in the body, can partition superoxide radicals into oxygen or hydrogen peroxide and is increased with vitamin E supplementation [6,10,11,12,13]. Vitamin E also increases the actions of other antioxidative enzymes such as catalase and glutathione peroxidase [6,11,12,13]. Through gene expression modulation, dietary vitamin E can decrease c-myc and transform growth factor-alpha expression, leading to decreased nitric oxide synthase (iNOS) and the reduced form of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase which are major contributors to oxidative stress [13,14].…”
Section: Mechanism Of Action and Therapeutic Role Of Vitamin E In mentioning
confidence: 99%
“…In the current study, increased RLT and retinal cell count with a reduction in retinal cell apoptosis among oral TRF-treated diabetic rats might be attributed to its ability to reduce blood sugar level as well as antioxidant properties. TRF is a potent antioxidant [44], and, additionally, it has been shown to have a direct anti-apoptotic effect against neuronal cells' apoptosis due to glutamate excitotoxicity [45]. Since excitotoxicity is known to be involved in diabetes-induced retinal neuron loss [46], this direct anti-apoptotic activity of TRF may also underlie its protective effect against changes in retinal morphology in diabetic rats.…”
Section: Discussionmentioning
confidence: 99%
“…TRF supplementation for 150 mg/day in older adults for six months markedly increased the SOD activity to 0.130 from 0.118 U/mL at baseline. There was also a significant increase in GPX activity in female subjects compared to baseline (2250 vs. 1750 nmol/mL/ min, respectively; p < 0.05) and 2.5-fold elevation of GSH/GSSG ratio after TRF supplementation ( Table 3 ) [ 188 ]. It could enhance the GSH pool via several mechanisms.…”
Section: Dysregulation Of Antioxidant and Pro-oxidant Enzymesmentioning
confidence: 99%