Comparing HbA1c, fasting and 2-h plasma glucose for screening for abnormal glucose regulation in patients undergoing coronary angiography

Abstract

Using HbA1c and OGTT to screen, we reported an extremely high prevalence of previously undiagnosed AGR (28.0% diabetes and 60.4% prediabetes) in patients admitted for CAG. HbA1c may be adopted as an alternative to OGTT for screening for AGR in patients undergoing CAG.

New trends in the long and puzzling history of HbA1c

“…Wang et al suggest that HbA 1c could constitute an interesting alternative solution in patients undergoing coronary angiography [9], reinforcing conclusions drawn from previous studies showing the interest of HbA 1c assay for this indication in other cardiovascular diseases, such as acute ischemic stroke [10].…”

Negative association between serum aryl hydrocarbon receptor concentrations and β‐cell function in patients with no history of diabetes undergoing coronary angiography

“…All patients underwent an OGTT 2–4 weeks after they had been discharged from hospital, when their heart disease was stable. After an overnight fast, patients were interviewed by a trained nurse at at the outpatient clinic of Taichung Veterans General Hospital using methods reported previously . Patients’ height, weight, waist circumference, and blood pressure were measured.…”

“…After an overnight fast, patients were interviewed by a trained nurse at at the outpatient clinic of Taichung Veterans General Hospital using methods reported previously. 19,20 Patients' height, weight, waist circumference, and blood pressure were measured. A fasting blood sample was obtained for measurement of plasma glucose, insulin, AhR, and lipid profiles.…”

“…Although AhR has been associated with an increased risk of T2DM, there is little information regarding the association of AhR with β‐cell function. Previous studies have reported that AhR is associated with atherosclerosis and coronary artery disease (CAD), and there is a high prevalence of undiagnosed abnormal glucose regulation in patients with CAD . To investigate whether there is an association between serum AhR concentrations and insulin resistance or β‐cell function and, if so, whether the association is independent of other risk factors for abnormal glucose regulation (e.g.…”

“…Previous studies have reported that AhR is associated with atherosclerosis and coronary artery disease (CAD), 15,16 and there is a high prevalence of undiagnosed abnormal glucose regulation in patients with CAD. [17][18][19][20] To investigate whether there is an association between serum AhR concentrations and insulin resistance or β-cell function and, if so, whether the association is independent of other risk factors for abnormal glucose regulation (e.g. hypertension and CAD), the present study was performed in subjects with no history of diabetes who had been admitted for coronary angiography due to suspected or known CAD.…”